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  • 1
    Electronic Resource
    Electronic Resource
    The altered expression of MHC-class II determinants on monocytes of cancer patients (1988)
    Springer
    Cancer immunology immunotherapy 27 (1988), S. 171-176 
    Details
    ISSN: 1432-0851
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The expression of MHC class II determinants Ia.7 (detected by cross reactive mouse anti-Iak antibody) and HLA-DR on monocytes (MO) of gastric and colorectal cancer patients was examined. An increased proportion of MO bearing the Ia.7 determinant was found, while the number of MO expressing DR was not elevated. In gastric cancer patients the increased expression of the Ia.7 determinant was most pronounced in advanced cancer (stage IVA and IVB). The increased expression of this determinant was related to the presence of the tumour as the number of MO expressing Ia.7 decreased 6 months following surgical resection of the tumour. Further, the increased expression of Ia.7 on MO correlated with the tumour infiltration of the serosa. The Ia.7 determinants were mainly expressed on MO which also expressed the receptor for the Fc part of immunoglobulin. Immunostaining in cellular infiltrates surrounding the tumour revealed that Ia.7+ macrophages (MØ) were more numerous than in normal gastric mucosa and severe chronic gastritis and were mostly present in close proximity to tumour cells, while DR+ MØ were mainly localized within the stromal tissue of the tumour and their number was not increased in cancer infiltrates. These observations indicate that the Ia.7+ subpopulation of MØ may be involved in the anti-tumour response of the host.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00200023
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  • 2
    Electronic Resource
    Electronic Resource
    “Activated” monocytes in gastric cancer patients (1982)
    Springer
    Journal of cancer research and clinical oncology 104 (1982), S. 181-190 
    Details
    ISSN: 1432-1335
    Keywords: Gastric cancer ; Monocytes ; Fc receptor ; ADCC ; NBT reduction ; “Activation”
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The Fc receptor expression, antibody-dependent cellular cytotoxicity (ADCC), and nitro-blue tetrazolium (NBT) reduction of peripheral blood monocytes from 150 patients with different stages of gastric cancer was assessed and compared with results obtained in 77 normal persons and 104 patients with non-malignant diseases of the gut. Monocytes of cancer patients showed an increased ability to form rosettes with human 0, Rh+ erythrocytes coated with D-specific antibody. ADCC and NBT reduction were also elevated but no correlation was found with the stage of disease. However, all these phenomena were related to the tumor load as elevated values were the same 4–6 months after surgery in the unresectable-tumor group, while they decreased in patients with resectable tumors. These observations suggest that monocytes of some cancer patients are functionally altered (“activated”) in the course of disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00402066
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Serial immunological testing in patients with gastric cancer (1986)
    Springer
    Journal of cancer research and clinical oncology 111 (1986), S. 62-70 
    Details
    ISSN: 1432-1335
    Keywords: Gastric cancer ; Cellular immunity ; T lymphocytes ; Monocytes ; Follow up
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Standard immunological parameters measuring non-specific cellular immune reactivity were determined in 175 patients with different stages of gastric cancer prior to surgery and during follow-up. Several tests measuring monocyte activity were also employed. The total number of T cells and their subpopulations Ta and T29° was unchanged except depression of T29° in stage IV. The blastogenic response of lymphocytes to PHA as assessed by stimulation of protein synthesis was only depressed in stage IV. In contrast the PHA-induced lymphokine production was increased in all patients but the differences were significant for stage III and IV. Monocyte Fc receptor expression was increased in stages II-IV, while nitro blue tetrazolium reduction and antibody dependent cellular cytotoxicity of monocytes was elevated in stage IV. The number of extractable monocytes was not increased. Longitudinal studies suggested that most of the parameters normalized during follow-up. No major long-term impact of chemoimmunotherapy (5-FU+BCG) on the immune parameters was observed except a transient increase in PPD reactivity approximately 1 year after commencement of treatment. In patients with stage III gastric cancer the increased occurrence of suppressor cells (mostly monocytes) and elevated cytostatic activity of monocytes was associated with a longer survival while the increased lymphokine production and Fc receptor expression were seen in the group of patients succumbing earlier. We concluded that most of the changes in immune parameters were seen only in advanced disease and paradoxically disappeared in the course of disease. The determination of monocyte activity seems to be a sensitive indicator of immune system dearrangements in earlier stages of cancer and a useful prognostic factor in gastric cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00402779
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Serial immunological testing in patients with Gastric Cancer (1986)
    Springer
    Journal of cancer research and clinical oncology 111 (1986), S. 295-295 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00389249
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Isotype-specific regulation of MHC class II gene expression in human monocytes by exogenous and endogenous tumor necrosis factor (1995)
    Springer
    Journal of clinical immunology 15 (1995), S. 185-193 
    Details
    ISSN: 1573-2592
    Keywords: Human monocytes ; TNF ; MHC class II ; TNF-receptors ; thalidomide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The control of expression of MHC class II molecules on antigen-presenting cells is important for the induction of immunity, while aberrant expression of these molecules plays a role in the immunopathology of autoimmune diseases. This study explored the role of tumor necrosis factor alpha (TNF) in controlling the level of HLA class II mRNA in human monocytes. Exposure of monocytes to exogenous recombinant TNF (rTNF) selectively up-regulated DRα-mRNA but not DP or DQα-mRNA. Inhibitors of TNF synthesis, pentoxifylline (PTX) and thalidomide, inhibited TNF mRNA accumulation in LPS-activated monocytes and down-regulated DR mRNA but not DP or DQ mRNA. The inhibitory effect of anti-TNF monoclonal antibody (MAb) indicated that endogenously generated TNF acted extracellularly. Anti-p75 TNF-R2 receptor and to a lesser extent anti-p55 TNF-R1 MAbs inhibited TNF-mediated up-regulation of DR mRNA and TNF mRNA. Taken together, this implies that endogenously generated TNF plays a role in controlling isotype-specific MHC class II gene expression in human monocytes/macrophages. These results may have some implications for anti-tumor response and autoimmunity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01541088
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    Paper (German National Licenses)
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