ISSN:
1573-4919
Keywords:
cell cycle
;
growth inhibition
;
Cyclic AMP
;
cyclic AMP-dependent protein kinase
;
nuclear protein phosphorylation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
Notes:
Summary A substantial increase in cyclic AMP-dependent protein kinase activity occurred in nuclei of PY815 mastocytoma cells during G1 phase growth arrest by DB cyclic AMP and the increased nuclear protein kinase was accompanied by changes in nuclear protein phosphorylation. However, there was no obligatory association between the rise in nuclear cyclic AMP-dependent protein kinase in G1 phase and growth arrest because nuclear cyclic AMP-dependent protein kinase also increased during G1 phase in cycling PY815 cells synchronized with amethopterin. These observations suggest that maintenance of high cyclic AMP levels during G1 phase may cause growth arrest by activating a cyclic AMP-dependent protein kinase that normally increases in PY815 cell nuclei during G1 phase.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00220983
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