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  • 1
    Electronic Resource
    Electronic Resource
    Prophylactic co-trimoxazole and trimethoprim in the management of urinary tract infection in children (1988)
    Springer
    Pediatric nephrology 2 (1988), S. 12-17 
    Details
    ISSN: 1432-198X
    Keywords: Urinary tract infection ; Co-trimoxazole ; Trimethoprim ; Vesico-ureteric reflux ; Low-dose prophylaxis ; Recurrence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In a prospective study of low-dose antibacterial prophylaxis of childhood urinary tract infection (UTI), co-trimoxazole and trimethoprim (TMP) have been compared for efficacy in preventing UTI, for their effect on the rectal flora and for secular selection of TMP-resistant organisms. Between 1979 and 1986, 334 children who had proven infection of an unobstructed urinary tract complied in a regimen of low-dose prophylaxis together with measures to eliminate residual urine for at least 6 months. Of these children, 167 had vesico-ureteric reflux and 27 had renal scarring. There was no difference between the two drugs in compliance, which was very good, or in the occurrence of side-effects, which were minimal. Recurrence rates of further infection were 1 per 22 child years for the 226 children receiving cotrimoxazole and 1 per 18 child years for the 108 receiving TMP. All but one of these urinary pathogens were resistant to TMP and reinfection of the urinary tract generally occurred following lapses in attention to complete bladder emptying. Neither a secular increase in recurrent infections during this period, nor a significant change in the proportions of TMP-resistant faecal coliform organisms, was observed. TMP and co-trimoxazole appeared to be equally effective prophylactic agents.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00870372
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Urinary proteins in vesicoureteric reflux: when the same thinking leads to different conclusions (1994)
    Springer
    Pediatric nephrology 8 (1994), S. 785-786 
    Details
    ISSN: 1432-198X
    Keywords: Urinary proteins ; Vesicoureteric reflux ; Vesicoureteric reflux ; Urinary retinol binding protein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00869126
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Differential excretion of urinary proteins in children with vesicoureteric reflux and reflux nephropathy (1994)
    Springer
    Pediatric nephrology 8 (1994), S. 21-25 
    Details
    ISSN: 1432-198X
    Keywords: Retinol-binding protein ; N-Acetyl-β-d-glucosaminidase ; Albuminuria ; Vesicoureteric reflux ; Reflux nephropathy ; Urinary tract infection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We studied 40 children with a history of vesicoureteric reflux (VUR) without evidence of renal scarring, 93 children with a history of VUR and renal scarring and 10 children with previous urinary tract infections in whom the urinary tract was radiologically normal. Urine retinol-binding protein (RBP), albumin andN-acetyl-β-d-glucosaminidase (NAG) were measured in each child. All were free from infection at the time of the analysis. Urinary RBP and NAG levels were significantly elevated (P〈0.001) in the group of children with renal scarring. Elevated RBP levels were detected in 51% of children with bilateral renal scarring compared with 7% of children with unilateral scarring. Urine RBP excretion increased progressively according to the type of scarring, best determined by the type of scarring of the less affected kidney. In children with renal scarring, elevated NAG levels were seen mostly in the 65 children with bilateral scarring and severe reflux. Urine albumin excretion was elevated in 10 children, 9 with bilateral scarring, all of whom had elevated RBP excretion. Urine protein excretion was unaffected by the presence or absence of persisting VUR. There was a strong negative correlation between glomerular filtration rate and RBP excretion (r=−0.69). We conclude that evidence of tubular dysfunction is common in children with bilateral renal scarring and usually precedes any glomerular protein leak. Tubular dysfunction may be the consequence of relative nephron hyperperfusion in the presence of bilateral scarring.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00868252
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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