ISSN:
1432-2072
Keywords:
Orotic acid
;
Postnatal development
;
Memory retention
;
Brightness discrimination
;
Active avoidance
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract During the postnatal period, male Wistar rats were treated with orotate, either from the 6th to 15th, 16th to 25th, or 26th to 35th day of life. Learning and memory were tested in adulthood. Rats that received orotate from the 6th to 15th day showed a better retention of a learned brightness discrimination (Y-maze) than controls. An active avoidance (pole jumping) was learned more quickly by the rats orotatetreated from the 6th to 15th day than by controls. The spontaneous locomotor activity of previously orotatetreated rats was the same as in controls. Body weight measurements revealed no differences between orotate rats and control rats. The results suggest that memory retention in adulthood can be improved by postnatal orotate treatment.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00426916
Permalink
