ISSN:
1432-0738
Keywords:
Key words β-Cyclodextrin
;
Oncogenicity
;
Rat
;
Mouse
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The results of oncogenicity studies of β-cyclodextrin in inbred Fischer 344 rats and CD-1 outbred mice are presented. Chronic feeding of β-cyclodextrin to Fischer 344 rats and CD-1 mice did not cause any treatment related carcinogenic effects. The only toxic effect was seen in mice as macroscopic distension of the large intestine with soft or fluid contents, histologically associated with the mucosa covered by mucous secretion containing exfoliated cells, and mucosal flattening and intestinal gland atrophy. Despite these observations, no differences between control and treated groups were observed concerning mortality, clinical observations or body weight and food consumption.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002040050224
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