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How GPCRs hit the switch (2006)

Ramachandran, Sekar ; Cerione, Richard A

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 13 (2006), S. 756-757

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] The GTP-binding–hydrolytic cycles mark the 'on' and 'off' states for G proteins in their ability to signal to downstream effector proteins. These cycles must be carefully regulated, as the hyperactivation of G proteins, either through constitutive GDP-GTP exchange or impaired GTP hydrolysis, ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb0906-756

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