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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of medicinal chemistry 29 (1986), S. 1281-1284 
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Psychophysiology 14 (1977), S. 0 
    ISSN: 1469-8986
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: Classical conditioning experiments which employ CS-US intervals shorter than the latency of the CR, and which therefore require interspersed CS-alone test trials to assess conditioning, are open to the stimulus-sequence-change-elicited (SSCE) OR argument. The form of the SSCE argument which denies associative status to SCRs elicited by the CS-alone test trials is here termed an “empirical red herring” because: a) the argument cannot be dismissed on purely logical grounds, but requires the assessment of evidence for its examination; b) the argument enjoys empirical plausibility in the minds of the scientific community, as evidenced by published statements in both experimental articles and textbook chapters on autonomic conditioning; c) critical examination of the evidence which apparently supports the argument reveals that while the argument has provided a fascinating byway in the progress of our understanding of SCR conditioning, it is now time to bid farewell to the argument since it lacks any genuine empirical base. In the course of examining this particular argument, both the advantages and disadvantages of such arguments for scientific progress are discussed. Finally, it is emphasized that if one wants to study multiple-response phenomena in SCR conditioning, then a longer CS-US interval is clearly desirable. Our message only is that if the aim is to study SCR conditioning—defined as an increase in responding to a CS relative to some appropriate control condition(s) which is attributable to the contiguity of the CS with the UR to the US—in its most robust form, then the short-interval CS-US arrangement should not be avoided on the basis of the SSCE argument which, on examination, turns out to be an empirical red herring.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1469-8986
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: The primary aims are to elaborate on and clarify two general issues which are raised in the context of assessing contingency theory: (a) the operational requirements and the psychophysical considerations for assessing autonomic excitatory and inhibitory factors in Pavlovian conditioning, and (b) the topic of the appropriate CR specification in the autonomic electrodermal system. Our substantive conclusion, based on an evaluation of the methodology of available human autonomic studies, is that there is no empirical support for the contingency truly random control procedure. In addition, contrary to the suggestion of striking analogies with the skeletal eyelid system, a latency criterion should not be used to deny associative status to first-interval electrodermal responses, provided that these do satisfy conventional behavioral criteria for associative conditioning, e.g., discrimination.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Psychophysiology 15 (1978), S. 0 
    ISSN: 1469-8986
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1520-5118
    Source: ACS Legacy Archives
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of agricultural and food chemistry 40 (1992), S. 1385-1388 
    ISSN: 1520-5118
    Source: ACS Legacy Archives
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-2072
    Keywords: Tolerance ; Alcohol ; Memory ; Alcoholics ; Neuropsychological functioning
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The evidence on tolerance to the effects of alcohol on memory functions is conflicting. Comparisons of populations differing in drinking history (alcoholics versus normal subjects) provide clear evidence of tolerance to alcohol's effect in many indices of psychomotor performance, but not to impairment of recall by alcohol. In contrast, acute or intrasessional tolerance to alcohol's effect on memory has been demonstrated. In the context of a larger experiment on the acquisition of tolerance in nonalcoholic subjects an assessment of the effects of repeated daily exposure to alcohol on verbal recall was possible. The experimental design incorporated 3 baseline days prior to the administration of alcohol, 10 consecutive days of exposure to alcohol (1.0 g/kg test dose, with supplementary 0.9 g/kg after testing) and 3 further days on which no alcohol was administered. Data on seven subjects were available for the memory task, which consisted of free recall of lists of 24 words grouped into six categories of four words each. On each day, recall was assessed both prior to and following the administration of a control beverage or alcohol. Alcohol reduced the number of words recalled (P〈0.005) and, with repeated exposure, the impairment of recall by alcohol was reduced (P〈0.005) providing evidence of tolerance. The effect of alcohol and the development of tolerance were reflected primarily in the number of categories represented in recall, whereas the number of words recalled per category was relatively unaffected by alcohol. It was conjectured that previous failures to find tolerance to alcohol's effect on memory may reflect deficits in neuropsychologic functioning resulting from years of heavy drinking.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Psychopharmacology 74 (1981), S. 54-57 
    ISSN: 1432-2072
    Keywords: Cross-tolerance ; Ethanol ; Pavlovian conditioning ; Pentobarbital ; Tolerance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Tolerance to several effects of a number of drugs has been shown to depend on Pavlovian conditioning processes. Experiment I extended the compensatory conditioning model (Siegel 1975) to tolerance to the hypothermic effect of pentobarbital (30 mg/kg). In Experiment I, rats that acquired hypothermic tolerance in one environment did not display tolerance when tested in an environment not previously associated with drug administration. In Experiment II, rats were made tolerant to the hypothermic effect of pentobarbital (30 mg/kg) and tested for cross-tolerance to ethanol (2.5 g/kg). Cross-tolerance was observed, but it was significantly reduced if the test was in an environment different from the one in which tolerance to pentobarbital was originally acquired. Thus, the compensatory conditioning model accounts for at least part of the tolerance and crosstolerance to the thermic effects of alcohol and pentobarbital. The physiological processes in the CNS underlying tolerance and cross-tolerance for these drugs, therefore, are controlled by associative processes.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-2072
    Keywords: Conditioning ; Tolerance ; Alcohol ; Temperature ; Conditional stimuls
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To assess the effectiveness of a pharmacological cue as a conditional stimulus in the Pavlovian model of drug tolerance, two groups of Wistar rats received equal numbers of IP injections of a low and a high dose of alcohol. One group (Paired) received a low dose (0.8 g/kg) of alcohol followed 60 min later by the high dose (2.5 g/kg). Another group (Unpaired) received the low and high doses on an unpaired basis. When tested for tolerance to the hypothermic effect of the high dose of alcohol, only the Paired group showed tolerance, and only if the low dose preceded the high. When a saline injection preceded the high dose injection, the Paired group showed a loss of tolerance. The Paired group also showed a compensatory hyperthermia following the low dose injection. Animals from the Paired group that received repeated administrations of the low dose followed by saline, showed a significant extinction effect as compared with animals that received repeated saline injections only. These findings support the Pavlovian model of conditional tolerance, extending the realm of effective conditional stimuli to include a low dose of a drug.
    Type of Medium: Electronic Resource
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