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  • 1
    Electronic Resource
    Electronic Resource
    Trichophyton tonsurans exocellular protease expression: correlation with clinical presentation in tinea capitis (2002)
    Oxford, UK : Blackwell Science Ltd
    Clinical and experimental dermatology 27 (2002), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Tinea capitis remains an overwhelmingly prevalent disease in children. Despite the fact that it was described over a century ago, disease pathogenesis remains incompletely characterized. This investigation was designed to evaluate whether inter-strain variability in fungal protease expression for clinical Trichophyton tonsurans isolates correlates with disease severity. Children with tinea capitis were enrolled and a clinical severity score (CSS) determined for all subjects by grading eight symptoms on a 4-point scale. Fungal specimens were collected by brush culture, placed in aqueous medium and incubated at 32 °C for 5 days. The culture supernatant was lyophilized and aliquots used to characterize protease activity. Enzyme activity, normalized to total soluble protein, varied 550-fold, 150-fold and 6-fold for collagenase, elastase and keratinase, respectively. A significant decrease in elastase and collagenase activity was observed with increasing duration of infection. In one-half of the children, CSS increased in direct response to collagenase and elastase production, while CSS was independent of enzyme activity in the remaining children. The relationship between enzyme activity and time course of disease are consistent with theories on enzyme regulation in dermatophytoses; however, the finding that two potential subsets of children exist with varied response to fungal antigens has yet to be described.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2230.2002.01602.x
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  • 2
    Electronic Resource
    Electronic Resource
    The nature of the ground state of Ce systems: CeM3 alloying studies of local moment to mixed valent transitions (1990)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 67 (1990), S. 5209-5211 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The often quoted view that the nature of the ground state of Ce systems is determined by a single parameter, namely Jsf, the conduction-electron f-electron coupling constant, is shown to be incorrect. In particular, the alloy series CeTl3→CePb3→CeSn3 and CeTl3→CeIn3→CeSn3 show ground state phase diagrams that are qualitatively different. Moreover, both differ drastically from the ground-state phase diagram obtained for the CeTl3→CeSn3 series which presumably spans the same range of Jsf. The CeTl3→CePb3→CeSn3 alloy series show local moment antiferromagnetism (LMAF)→itinerant heavy fermion antiferromagnetism (IHFAF)→mixed valent (MV) transitions. The other two series show only LMAF→MV transitions which differ significantly in their Jsf dependence. In addition, the concentration dependence of the ground-state evolutions in these systems is such that theoretical models which hold that the ground state is determined by two parameters, not one (namely the Rudermann–Kittel temperature TRKKY as well as Jsf), also appear to be inadequate to explain these findings. Corroborative evidence from studies of the CePb3→CeIn3 series will be presented. The possibility that substitutionally induced disorder plays an essential role in these systems, even though the alloying takes place on the non-Ce site, will be discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.344639
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  • 3
    Electronic Resource
    Electronic Resource
    Constraint effects on probabilistic analysis of cracks in ductile solids (2000)
    Oxford, UK : Blackwell Science Ltd
    Fatigue & fracture of engineering materials & structures 23 (2000), S. 0 
    Details
    ISSN: 1460-2695
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: This paper presents a method for evaluating constraint effects on probabilistic elastic–plastic analysis of cracks in ductile solids. It is based on fracture parameters J and Q, correlation between Q and J–resistance curve of the material, and J-tearing theory for predicting fracture initiation and instability in cracked structures. Based on experimental data from small-scale fracture specimens, correlation equations were developed for fracture toughness at crack initiation and the slope of the J–resistance curve as a function of constraint condition. The random parameters may involve crack geometry, tensile and fracture toughness properties of the material, and applied loads. Standard reliability methods were applied to predict probabilistic fracture response and reliability of cracked structures. The results suggest that crack-tip constraints have little effect on the probability of crack initiation. However, the probability of fracture instability can be significantly reduced when constraint effects are taken into account. Hence, for a structure where some amount of stable crack-growth can be tolerated, crack-tip constraints should be considered for probabilistic fracture-mechanics analysis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1460-2695.2000.00309.x
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  • 4
    Electronic Resource
    Electronic Resource
    Cultivation of Rumen Protozoa. I. Factors Influencing the Cultivation of Rumen Oligotrich Protozoa “In Vitro” (1964)
    Oxford, UK : Blackwell Publishing Ltd
    The @journal of eukaryotic microbiology 11 (1964), S. 0 
    Details
    ISSN: 1550-7408
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: SYNOPSIS. Factors influencing the cultivation of entodinia in vitro have been studied. It was found that removal of particulate material, culture division, or a combination of both resulted in similar maximum protozoal concentrations. At the same time, untreated culture concentrations declined rapidly after reaching a maximum concentration at about the tenth day.At concentrations of streptomycin greater than 25 μg per ml of media, increasing the level of streptomycin extended the time required for a culture to attain a maximum protozoal concentration. A significant relationship (P〉.01) was demonstrated between the starch concentration and the protozoal concentration, and it was found that various combinations of starch and streptomycin produced different relative protozoal concentrations in initial and established cultures. Implications arising from these results are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1550-7408.1964.tb01720.x
