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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 5 (1901), S. 149-150 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 5 (1901), S. 149-149 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Aicardi-Goutières syndrome (AGS) presents as a severe neurological brain disease and is a genetic mimic of the sequelae of transplacentally acquired viral infection. Evidence exists for a perturbation of innate immunity as a primary pathogenic event in the disease phenotype. Here, we show ...
    Type of Medium: Electronic Resource
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  • 4
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    Cambridge, Mass. : Periodicals Archive Online (PAO)
    Ploughshares. 15:4 (1989/1990:Winter) 166 
    ISSN: 0048-4474
    Topics: Linguistics and Literary Studies , English, American Studies
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  • 5
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    Cambridge, Mass. : Periodicals Archive Online (PAO)
    Ploughshares. 15:4 (1989/1990:Winter) 167 
    ISSN: 0048-4474
    Topics: Linguistics and Literary Studies , English, American Studies
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  • 6
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Neuropsychologia 31 (1993), S. 1321-1337 
    ISSN: 0028-3932
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Psychology
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-1998
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report the results of a 14-year retrospective study of brain MRI abnormalities in 12 pediatric patients presenting with hypomelanosis of Ito (HI). Miscellaneous brain abnormalities were found: one patient had a medulloblastoma, three had cortical malformations, and five demonstrated “minor” abnormalities such as dilated Virchow-Robin spaces or brain atrophy. We emphasize the polymorphism of brain abnormalities associated with HI.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1437-3262
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Description / Table of Contents: Abstract Marine sediment location spread over a wide range of environments contain evidence of anoxic intervals dated early Late Cretaceous. In the north and south deep Atlantic deposition of anoxic layers followed a widespread sedimentary hiatus of Middle Cenomanian age. In the eastern-central parts of the Atlantic (Angola and Cape Verde basins) rythmic deposition of anoxic layers commenced in the Latermost Cenomanian and lasted as late as the Santonian. In the rest of the deep north Atlantic on the contrary anoxia duration was probably limited to the Cenomanian-Turonian boundary or thereabout. Late Cretaceous anoxic layer is not yet recorded south of the Walvis-Rio Grande Rises in the South Atlantic. In a number of locations in marginal and epicontinental seas in America, Africa and Europe previously related to the Tethys a few anoxic layers dated Cenomanian-Turonian are intercalated within thick oxic series. Coniacian to Santonian anoxic layers are limited to small areas in epeiric and marginal domains in the southern Alps, North Africa, Israel, North America (Santonian in the Western Interior) and (?) Australia all with no clear link with any ocean-wide event of early Senonian age. Rythmical alternation of oxic/anoxic layers helps to document the emplacement of sediment and disposition of anaerobic water masses. Development of anoxia at about the Cenomanian-Turonian boundary induced abnormal concentration of trace metals and a partial renewal of the marine fauna. To understand the relationship between a number of factors such as sea-level changes, climates, terrestrial influences, biogenic fertility, sedimentation rates, etc., is essential to explain of the very peculiar anoxic global event of early Late Cretaceous age.
    Abstract: Résumé Le Crétacé supérieur a été une période favorable au développement de milieux anoxiques depuis les régions profondes de l'Atlantique et de la Tethys occidentale jusqu'aux mers épicontinentales adjacentes. Après une lacune sédimentaire datée du Cénomanien moyen et générale dans l'Atlantique, l'anaérobiose a duré de manière épisodique depuis le Cénomanien terminal jusqu'au Santonien dans la partie orientale de l'océan (bassins du Cap Vert et de l'Angola). Ailleurs, elle a été restreinte dans le temps aux alentours de la limite Cénomanien-Turonien, sauf au Sud de la ride Rio-Grande Walvis où elle n'a pas été reconnue encore par forage. Plusieurs couches de sédiments anoxiques présentes dans des séries plus ou moins épaisses, déposées en milieu aérobie sont connues également à la limite Cénomanien-Turonien, dans les mers épicontinentales fossiles d'Amérique, d'Afrique et d'Europe. Il semble donc que l'événement anoxique commençant à l'extrême fin du Cénomanien ait un caractère global. Des dépôts anoxiques d'âge Sénonien inférieur ont été repérés aussi sur des surfaces limitées dans les Alpes méridionales, en Afrique du Nord, en Amérique du Nord (Santonien du Western Interior Basin), en Israel et peut-être en Australie. L'êtude des alternances de couches aérobies et anaérobies de différents types permet la reconstitution de la disposition des masses d'eau anoxiques au moment du dépôt. L'événement anoxique du Cénomanien-Turonien a déterminé diverses anomalies géochimiques dans les sédiments ainsi qu'un renouvellement d'une partie de la faune benthique et planctonique. La compréhension des relations mutuelles complexes entre les différents facteurs qui régissent les caractéristiques des milieux océaniques est essentielle pour interpréter un événement aussi singulier que l'anoxie globale datée des alentours de la limite Cénomanien-Turonien.
