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  • 1
    Electronic Resource
    Electronic Resource
    143
The Effect of Various Antimicrobial Agents on Acinetobacter Baumannii: An In Vitro Evaluation (2005)
    Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.
    Wound repair and regeneration 13 (2005), S. 0 
    Details
    ISSN: 1524-475X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background:  Acinetobacter baumannii has recently emerged as an important hospital-acquired pathogen, especially in surgery, burn, and intensive care units. Due to its ability to develop resistance to antimicrobials, wound infection with A. baumannii is difficult to treat, and can lead to septicemia and even death. Use of appropriate topical antimicrobial agents in these circumstances could be one of the first steps in prevention of A. baumannii wound infection.Objectives:  In this study, we will discuss the in vitro effects of seven common topical antimicrobial creams and dressings on A. baumannii.Methods:  A. Baumannii ATCC# 6919 was subjected to sensitivity tests against mupirocin, silver sulfadiazine, mafenide acetate, a double antibiotic combination of polymyxin and bacitracin, a triple antibiotic combination of Neomycin, bacitracin and polymyxin, and two silver-containing dressings. Zones of inhibition were measured after 24 hours incubation period.Results and Conclusion:  Of the evaluated antimicrobial agents, mafenide acetate was the most efficacious followed by mupirocin, triple and double antibiotic combinations in decreasing order. The silver-containing dressings yielded a lesser zone of inhibition as compared to the previously mentioned, and no zone of inhibition was observed using silver sulfadiazine. Further in vivo studies on the effect of antimicrobial agents against A. Baumannii are necessary to substantiate these findings and determine the potential clinical relevance of these therapies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1067-1927.2005.130216au.x
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  • 2
    Electronic Resource
    Electronic Resource
    132
Can a Topical Antimicrobial Agent Penetrate a Bi-Layered Cell Therapy and be Effective Against Methicillin-Resistant Staphylococcus Aureus? (2005)
    Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.
    Wound repair and regeneration 13 (2005), S. 0 
    Details
    ISSN: 1524-475X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background:  Bilayered cell therapy (BLCT) is a significant advancement in the field of wound healing. BLCT expresses multiple growth factors found in normal skin, and provides a biologically active matrix in chronic wounds. Antibiotic-resistant bacterium continues to be a major problem in chronic wounds. The use of appropriate topical antimicrobial agents could be one of the first steps in prevention of wound infection, although their use with BLCT is limited due to reported toxicity to cultured keratinocytes.Objectives:  This study was designed to see whether a topical antimicrobial agent is able to permeate through the BLCT and inhibits the growth of Methicillin-Resistant Staphylococcus Aureus (MRSA). Mupirocin was used because of its lack of toxicity to cultured keratinocytes.Methods:  MRSA (ATCC# 33591) strain was used for these studies. The entire surface of blood agar plates were covered with a high inoclum of MRSA. BLCT specimens were placed on the agar plates and mupirocin was then applied on the top surface. As a positive control, mupirocin was applied directly on the agar plate, while BLCT specimens alone were used as negative control. The plates were subsequently incubated for 24 hours after which the zones of inhibition were assessed.Results:  Placing mupirocin on top of BLCT gave a 41.9 ± 17.2 mm inhibition zone diameter. Although it was smaller than the inhibition zone diameter produced by direct administration of mupirocin (26.3 ± 9.4 mm), this difference was not statistically significant. BLCT by itself did not create a zone of inhibition.Conclusion:  Mupirocin is able to permeate BLCT and inhibit the bacterial growth underneath it. This study may have important clinical implications.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1067-1927.2005.130216aj.x
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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