ISSN:
1432-1459
Keywords:
Blood-CSF barrier
;
CSF proteins
;
Acute lymphoblastic leukaemia
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Ten children affected by acute lymphoblastic leukaemia without CNS involvement were treated with a CNS prophylaxis protocol. Intrathecal methotrexate and CNS irradiation (60Co) administered at different times both induced an increase in blood-CSF barrier permeability to serum proteins (albumin, IgG, alpha2 macroglobulin). The relationship between permeability coefficients of proteins was analysed by theoretical porous or vesicular blood-CSF barrier models. The analysis indicated that both therapeutic procedures affect endothelial pinocytosis. An increase in radius of pinocytotic vesicles from 400 to 1500 Å seemed the most relevant change. The damage of endothelial barrier permselectivity could be involved in acute and late delayed toxic effects of intrathecal methotrexate and of CNS irradiation.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00313712
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