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  • 1
    Electronic Resource
    Electronic Resource
    Cyclic nucleotide exudation by nematodes and the effects on nematode growth, development and longevity (1980)
    Springer
    Age 3 (1980), S. 82-87 
    Details
    ISSN: 1574-4647
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The levels of the cyclic nucleotides, cAMP and cGMP, in the medium of aging mass cultures of Panagrellus redivivus were determined, respectively, by a protein binding assay and a radio-immunoassay. The amount of cGMP increased as the mass cultures aged while the amount of cAMP remained stable. Since premature death and an inhibition of development have been observed in aging mass cultures, investigators have speculated that a build-up of excretory products in the medium might be toxic to the nematodes and cause abnormal development. To examine this possibility, small cultures containing fixed numbers of the nematode Caenorhabditis elegans were exposed to levels of cGMP analagous to the levels found in aging mass cultures of P. redivivus. Significant increases in growth and longevity occurred with no effect on fecundity, timing or the duration of the reproductive period. It appears then that cGMP is not responsible for the toxic effects observed in mass culture and, in fact, cGMP apparently enhances nematode longevity at concentrations which do not alter normal development.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02432264
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Cell-cell interactions influence oligosaccharide modifications on mucins and other large glycoproteins (1996)
    Springer
    Glycoconjugate journal 13 (1996), S. 741-747 
    Details
    ISSN: 1573-4986
    Keywords: mucins ; oligosaccharides ; cell-cell interactions cancer ; aberrant expression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Intratumoral phenotypic diversity is well documented with regard to tumor associated carbohydrate antigens (TACA). The factors which control the expression of these cell-surface oligosaccharides on different cells of the same tumor are not understood. We investigated the expression of a panel of mucin associated oligosaccharides in cell lines growing at different surface densities (number of cells per cm2 of growth flask). Results show that the apparent expression of extended Lea-Lex, Lea and Lex, sialyl Lea, Tn and sialyl Tn varies with density of growth by an invasive human squamous cell lung carcinoma cell line (NU6-1), a benign variant (NE-18) and the human lung epithelial cell line BEAS-2B. The results indicate that one of the factors influencing the apparent expression of mucin-associated oligosaccharides is cell-cell interactions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00702338
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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