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  • 1
    Electronic Resource
    Electronic Resource
    Immunohistochemical distribution patterns of epidermal growth factor receptor in malignant mesothelioma and non-neoplastic mesothelium (1991)
    Springer
    Virchows Archiv 419 (1991), S. 171-175 
    Details
    ISSN: 1432-2307
    Keywords: Epidermal growth factor receptor ; Mesothelioma ; Pleura ; Nuclear immunoreactivity ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An immunohistochemical study of the epidermal growth factor (EGF) receptor in non-neoplastic pleural mesothelium (35 cases) and in human malignant mesothelioma (36 cases) was made, using a murine monoclonal antibody OM-11-951. All malignant mesotheliomas and non-neoplastic pleural biopsies exhibited a strong cytoplasmic immunoreactivity in mesothelial cells. Nuclear immunoreactivity was detected in mesothelial cells of all specimens of both malignant and non-neoplastic pleura. No statistically significant differences were found between malignant mesothelioma and non-neoplastic pleural mesothelium. There were differences, between the three subtypes of mesothelioma, in the number of cells that exhibited nuclear staining. Statistically significant differences were noted between the epithelial subtype and the mesenchymal subtype (P〈 0.005), epithelial subtype versus the mixed cell type (P〈 0.005) and between the mesenchymal component of the mixed cell type and the mesenchymal type (P〈0.0005). We conclude that there is strong expression of EGF receptor in both malignant mesothelioma and in non-neoplastic pleural mesothelium. Different staining patterns are seen when comparing the different subtypes of mesotheliomas with each other. EGF receptor expression cannot be used to distinguish between malignant and benign mesothelium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01626344
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    GlutathioneS-transferase expression in malignant mesothelioma and non-neoplastic mesothelium: an immunohistochemical study (1996)
    Springer
    Journal of cancer research and clinical oncology 122 (1996), S. 619-624 
    Details
    ISSN: 1432-1335
    Keywords: GlutathioneS-transferase (GST) ; P-170 glycoprotein ; Mesothelioma ; Immunohistochemistry ; Survival
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Expression of the glutathioneS-transferase (GST) subclasses α, μ and π was investigated immunohistochemically in 20 normal or hyperplastic mesothelium and in 57 malignant mesothelioma cases. These results were correlated with survival and also with P-170 glycoprotein expression. Nearly all the non-neoplastic mesothelium cases were positive for GSTα and π. About half of the non-neoplastic cases were positive for μ. Twenty-nine (51%) malignant mesotheliomas were positive for at least one of the GST species; 21 (37%) showed immunoreactivity for α, 18 (31.5%) for μ and 21 (37%) for π. A total of 54 mesothelioma cases displayed immunoreactivity for the P-170 glycoprotein. For GSTπ and GSTμ, a statistical significance between expression and increased survival was found (respectivelyP=0.012 and 0.024) while for GSTα no significance was found. The results of this study demonstrate that expression of GSTπ correlates positively with increased survival in malignant mesothelioma. It is also concluded that, in mesothelioma, GST and P-170 glycoprotein may contribute to the resistance to cytotoxic drugs frequently observed in these tumours. No correlation between GST and P-170 expression was demonstrated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01221194
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Detection of human papillomavirus in cervical scrapings by in situ hybridization and the polymerase chain reaction in relation to cytology (1995)
    Springer
    Journal of molecular histology 27 (1995), S. 54-59 
    Details
    ISSN: 1573-6865
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A gynaecological out-patient population consisting of 200 patients aged 19–43 years (mean age 34.2 years) was screened for the presence of human papillomavirus (HPV) by the polymerase chain reaction and in situ hybridization on cervical scrapings. A novel method was applied for the detection of HPV in cervical cells by embedding them in a paraffin block before in situ hybridization was performed. This technique resulted in well preserved cytological morphology, easy performance and economy of probes. In eight of the 200 patients (4%), human papillomavirus DNA was revealed by the polymerase chain reaction. Subtyping revealed the presence of HPV serotype 16 DNA in three of these patients. In one patient HPV serotype 18 DNA was also present. The in situ hybridization assay was able to detect all those cases with a specific HPV serotype infection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00164172
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    Paper (German National Licenses)
    Fulltext
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