ISSN:
1573-8221
Keywords:
GABA uptake
;
Na,K-ATPase
;
psychotropic drugs
;
rat brain synaptosomes
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Neurotropic drugs belonging to various groups (fluphenazine, nonachlazine, trifluperidol fluacizine, imipramine, diazepam, apomorphine fetanyl, diphenylhydantoin) in experiments in vitro showed an inhibitory effect on active transport of γ-aminobutyric acid (GABA) by synaptosomes of the rat cerebral cortex. In most cases a parallel decrease in the activity of synaptosomal Na,K-ATPase was observed. Substances not changing GABA uptake as a rule had no effect on the activity of the enzyme (carbidine and morphine). Some substances inhibiting Na,K-ATPase were ineffective with respect to GABA uptake (azabuperon, tetrabenazine). It is suggested that the drugs tested have at least two possible points of application: Na,K-ATPase and the hypothetical transmembrane carrier of GABA.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00800165
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