    Notes: Zusammenfassung Während der oberen Kreide entstanden bevorzugt anoxische Bedingungen, sowohl in den tiefen Gebieten des Atlantiks und der westlichen Tethys, als auch in den naheliegenden epikontinentalen Meeren. Nach der im ganzen Atlantik vorkommenden sedimentären Lücke des mittleren Cenomans, dauerte die Anaerobiose, mit mehreren Unterbrechungen, vom obersten Cenoman bis zum Santon, jedenfalls im östlichen Teil des Ozeans (Cape-Verde und Angola Becken). Andernorts war sie zeitlich auf den Grenzbereich zwischen Cenoman und Turon beschränkt, außer im Süden des Rio Grande-Walvis Rückens, wo sie durch Bohrungen noch nicht festgestellt wurde. In den epikontinentalen Teilen des Paläo-ozeans Amerikas, Afrikas u. Europas kennt man auch mehrere anoxische Sedimentlagen, die in mächtige oxische Ablagerungen eingebettet sind. Also scheint das im obersten Cenoman beginnende anoxische Ereignis eine globale Bedeutung zu besitzen. Kleinere Flächen von anoxischen Ablagerungen des unteren Senons wurden auch in den südlichen Alpen, in Nordafrika, in Israel und vielleicht in Australien entdeckt. Sie stehen aber in keinem weltweiten Zusammenhang. Aus der Untersuchung der Wechsellagerung der oxischen und anoxischen Schichten läßt sich die Lage der oxischen Wassermassen zur Zeit der Ablagerung bestimmen. Das anoxische Cenoman-Turon Ereignis bewirkte verschiedene geochemische Unregelmäßigkeiten in den Sedimenten und hatte gleichfalls eine partielle Erneuerung der gesamten Fauna zur Folge. Um ein solch seltsames Ereignis, wie diese globale Anoxie um die Wende Cenoman-Turon zu verstehen, ist es nötig, das Zusammenwirken verschiedener Faktoren, wie Meeresspiegel- und Klimaschwankungen, kontinentale Einflüsse, organische Produktivität, Sedimentationsraten usw. zu erfassen.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 89 (1994), S. 72-84 
    ISSN: 1432-0533
    Keywords: Key words     Type II lissencephaly ; Polymicrogyria ; Development ; Meninges ; Neurocristopathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report neuropathological studies of five cases of type II lissencephaly from three fetuses and two infants. This comparative study allowed us to determine the developmental course of the cerebral lesions. Two distinct developmental events seem to generate this type of brain malformation: firstly, an early disturbance in cortex formation, which results both from a disorder of radial migration and a pial barrier disruption; secondly, a late perturbation of cerebral surface organization, resulting in fusion of the cerebral surface. All these features can be related to a primitive meningeal pathology, and more generally, to a neurocristopathy. Accordingly to our observations, this brain malformation appears during both migrational and post-migrational stages and may be considered more like a polymicrogyria than a lissencephaly.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-0533
    Keywords: Key words Leukodystrophy ; Oligodendrocyte ; Myelin ; Orthochromatic ; CACH syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report neuropathological, biochemical and molecular studies on two patients with childhood ataxia with diffuse central nervous system hypomyelination (CACH) syndrome, a leukodystrophy recently defined according to clinical and radiological criteria. Both had severe cavitating orthochromatic leukodystrophy without atrophy, predominating in hemispheric white matter, whereas U-fibers, internal capsule, corpus callosum, anterior commissure and cerebellar white matter were relatively spared. The severity of white matter lesions contrasted with the rarity of myelin breakdown products and astroglial and microglial reactions. In the white matter, there was an increase in a homogeneous cell population with the morphological features of oligodendrocytes, in many instances presenting an abundant cytoplasm like myelination glia. These cells were negative for glial fibrillary acidic protein and antibodies PGM1 and MIB1. Some were positive for myelin basic protein, proteolipid protein (PLP), and myelin oligodendrocyte glycoprotein, but the majority were positive for human 2′-3′ cyclic nucleotide 3′ phosphodiesterase and all were positive for carbonic anhydrase II, confirming that they are oligodendrocytes. Myelin protein and lipid content were reduced. The PLP gene, analyzed in one case, was not mutated or duplicated. The increased number of oligodendrocytes without mitotic activity suggests an intrinsic oligodendroglial defect or an abnormal interaction with axons or other glial cells. This neuropathological study supports the notion that CACH syndrome constitutes a specific entity.
    Type of Medium: Electronic Resource
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