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  • 5
    Electronic Resource
    Electronic Resource
    Comparative Study of the Urease in the Rumen Wall and Rumen Content (1966)
    [s.l.] : Nature Publishing Group
    Nature 209 (1966), S. 618-619 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Preparation of cell-free extracts. Washed suspensions of ruminal bacteria were prepared from the rumen content of freshly slaughtered cattle6. The bacterial cells were broken up using an M.S.E. ultrasonic disintegrator for 15 min. Cell-free extracts were obtained by centrifugation at 75,000g for 30 ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/209618b0
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  • 6
    Electronic Resource
    Electronic Resource
    Co-carcinogenic effect of β-carotene (1999)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 398 (1999), S. 760-761 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Epidemiological and animal studies on vitamin A and its analogues support the hypothesis that β-carotene can prevent cancer in humans. However, chemoprevention trials have unexpectedly shown that β-carotene, either alone or in combination with vitamin A or vitamin E, actually ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/19655
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  • 7
    Electronic Resource
    Electronic Resource
    The local domain configuration in partially ordered AuCu3 (1993)
    [S.l.] : International Union of Crystallography (IUCr)
    Acta crystallographica 49 (1993), S. 68-79 
    Details
    ISSN: 1600-5724
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: If the videographic simulation method is applied, the real structure configuration of the domains formed in a partially ordered AuCu3 crystal is established. Each domain is formed by four ordered AuCu3 blocks. The blocks are interconnected crosswise by two different domain boundaries, namely the preferred antiphase domain boundary and the new domain interface structure (I cells of the composition Au2Cu6). Six symmetry-related domains exist with the above-mentioned domain structure. An AuCu3 crystal that shows the characteristic two- and fourfold splitting of the superlattice reflections in its diffraction pattern (of partial order) contains at least two such domain configurations at 90° relative to each other. A two- and three-dimensional simulation using different combination probabilities and structure variants allows a quantitative description of the real configuration of the AuCu3 structure at different temperatures to be made.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108767392005841
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  • 8
    Electronic Resource
    Electronic Resource
    Simulation of short-range order in f.c.c. alloys (1995)
    [S.l.] : International Union of Crystallography (IUCr)
    Acta crystallographica 51 (1995), S. 153-158 
    Details
    ISSN: 1600-5724
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: The videographic simulation algorithm has been further developed to enable any distribution or vector correlation among atoms or structure variants beyond the first shell. The simulation method is applied to Ni4Mo, Au4Mn and Cu3Au in order to describe their real structures above Tc. One of the main advantages of the method is the rapid calculation of the diffraction pattern from the simulated videographic structure image (parallel processing). Moreover, the three-dimensional simulation field can be analysed to determine the local atomic arrangement or to calculate short-range-order parameters. The method can generally be applied to simulate defect or vacancy distributions with a specific degree of correlation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108767394008925
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  • 9
    Electronic Resource
    Electronic Resource
    The videographic method: a new procedure for the simulation and reconstruction of real structures (1993)
    [S.l.] : International Union of Crystallography (IUCr)
    Acta crystallographica 49 (1993), S. 56-68 
    Details
    ISSN: 1600-5724
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: The videographic method is a simulation and reconstruction procedure that uses a statistical mathematical approach and computer graphics to aid the interpretation of scattering (X-ray, electron, neutron) from a disordered crystal. Based on the principles of optical transforms, and in contrast to it, atoms with different scattering power are represented as picture elements (pixels) with different grey levels. Compared with optical transforms, this method has the special advantage that holes of infinitely small radii can simulate different scattering powers in a mask. With the application of a statistical mathematical approach (combination probabilities), various scatterers, e.g. atoms, structure variants or domains, can be distributed in a two- or three-dimensional model. A Fourier transformation of the simulated model (diffraction pattern) can be calculated in a few s using an array processor and displayed for comparison with experiments. Real-structure image reconstruction can also be performed by amplitude and phase manipulation. As a starting model for a reconstruction, a randomly disordered structure is assumed. Under this assumption, a monotone diffuse background is obtained in the diffraction pattern. The principal idea in a reconstruction of an unknown real structure is that the diffuse regions of a partly ordered structure are a subset of the monotone diffuse background for a random disorder.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108767392005889
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  • 10
    Electronic Resource
    Electronic Resource
    Light heavy-fermions in Zn and Ni doped 123 Cu-O superconductors
    Amsterdam : Elsevier
    Physica B: Physics of Condensed Matter 163 (1990), S. 227-230 
    Details
    ISSN: 0921-4526
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0921-4526(90)90175-T
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