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  • 1
    Electronic Resource
    Electronic Resource
    Neurotoxicity of antitumoral IL-2 therapy: Evoked cognitive potentials and brain mapping (1994)
    Springer
    Neurological sciences 15 (1994), S. 341-346 
    Details
    ISSN: 1590-3478
    Keywords: interleukin-2 ; neurotoxicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario La terapia antitumorale con interleuchina-2 (IL-2) è frequentemente associata a neurotossicità che si manifesta con disturbi neuropsichiatrici e, più raramente, con segni neurologici focali. Allo scopo di documentare l'interessamento delle funzioni cognitive dopo terapia con IL-2 abbiamo studiato 20 pazienti con potenziali evocati cognitivi (P300) e analisi computerizzata del segnale EEG. Nel confronto tra gli esami effettuati prima e dopo infusione sottocutanea di IL-2 abbiamo osservato un significativo allungamento della latenza media della P300 e un aumento percentuale delle frequenze EEG contenute nelle bande delta e teta, specie sulle regioni frontali.
    Notes: Abstract Antitumoral interleukin-2 (IL-2) therapy is frequently associated with a neurotoxicity that manifests itself in neuropsychiatric disturbances and, more rarely, with neurological focal signs. With the aim of documenting the involvement of cognitive functions after IL-2 treatment, we studied 20 patients using evoked cognitive potentials (P300) and computer analysis of the EEG signal. A comparison of the tests performed before and after the subcutaneous infusion of IL-2 showed a significant lengthening in mean P300 latencies and a percentage increase in the EEG frequencies contained with the delta and theta bands, especially in the frontal regions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02339930
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  • 2
    Electronic Resource
    Electronic Resource
    Paclitaxel neurotoxicity: clinical and neurophysiological study of 23 patients (1997)
    Springer
    Neurological sciences 18 (1997), S. 73-79 
    Details
    ISSN: 1590-3478
    Keywords: Paclitaxel ; Neurotoxicity ; Distal axonopathy ; Platinum-compounds
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Il Paclitaxel appartiene a una nuova categoria di farmaci antiblastici la cui attività è legata alla capacità di interferire con il sistema dei microtubuli. La neurotossicità periferica è dovuta all'interferenza con i microtubuli assonali e all'alterazione del trasporto assonale. Allo scopo di definire le caratteristiche cliniche e neurofisiologiche di questa neuropatia sono stati studiati 23 pazienti sottoposti a terapia con Paclitaxel al dosaggio di 175 mg/mq. I risultati dello studio hanno mostrato un'elevata incidenza di neurotossicità periferica di grado moderato, valutata con una scala di neurotossicità basata sui segni e sintomi clinici e sui dati neurofisiologici. L'insieme dei dati permette di definire la neuropatia da Paclitaxel come una neuropatia sensitivo-motoria distale di tipo assonale, la cui reversibilità richiede ulteriori conferme.
    Notes: Abstract Paclitaxel is the prototype of a new class of chemotherapeutic agents with an antimitotic effect that is related to its ability to interfere with the microtubule system. It causes peripheral neurological toxicity by means of its activity on the axonal microtubules. To define the clinical and neurophysiological characteristics of paclitaxel neuropathy 23 patients undergoing paclitaxel therapy at a dose of 175 mg/m2 were studied. The patients were divided into two groups, with only one group receiving pretreatment with potentially neurotoxic drugs such as cisplatin and carboplatin. The results showed a high incidence of mild neurotoxicity in both groups. Treatment was discontinued due to severe neurotoxicity in only one patient pretreated with platinum-compounds. The clinical and neurophysiological data make it possible to define paclitaxel neurotoxicity as a distal axonal neuropathy with a summatory effect in patients pretreated with cisplatin; the possible reversibility of paclitaxel neurotoxicity requires further confirmation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01999566
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  • 3
    Electronic Resource
    Electronic Resource
    Brachial plexus neuropathy as unusual onset of diffuse neurolymphomatosis (2000)
    Springer
    Neurological sciences 21 (2000), S. 241-245 
    Details
    ISSN: 1590-3478
    Keywords: Key words Non-Hodgkin's lymphoma ; Neurolymphomatosis ; Paraneoplastic neuropathy ; Guillain-Barré syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We present a patient with a large B cell gastric lymphoma in total remission who, after 4 months, developed a fatal progressive peripheral neuropathy with an unusual early involvement of the right brachial plexus. No evidence of lymphoma was found at whole body computed tomography, magnetic resonance imaging of the head, cervical spine and right brachial plexus, bone marrow biopsy or repeated lumbar punctures. The diagnosis of neurolymphomatosis was made only at postmortem examination.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100720070083
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  • 4
    Electronic Resource
    Electronic Resource
    Diabetic neuropathy of the lateral cutaneous nerve of the calf. A case report (1985)
    Springer
    Neurological sciences 6 (1985), S. 107-108 
    Details
    ISSN: 1590-3478
    Keywords: Diabetic mononeuritis ; lateral cutaneous nerve of the calf
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Viene riportato un caso di mononeurite del cutaneo laterale della gamba insorta in una paziente affetta da diabete mellito inadeguatamente controllato. Completo e rapido controllo della sintomatologia dolorosa con carbamazepina.
    Notes: Abstract We report a case of neuropathy of the lateral cutaneous nerve of the calf in a patient with inadequately controlled diabetes mellitus. The painful syndrome was controlled with carbamazepine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02229228
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  • 5
    Electronic Resource
    Electronic Resource
    Anterior interosseous nerve syndrome (1988)
    Springer
    Neurological sciences 9 (1988), S. 41-45 
    Details
    ISSN: 1590-3478
    Keywords: Anterior interosseous nerve ; median nerve ; Kiloh-Nevin syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario La paralisi dei muscoli flessore lungo del pollice, flessore profondo delle dita e pronatore quadrato è generalmente attribuita a lesionidel nervo interosseo anteriore all’avambraccio. La stessa sindrome può essere determinata da lesioni del mediano a livello del gomito e da lesioni delle fibre destinate all’interosseo anteriore a livello delle corde del plesso brachiale. Gli Autori presentano 4 casi di sindrome dell’interosseo anteriore, tre dei quali spontanei e uno traumatico. Essi passano in rassegna i fattori etiopatogenetici, il quadro clinico ed i reperti elettromiografici relativi alla sindrome.
    Notes: Abstract Weakness of the flexor pollicis longus, flexor digitorum profundus and pronator quadratus is usually related to an isolated paralysis of the anterior interosseous nerve in the volar aspect of the forearm. The same syndrome may be caused by lesions of the median nerve in the supracondylar region and by involvement of the fibers assigned to the abovementioned nerve in the medial and lateral cords of the brachial plexus. We report 4 cases of the anterior interosseous nerve syndrome (3 spontaneous and one traumatic), review and discuss etiological factors, clinical features and electromyographic findings in the syndrome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02334406
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