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  • 1
    ISSN: 1460-9568
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: The chondroitin sulphate proteoglycan brevican is one of the most abundant extracellular matrix molecules in the adult rat brain. It is primarily synthesized by astrocytes and is believed to influence astroglial motility during development and under certain pathological conditions. In order to study a potential role of brevican in the glial reaction after brain injury, its expression was analysed following entorhinal cortex lesion in rats (12 h, 1, 2, 4, 10, 14 and 28 days and 6 months post lesion). In situ hybridization and immunohistochemistry were employed to study brevican mRNA and protein, respectively, in the denervated outer molecular layer of the fascia dentata and at the lesion site. In both regions brevican mRNA was upregulated between 1 and 4 days post lesion. The combination of in situ hybridization with immunohistochemistry for glial fibrillary acidic protein demonstrated that many brevican mRNA-expressing cells are astrocytes. In the denervated zone of the fascia dentata, immunostaining for brevican was increased by 4 days, reached a maximum by 4 weeks and remained detectable up to 6 months post lesion. Electron microscopic immunocytochemistry showed that brevican is a component of the extracellular matrix compartment. At the lesion site a similar time course of brevican upregulation was observed. These data demonstrate that brevican is upregulated in areas of brain damage as well as in areas denervated by a lesion. They suggest a role of brevican in reactive gliosis and are compatible with the hypothesis that brevican is involved in the synaptic reorganization of denervated brain areas.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Springer
    Cell & tissue research 290 (1997), S. 349-356 
    ISSN: 1432-0878
    Schlagwort(e): Key words: Extracellular matrix ; Proteoglycans ; Tenascin ; Hyaluronan ; Brain
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract.  An increasing number of extracellular matrix molecules has been identified in the brain over the last couple of years. Various interactions have been identified between some of these molecules, indicating that they are components of an organized matrix. In this review, an attempt is made to arrive at a model for such a matrix, based on the current knowledge of the structure and interactions of these molecules.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Springer
    Environmental geochemistry and health 22 (2000), S. 233-248 
    ISSN: 1573-2983
    Schlagwort(e): Berlin agglomeration ; environment ; environmental geochemistry ; geochemical background ; soil contamination ; trace elements ; urban geochemistry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Geologie und Paläontologie , Medizin
    Notizen: Abstract The distribution of 41 trace and 11 major elements in 4000 samples of topsoils (0–20 cm) from the Berlin Megacity is interpreted. The detailed comparative analysis of the element distributions and the results of factor analysis showed that the distributions of the elements Al, K, Na, Rb, Zr, Nb and Ti are mainly natural origin, i.e. related to the composition of the parent material. Industrial and commercial areas often display considerably elevated values for Mo, Ni, As, Ag, Cr, Sb, Fe, Mn, Mg, P, TOC and especially Pb, Hg and electrical conductivity relative to the geogenic background of the area surrounding Berlin. Industrial areas tend to be characterised by contamination of the subsoil with Cu, Cd, Zn, Hg, Pb and Sn. In the area around Berlin, extensive, strong anamalies of Cd, Zn, Pb, Cu and Hg occur near iron and steel industries and construction materials industries, as well as in the vicinity of sewage farms.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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