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  • 1
    Electronic Resource
    Electronic Resource
    Herring Bodies Reexamined: An Ultrastructural Experimental Investigation of the Rat Neural Lobe1,2 (1974)
    Oxford, UK : Blackwell Publishing Ltd
    Anatomia, histologia, embryologia 3 (1974), S. 0 
    Details
    ISSN: 1439-0264
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1439-0264.1974.tb00376.x
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  • 2
    Electronic Resource
    Electronic Resource
    Modifications in the sarcoplasmic reticulum and subcellular calcium distribution in skeletal muscle in a case of Westphal's disease (hypokalemic periodic paralysis) (1979)
    Springer
    Virchows Archiv 383 (1979), S. 345-350 
    Details
    ISSN: 1432-2307
    Keywords: Hypokalemic periodic paralysis ; Calcium ; Sarcoplasmic reticulum ; T tubules
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a case of hypokalemic periodic paralysis with characteristic alterations of the sarcoplasmic reticulum (SR) in the skeletal muscle, subcellular calcium re-partition, as revealed with the pyroantimonate technique, appears disturbed during paralysis. Pyroantimonate precipitates, normally concentrated in the terminal cisternae of the SR, were localized in the T tubules, whereas the terminal cisternae appeared empty. The increase (about 14%) in muscular calcium during paralysis may result from the accumulation of calcium in the extracellular compartment (T tubules). Defects in calcium uptake and storage by the SR may be. involved in the pathogenesis of the periodic paralysis syndrome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00430251
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  • 3
    Electronic Resource
    Electronic Resource
    Storage of proteins in the rough endoplasmic reticulum of human hepatocytes in a patient with normal blood proteins, on oral contraceptives (1977)
    Springer
    Virchows Archiv 375 (1977), S. 241-248 
    Details
    ISSN: 1432-2307
    Keywords: Hepatocyte ; Rough endoplasmic reticulum ; Protein storage ; Oral contraceptives
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Aspects of protein storage in the rough endoplasmic reticulum of hepatocytes, comparable with those reported in α1-antitrypsine (AAT) deficiency, have been observed in the course of jaundice in a woman presenting no evident abnormality in AAT or other blood proteins. In light microscopy, most hepatocytes contained characteristic globular inclusions but they were PAS negative and did not react with anti-AAT antibodies. This storage of protein ceased at the time the jaundice disappeared. Prolonged treatment with high doses of contraceptive steroids may have been involved in this peculiar reaction of the hepatocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01102992
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  • 4
    Electronic Resource
    Electronic Resource
    Unusual familial cardiomyopathy with storage of intermediate filaments in the cardiac muscular cells (1980)
    Springer
    Virchows Archiv 386 (1980), S. 43-58 
    Details
    ISSN: 1432-2307
    Keywords: Cardiomyopathy ; Intermediate filaments ; Sarcoplasmic reticulum ; Glycogen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Unusual histological and ultrastructural changes in cardiac muscle cells have been found in 3 brothers with progressive myocardial deficiency. Histologically, this cardiomyopathy was characterized by massive storage of PAS-negative proteinaceous material in most cardiac muscle cells. The electron microscope showed that this material consisted of sinuous filaments, 7–10 nm in diameter, similar to the intermediate filaments normally present in cardiac muscle cells. Filament storage coincided with the disintegration of neighbouring myofibrils, with particular change in Z bands giving rise to rod-like bodies and more complex structures formed by the association of Z band material and sarcoplasmic reticulum (SR) tubules. Filament storage and myofibrillar disintegration always occurred in areas where the SR developed and involuted extensively. Relatively high glycogen accumulation also occurred, in close relation to the SR changes. Discrete SR proliferation, glycogen overload and filament deposits were observed in a few skeletal fibres. These observations suggest that disturbance in the metabolism of desmin (protein subunit of intermediate filaments and a fundamental component of Z bands) might be involved in this type of cardiomyopathy. The influence of a chronic defect in calcium regulation might also be envisaged in view of the marked SR abnormalities.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00432643
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  • 5
    Electronic Resource
    Electronic Resource
    An unusual familial cardiomyopathy characterized by aberrant accumulations of desmin-type intermediate filaments (1981)
    Springer
    Virchows Archiv 393 (1981), S. 53-60 
    Details
    ISSN: 1432-2307
    Keywords: Cardiomyopathy ; Intermediate filaments ; Immunofluorescence ; Desmin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Immunofluorescence microscopy using antibodies specific for different intermediate filament types has been used to study a rare familial cardiomyopathy characterized electron microscopically by massive accumulations of unordered intermediate filaments. The results show that the inclusions in cardiac muscle cells are composed of the desmin type of intermediate filament characteristic of muscle tissues, and draw attention to the importance of these filaments in maintaining normal cardiac ultrastructure and function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00430870
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  • 6
    Electronic Resource
    Electronic Resource
    Togavirus-like particles in renal epithelium of patients with systemic lupus erythematosus (1978)
    Springer
    Virchows Archiv 380 (1978), S. 119-122 
    Details
    ISSN: 1432-2307
    Keywords: Systemic lupus erythematosus ; Renal epithelium ; Togavirus-like particles
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Virus-like particles, about 45 nm in diameter, were present in renal epithelium (tubules and podocytes) of 12 patients with confirmed systemic lupus erythematosus (SLE) and in 2 patients with probable SLE. They were not detected in renal biopsies from non-SLE patients. Morphologically, they suggest togavirus-like particles.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00430618
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  • 7
    Electronic Resource
    Electronic Resource
    Etude ultrastructurale des corps ultimobranchiaux du poulet (1969)
    Springer
    Cell & tissue research 94 (1969), S. 495-512 
    Details
    ISSN: 1432-0878
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Résumé Les corps ultimobranchiaux du poulet sont constitués de cordons glandulaires composés de cellules principales sécrétrices et de cellules bordantes. D'après le diamètre des grains de sécrétion, on peut distinguer au moins deux types de cellules principales, les cellules à petits grains (autour de 200 mμ) et les cellules à gros grains (250–300 mμ). Cette variation morphologique n'implique pas obligatoirement des sécrétions hormonales différentes. Les grains de sécrétion ne sont pas conservés par la fixation osmiée simple; ils se comportent sur ce point comme ceux des cellules parafolliculaires thyroïdiennes du mammifère dont les corps ultimobranchiaux représentent probablement les homologues fonctionnels. Les corps ultimobranchiaux du poulet restent actifs durant toute la vie de l'animal. L'apparition constante de formations folliculaires et kystiques, qui augmentent avec l'âge, ne traduit pas une involution globale de la glande. L'étude du développement embryonnaire permet d'expliquer certaines particularités morphologiques des corps ultimobranchiaux. Les premiers signes d'activité sécrétoires sont décelables à 11 jours d'incubation. La glande paraît très active vers la fin de la vie embryonnaire; un stockage important de matériel sécrétoire s'observe immédiatement après l'éclosion.
