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  • 1
    Electronic Resource
    Electronic Resource
    Induction of Melanotic Tumours in the White (‘Partial Albino’) Syrian Hamster (1961)
    [s.l.] : Nature Publishing Group
    Nature 189 (1961), S. 936-937 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In our experiments, initiated without knowledge of those of Illman and Ghadially6, 10 male and 10 female random-bred white hamsters, 4 months old at the start, were treated once weekly for 3 consecutive weeks with a 1 per cent solution of DMBA (Eastman) in mineral oil, essentially the same ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/189936a0
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  • 2
    Electronic Resource
    Electronic Resource
    PIGMENTATION AND PIGMENARY DISORDERS. NORMAN LEVINE, ED. CRC PRESS, BOCA RATON, 1993. (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Periodontology 2000 7 (1994), S. 0 
    Details
    ISSN: 1600-0757
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0749.1994.tb00062.x
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  • 3
    Electronic Resource
    Electronic Resource
    Molecular Genetics and the Ontogeny of Pigment Patterns in Mammals (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Periodontology 2000 5 (1992), S. 0 
    Details
    ISSN: 1600-0757
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The conclusion that animal development is guided by a hierarchical system of gene expression and interaction has gained considerable support from recent molecular genetic studies on fruit flies (Drosophila melanogaster) and mice (Mus musculus). They demonstrate that the patterns of organization revealed by terminal differentiation of cells is anticipated by a myriad of transient prepatterns that channel the developing embryo toward its genetically-programmed target. The numerous white spotting mutants in mice exhibit some of the most dramatic and variable patterns of cutaneous melanin pigmentation. Until recently, the mechanisms of action of white spotting genes and their relationship to the developmental genetic hierarchy remained unknown. It now appears that certain white spotting genes may encode growth factors essential for melanoblast development. Others may be related to homeobox genes that play a number of developmental roles, the primary one being the determination of regional organization along the anterior-posterior axis of the early embryo. The patterns of homeobox gene expression are consistent with several of the developmental models for white spotting in mice and other mammals. It is evident that white spotting genes are not solely concerned with the terminal differentiation of melanoblasts into melanocytes. They are heterogeneous with regard to action and level of expression within the developmental hierarchy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0749.1992.tb00557.x
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  • 4
    Electronic Resource
    Electronic Resource
    The BULT Melanoma: A Spontaneous Transplantable Tumor in Mice (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Periodontology 2000 1 (1988), S. 0 
    Details
    ISSN: 1600-0757
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The BULT melanoma originated at Brown University as a spontaneous, small black nodule on the tail of an adult female mouse of the LT/Ch strain. Histological examination of a portion of the tumor indicated that it was intradermal and consisted predominantly of heavily melanized, ovoid to fusiform cells with melanin-laden macrophages scattered among them. The BULT melanoma has been maintained in LT/Ch mice for approximately 5 years by periodic transplantation, at first subcutaneously on the flanks and, more recently, intramuscularly in the hind legs. The shift in transplantation site was made following a marked decline in the growth of subcutaneous grafts.The transplants have retained the uniform deep-black melanization and general histology of the primary melanoma. Numerous melanosomes at all stages of development are found within the melanoma cells. DOPA-positive cytoplasmic vesicles are abundant. Occasional autophagic vacuoles containing clusters of melanosomes are also present. A few metastases from the transplanted melanoma have been observed in lymph nodes and on one occasion in the lungs. When grown in vitro, BULT melanoma cells do not require special growth promoting agents (e.g., TPA; cAMP) in order to proliferate. The BULT melanoma differs in one or more respects from each of the other three transplantable spontaneous mouse melanomas widely used in cancer research. In addition, it arose in a strain of mice characterized by the spontaneous death of melanocytes while the latter are engaged in synthesizing eumelanin within hair follicles.Karyotypic analysis of cultured cells showed a modal chromosome number of 68 with a range of 58–72 chromosomes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0749.1988.tb00802.x
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  • 5
    Electronic Resource
    Electronic Resource
    The Shift from Physiological Genetics to Molecular Genetics in the Study of Mouse Tyrosinase (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Periodontology 2000 3 (1990), S. 0 
    Details
    ISSN: 1600-0757
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0749.1990.tb00350.x
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  • 6
    Electronic Resource
    Electronic Resource
    Influence of Depigmenting Chemical Agents on Hair and Skin Color in Yellow (Pheomelanic) and Black (Eumelanic) Mice (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Periodontology 2000 3 (1990), S. 0 
    Details
    ISSN: 1600-0757
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Topical applications of monobenzylether of hydroquinone (MBEH) or intraperitoneal injections of phenol induced graying of hair in eumelanic mice but had little effect on hair color in pheomelanic mice. Amcinonide, an anti-inflammatory agent, elicited whitening of a few hairs in both pheomelanic and eumelanic mice. In phenol-treated eumelanic mice, damaged follicular melanocytes were uprooted from hair bulbs and incorporated into the developing hair. The fate of follicular melanocytes in MBEH- or amcinonide-treated mice was not determined since hair growth and graying were more variable than in phenol-treated mice.In contrast to the susceptibility of eumelanic hair follicles to depigmentation by phenol or MBEH, the tail skin of eumelanic or pheomelanic mice was not depigmented by these agents. Overall, during the 3 week period of treatment that was sufficient for phenol or MBEH to elicit graying of hair, epidermal melanocytes of the tails of eumelanic or pheomelanic mice either failed to respond (phenol) or were stimulated in their “proliferative” and melanogenic activity (MBEH). In contrast, amcinonide brought about a marked reduction in the numbers of DOPA-positive epidermal melanocytes inhabiting the tails of eumelanic or pheomelanic mice. Amcinonide exerted a deleterious influence on the structure and function of tail epidermis. Its actions were partly reversed by simultaneous treatment with MBEH but not with prostaglandin (PGE2).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0749.1990.tb00325.x
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  • 7
    Electronic Resource
    Electronic Resource
    Preface (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Periodontology 2000 5 (1992), S. 0 
    Details
    ISSN: 1600-0757
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0749.1992.tb00546.x
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  • 8
    Electronic Resource
    Electronic Resource
    Vertebrate Epidermal Melanin Unit (1966)
    [s.l.] : Nature Publishing Group
    Nature 209 (1966), S. 1334-1335 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] MELANIN pigmentation of mammalian epidermis involves the formation of melanin granules within meianocytes and their transfer to malpighian (receptoi) cells. The total intensity of epidermal pigmentation is related to the qualitative and quantitative attributes of melanin granules within both types ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/2091334a0
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  • 9
    Electronic Resource
    Electronic Resource
    A simple organ culture method for differentiation of melanocytes in mouse embryonic skin using “origami” membrane filter (1980)
    Springer
    Methods in cell science 6 (1980), S. 101-102 
    Details
    ISSN: 1573-0603
    Keywords: organ culture ; skin ; melanocyte ; mouse ; membrane filter
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary A simple organ culture method for culturing embryonic skin was developed. A piece of skin with a part of the neural tube from mouse embryo (11 to 12 d) was placed on a 25 mm d membrane filter. The filter was folded to wrap the explant and inserted into glass tubing. The explant and filter in the glass tubing were placed in a rotating tissue culture tube containing 5 ml culture medium (Ham's F12 supplemented with 15 to 20% fetal bovine serum) and filled with a mixture of 95% air:5% CO2. In explants cultured for 6 d fully differentiated melanocytes were observed in the epidermis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02082858
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  • 10
    Electronic Resource
    Electronic Resource
    Histological observations on the silvering process in the champagne d'Argent rabbit (1957)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 129 (1957), S. 87-95 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091290108
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