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  • 1
    Electronic Resource
    Electronic Resource
    Temporal Blood Pressure Patterns in Children (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 783 (1996), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1996.tb26719.x
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  • 2
    Electronic Resource
    Electronic Resource
    Book review (1995)
    Springer
    Pediatric nephrology 9 (1995), S. 637-637 
    Details
    ISSN: 1432-198X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00860963
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Unexpected seizures during hemodialysis (1987)
    Springer
    Pediatric nephrology 1 (1987), S. 597-601 
    Details
    ISSN: 1432-198X
    Keywords: Hemodialysis ; Seizures ; Electroencephalogram ; Disequilibrium ; Osmolality ; Bicarbonate ; Acetate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To assess the effects of the dialysate prescription on the intradialytic neurological stability of children requiring chronic hemodialysis (HD), continuous EEG monitoring (CEM) was performed on five children before, during and after HD against: (1) low sodium acetate (LAc: Na 132 mEq/l, acetate 38 mEq/l); (2) high sodium acetate (HAc: Na 144 mEq/l, acetate 41 mEq/l), and (3) low sodium bicarbonate (LBi: Na 133 mEq/l, bicarbonate 35 mEq/l) dialysate. Three children, two with clinically well-controlled seizure disorders and one with no seizure history, exhibited subclinical seizures on LAc and HAc but improved neurological stability on LBi. Two children had essentially unchanged CEM studies on any HD regimen. Symptoms of disequilibrium were noted in four of the five children on LAc, two of the five on HAc and only one of the five on LBi. The data suggest that bicarbonate HD may enhance intradialytic neurological stability, particularly in children with known seizure disorders. Furthermore, CEM was found to be a useful tool for evaluating the neurological stability of children during HD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00853594
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  • 4
    Electronic Resource
    Electronic Resource
    Pancreatitis in children on chronic dialysis treated with valproic acid (1990)
    Springer
    Pediatric nephrology 4 (1990), S. 259-261 
    Details
    ISSN: 1432-198X
    Keywords: Pancreatitis ; Amylase ; Valproic acid ; Peritoneal dialysis ; Hemodialysis ; End-stage renal failure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Four children treated with maintenance dialysis, three peritoneal and one hemodialysis, developed pancreatitis while receiving valproic acid (VPA) for chronic seizure disorders. Two patients recovered, eventually resuming VPA therapy after successful cadaveric renal transplantation. Two children died after complications of pancreatitis. No episodes of pancreatitis occurred in the other 74 children in this maintenance dialysis population; none of whom received VPA. Although pancreatitis is a known complication of VPA treatment or end-stage renal disease (ESRD), this is the first reported series specifically relating pancreatitis to VPA administration in children treated with maintenance dialysis. The literature related to the association of pancreatitis with VPA administration and ESRD therapy is briefly reviewed and the clinical implications are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00857671
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  • 5
    Electronic Resource
    Electronic Resource
    Fungal peritonitis in children treated with peritoneal dialysis and gastrostomy feeding (1991)
    Springer
    Pediatric nephrology 5 (1991), S. 620-621 
    Details
    ISSN: 1432-198X
    Keywords: Fungal peritonitis ; Gastrostomy ; Peritoneal dialysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Feeding gastrostomies were placed in three children treated with chronic peritoneal dialysis at our center because of persistent, severe malnutrition and inadequate growth. Two had frequent fungal infections of the gastrostomy site and all three developedCandida peritonitis which occurred at 1 month, 2 months and 2 years after insertion of gastrostomy. Complications included multiple intra-abdominal adhesions, abscess formation and loss of peritoneal function necessitating transfer to hemodialysis. The presence of a gastrostomy may predispose to the development of fungal peritonitis with its high morbidity and should be avoided in children on chronic peritoneal dialysis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00856656
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  • 6
    Electronic Resource
    Electronic Resource
    Serial estimation of glomerular filtration rate in children after renal transplant (1999)
    Springer
    Pediatric nephrology 13 (1999), S. 737-741 
    Details
    ISSN: 1432-198X