    Notes: Summary The ultimobranchial body of the chick consists of glandular cords made up of main secretory cells and supporting cells. According to the diameter of the secretory granules at least two main cell types can be distinguished: cells with small granules (200 mμ) and cells with large granules (250–300 mμ). This morphological difference does not necessarily implicate different hormonal secretions. The secretory granules are not preserved by simple osmium fixation; in as much as this point is concerned they behave like the granules of the parafollicular thyroid cells of mammals with which the ultimobranchial bodies are probably homologous. The ultimobranchial body of the chick remains active during the whole life of the animal. The constant appearance of follicular and cystic structure, which increase with aging, does not demonstrate an overall involution of the gland. The study of the embryonic development explains different morphological pecularities of the ultimobranchial body. The first indications of secretory activity are seen eleven days after incubation. The gland appears to be highly active towards the end of the embryonic life. An important accumulation of secretory material is observed immediately after hatching.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00936056
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  • 8
    Electronic Resource
    Electronic Resource
    Morphologie fine d'une differenciation glandulaire du recessus infundibulaire chez le rat (1966)
    Springer
    Cell & tissue research 69 (1966), S. 381-394 
    Details
    ISSN: 1432-0878
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Resumé Dans le tiers postérieur du recessus infundibulaire du Rat existe une zone périventriculaire colorable par le P.A.S. dont l'étude ultrastructurale révèle les caractères glandulaires L'intervention possible de cette ≪glande infundibulaire périventriculaire≫ dans la régulation de certaines fonctions antéhypophysaires est discutée.
    Notes: Summary An alcohol-choroform insoluble periodic acid — Schiff reactive substance associated with the ependymal lining of the infundibular recess was demonstrated in the hypothalamus of the white rat. Electronmicroscopic studies revealed the glandular character of this zone. The possible role of this “infundibular periventricular gland” in the regulation of anterior pituitary functions is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00406290
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  • 9
    Electronic Resource
    Electronic Resource
    B-cells of the synovial membrane (1978)
    Springer
    Cell & tissue research 187 (1978), S. 251-261 
    Details
    ISSN: 1432-0878
    Keywords: Synovial membrane ; B-cells ; Dense secretory vesicles
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Comparative ultrastructural study of the B-cells in the intimai layer of the synovial membrane in mouse, rat, rabbit, guinea-pig and man clearly distinguishes these cells from both the histiocytic A-cells (macrophage-like cells) and the fibroblasts. In addition to the marked development of the rough endoplasmic reticulum and Golgi apparatus, typical dense secretory vesicles apparently of Golgi origin are always found in mouse B-cells and frequently in those of the rat. These secretory characteristics clearly relate these cells to glandular cells engaged in polypeptidic secretion. The variations in the other species studied concern only the figuration of secretory material. Thus, the B-cells appear to constitute a category of secretory cells specific to the synovial membrane, but the function of which has yet to be determined.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00224368
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  • 10
    Electronic Resource
    Electronic Resource
    Influence des variations expérimentales de la calcémie sur la morphologie fine des cellules C du rat et du poulet (1972)
    Springer
    Cell & tissue research 128 (1972), S. 347-365 
    Details
    ISSN: 1432-0878
    Keywords: C cells ; Thyroid ; Ultimobranchial body ; Experimental modifications
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Résumé Les expériences d'hypercalcémie aigües et chroniques provoquent chez le rat des modifications spectaculaires des cellules C. Ces résultats sont en accord avec les données physiologiques sur la sécrétion de calcitonine chez le mammifère. Chez le poulet, par contre, les mêmes expériences ne provoquent pas de modifications indiscutables des Corps ultimobranchiaux (C.U.B.). Seule, l'injection intraveineuse de calcium provoque une dégranulation d'ailleurs partielle et assez peu accusée, des cellules C. L'inertie réactionnelle des C.U.B., que nous constatons morphologiquement, ressort également des données contradictoires sur le rôle physiologique de la calcitonine chez l'oiseau.
    Notes: Summary Acute and chronic hypercalcemia in rats induce spectacular modifications of the C cells. These results are in agreement with the physiological data on calcitonin secretion in mammals. The same experiments in chickens, however fail to provide a net modification of the ultimobranchial body. Only an intravenous injection of calcium induces degranulation of the C cells, and even then, this is partial and hardly evident. The lack of the ultimobranchial body response as observed in our morphological study may be compared with the conflicting physiological data on the role of calcitonin in birds.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00306975
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