ISSN:
1435-1803
Keywords:
calcium agonists
;
coronary pharmacology
;
hemodynamics
;
positive inotropic agents
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The hemodynamic effects of the dihydropyridine derivative Bay k 8644, a new calcium agonist with positive inotropic actions, were studied in instrumented conscious dogs before and after beta adrenergic blockade with propranolol. Intravenous Bay k 8644 (2, 4, 8 and 20 μg/kg/min) produced dose-related increases in arterial and left ventricular systolic pressures and myocardial contractility (+dP/dt; % segment shortening). Coronary blood flow velocity was increased at higher doses. Prior administration of propranolol produced no significant alteration of the hemodynamic effects of Bay k 8644. Increases in arterial and left ventricular pressures produced by Bay k 8644 were controlled by intravenous infusion of sodium nitroprusside with resulting enhancement of positive inotropic effects. The results demonstrate that the hemodynamic responses to this novel calcium agonist with positive inotropic properties are not mediated via beta adrenergic mechanisms and control of increases in arterial pressure lead to enhanced regional contractility.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01907908
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