ISSN:
1434-1948
Keywords:
Bioinorganic chemistry
;
Copper
;
DNA cleavage
;
Intercalation
;
Chemistry
;
General Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The synthesis of three novel derivatives [N-acetyl-Clip-Phen (1), Clip-Phen-hexylaminoacridine (4) and Clip-Phen-hexylchloromethoxyaminoacridine (5)] of the bis(phenanthroline) ligand “Clip-Phen”, are described. Complexation of these ligands with copper(II) afforded the 1:1 complexes as hexafluorophosphate salts. The relaxation of φX 174 DNA was used as a DNA cleavage assay, with the following results. [Cu(1)]2+ was found to show a diminished activity relative to the parent complex [Cu(Clip-Phen)]2+. However, the acridine-containing complexes [Cu(4)H]3+ and [Cu(5)H]3+ exhibited significantly enhanced cleavage efficiencies, which has been attributed to increased affinity of the complexes for DNA. UV/Vis-spectral data of the complexes in the presence of calf-thymus DNA was consistent with an intercalative mode of binding.
Additional Material:
4 Ill.
Type of Medium:
Electronic Resource
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