    Keywords: Key words Transplantation ; Glomerular filtration rate ; Risk factor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Evaluation of serial monthly estimated glomerular filtration rate (eGFR) may be useful for studying pediatric renal allograft outcome. To determine the validity of this approach, we reviewed our single-center experience in pediatric renal transplant recipients to determine the effect of risk factors for renal allograft failure on eGFR. Clinical parameters recorded monthly through 5 years post transplant allowed serial assessment of eGFR. Monthly clinical data included height, weight, serum creatinine, cumulative number of acute rejection episodes, cyclosporine dose, and cyclosporine trough levels. From these data, eGFR was calculated monthly for each patient using the Schwartz formula. Time post transplant was grouped in 6-month intervals and plotted against mean eGFR to compare eGFR in patients grouped by demographic and clinical factors; 1,786 monthly data sets from 6 months post transplant (n=76 patients) to 5 years post transplant (n=25 patients) were analyzed. Overall mean eGFR from 6 months to 1 year was 75 ml/min per 1.73 m2 and from 4.5 to 5 years 46 ml/min per 1.73 m2. eGFR was lower at all time intervals for recipients of cadaver versus living-related donor grafts, and patients with ≥1 versus 0 acute rejections (P〈0.01). After 1 year, eGFR was lower in black patients compared with white or Hispanic patients (P〈0.01). Cyclosporine dose greater than 5 mg/kg per day was associated with better early and worse late graft function. These results are similar to those reported in multi-center studies using the outcome variable of graft failure and suggest that serial eGFR may be valid as an outcome variable to study chronic renal allograft dysfunction in children.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004670050690
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  • 7
    Electronic Resource
    Electronic Resource
    A limited sampling strategy for the estimation of Neoral AUCs in pediatric patients (1999)
    Springer
    Pediatric nephrology 13 (1999), S. 742-747 
    Details
    ISSN: 1432-198X
    Keywords: Key words Neoral ; AUC ; Pharmacokinetics ; Limited sampling strategy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The improved pharmacokinetics of Neoral allows the development of an accurate estimate of the full area under the concentration time curve (AUC) from a limited sampling strategy. As no such strategy has been derived from pharmacokinetic data obtained from children on 12-hourly dosing, and as patient convenience demands shorter sampling times, we derived a limited sampling strategy from 45 AUCs obtained from 19 pediatric renal transplant patients by stepwise forward multiple regression, and prospectively tested them on a separate group of 49 AUCs obtained from 18 pediatric renal transplant patients. Full cyclosporine (CsA) AUCs were obtained from samples drawn pre dose (C0) and at 2, 4, 6, 8 and 12 h post dose (C2, C4, C6, C8, and C12). High-precision predictions of full AUC were obtained based on the formula: AUC = 444 + 3.69 × C0 + 1.77 × C2 + 4.1 × C4 (mean prediction error ± SD = 0.3 ± 6.4%, 95% confidence interval=–1.7% to 1.9%.) In conclusion, CsA exposure in pediatric renal transplant patients on 12-hourly Neoral dosing can be reliably predicted by an early time point-based limited sampling strategy in children. This formula has the advantage of obtaining trough as well as AUC from one brief, convenient sampling period.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004670050691
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  • 8
    Electronic Resource
    Electronic Resource
    Treatment of an infant withCandida cystitis (1991)
    Springer
    Pediatric nephrology 5 (1991), S. 270-270 
    Details
    ISSN: 1432-198X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01095969
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  • 9
    Electronic Resource
    Electronic Resource
    Clinical uses of ambulatory blood pressure monitoring (1994)
    Springer
    Pediatric nephrology 8 (1994), S. 367-376 
    Details
    ISSN: 1432-198X
    Keywords: Ambulatory blood pressure monitor ; Hypertension ; Chronobiology ; Blood pressure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Traditional office measurements of blood pressure are commonly used to initiate and monitor therapy for hypertension, but these measurements are limited in their ability to provide information from the patient's normal work or play environment and do not include data from the overnight period when the patient is asleep. Thus, much potentially important information is lost. The ambulatory blood pressure monitor offers the attractive advantage of providing multiple blood pressure measurements from a subject's normal environment during his normal activities, thereby revealing important patterns of blood pressure in health and in illness. Further, the results of ambulatory monitoring have an excellent correlation with end-organ damage and these data can be obtained in a very short time period. This review will discuss the chronobiology of blood pressure, the clinical uses of the ambulatory blood pressure monitor in health and in disease, including the patterns of blood pressure identified, correlation with end-organ damage and its uses in clinical trials of antihypertensive medications; the experience in children with this technology will also be discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00866367
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