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  • 1
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Recent data indicate that 5-aminosalicylic acid (5-ASA) is most effective in preventing relapse of Crohn's disease in patients with a short duration of remission before enrolment.〈section xml:id="abs1-2"〉〈title type="main"〉AimTo evaluate the efficacy of oral 5-ASA treatment, started immediately after achieving steroid-induced remission, in preventing clinical relapses of Crohn's disease.〈section xml:id="abs1-3"〉〈title type="main"〉MethodsPatients with active Crohn's disease, achieving remission on steroids, were randomized to oral 5-ASA 3 g/day or placebo, while steroids were tapered over 6 weeks. The trial was terminated after interim analysis showed a slightly higher relapse rate in the 5-ASA group, and the calculated probability of seeing a statistically significant difference by completing the study was minimal.〈section xml:id="abs1-4"〉〈title type="main"〉ResultsFinal analysis included 117 patients (58 taking 5-ASA and 59 taking placebo; follow-up 9.2 ± 6.5 months). Cumulative relapse rates at 6 and 12 months were 34% and 58% in 5-ASA patients and 31% and 52% in placebo patients, respectively (rate difference + 0.095; 95% CI = −0.085– + 0.274). Subgroups analysis showed that 5-ASA was equally ineffective in patients with ileal, colonic or ileocolonic disease.〈section xml:id="abs1-5"〉〈title type="main"〉ConclusionsContrary to previous results, in our study early introduction of treatment with oral 5-ASA did not prevent relapse in Crohn's disease patients treated with steroids to induce remission.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 120 (1989), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The authors analyse submicroscopic caracteristics of the infiltrate and the morphology and genesis of so-called “Langerhans' cell granules” in four cases of Letterer-Siwe's disease. Some giant cellular elements “main cells” were observed; their ultrastructure is similar to the Hodgkin and Sternberg cells of malignant lymphogranuloma, but clearly different from the normal histiocytic elements, epitheloid cells and also from the reticular cells of reticulosarcoma. Moreover in the skin of one of the studied patients numerous “Langerhans' cell”-like elements were found. The viral nature and the specifity of so-called “Langerhans' cell granules” is denied on the base of their morphology and of their localisation in different cellular elements.
    Notes: Zusammenfassung Die Verfasser untersuchten die ultramikroskopischen Charakteristica der Infiltrate und die Morphologie und Genese der sog. “Langerhans cell granules” bei vier Fällen von Letterer-Siwescher Erkrankung. Die zahlreichen, als “Hauptzellen” bezeichneten Riesenzellen haben ultrastrukturelle Charakteristiken, die sehr an diejenigen der Zellen von Hodgkin und Sternberg bei malignem Lymphogranulom erinnern und eindeutig von normalen Histiocyten, Epitheloidzellen und den Zellen des Reticulosarkoms zu unterscheiden sind. In den Hauterscheinungen eines der Patienten wurden außerdem zahlreiche “Langerhans cell-like elements” beobachtet. Die Verfasser schließen die Spezifität und die virale Natur der sog. “Langerhans cell granules” auf Grund ihrer Morphologie und ihres Vorhandenseins in verschiedenen Zellarten aus.
    Type of Medium: Electronic Resource
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