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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 534 (1988), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background : Differences in risk factors for survival and recurrence after liver resection for hepatocellular carcinoma (HCC) in patients with or without cirrhosis are not fully clarified.Aim : To review a single-centre experience of curative liver resections for HCC in order to evaluate clinicopathologic features and the long-term outcome of cirrhotic and noncirrhotic patients.Methods : From 1981 to 2002, 308 curative liver resections for HCC on cirrhosis (Group 1) and 135 for HCC without cirrhosis (Group 2) were performed. The main demographic, clinicopathologic and operative parameters, as well as early results were analysed and compared. Overall and disease-free survival were evaluated. Prognostic factors for survival and for tumour recurrence were studied by univariate and multivariate analysis.Results : Group 1 had worse preoperative liver function and higher frequency of hepatitis C virus infection. In Group 2, HCC showed larger mean tumour diameter (P 〈 0.001), poorer differentiation (P 〈 0.05) and more frequent macrovascular invasion (P 〈 0.05). Although more extended resections were performed in Group 2 (P 〈 0.001), there were no differences in blood transfusions, while post-operative complication rate was higher in Group 1 (P 〈 0.005). After 1992, in-hospital mortality was 2.9% in Group 1 and 1.1% in Group 2 (P = N.S.). The 3- and 5-year overall survival was 63.7% and 42.2% in Group 1, and 67.9% and 51% in Group 2 (P 〈 0.05). The 3- and 5-year disease-free survival was 49.3% and 27.8% in Group 1, and 58% and 45.6% in Group 2 (P 〈 0.005). Serum bilirubin level 〉 1.2 mg/dL, multiple nodules, micro and macrovascular invasion, diaphragm infiltration and blood transfusions independently affected survival in Group 1. Blood replacement was the only negative prognostic factor in Group 2. Independent risk factors for tumour recurrence were satellite nodules and resection performed before 1992 in Group 1, and age 〈 60 in Group 2.Conclusions : Despite a more aggressive behaviour, HCC without cirrhosis led to better overall and disease-free survival compared to HCC with cirrhosis after curative liver resection. Age and intra-operative blood transfusions are the only predictors of outcome in patients without cirrhosis. The impact of the latter on long-term survival in both our groups outlines the importance of surgical technique on the results of hepatectomies.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1573-2932
    Keywords: 234Th ; particle flux ; Ross Sea ; Antarctica ; organic C ; N ; Si ; Scavenging rates
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract The distribution of dissolved and particulate 234Th in the upper 200 m of the water column was obtained for three stations in the Ross Sea off Victoria Land and Terra Nova Bay. At site 24a, close to the retreating ice margin, all the sampled depths showed deficiencies in 234Th relative to the equilibrium with 238U. These are related to uptake of 234Th onto sinking particles. Residence times of 234Th in solution and of particulate 234Th were 130-247 days and 8.1-6.6 days, respectively. A high particle flux (1.23-5.03 g m-2 d-1) was calculated at this station. At the other two sites (11c and 15c), 234Th depth profiles are irregular, probably due to the release of dissolved 234Th by decomposing particles at certain depths, or to the contribution from lateral advection. Bulk mass fluxes measured by floating traps at stations 11c and 15c are very low (66-138 mg m-2 d-1). Also fluxes of organic carbon and nitrogen, and biogenic silica are reported for these two sites. The calculated fluxes are discussed with respect to methodologies and to the dynamics of the ice margin retreat.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1573-2932
    Keywords: 234Th ; particle flux ; Ross Sea ; Antarctica ; organic C, N, Si ; scavenging rates
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract The distribution of dissolved and particulate234Th in the upper 200 m of the water column was obtained for three stations in the Ross Sea off Victoria Land and Terra Nova Bay. At site 24a, close to the retreating ice margin, all the sampled depths showed deficiencies in234Th relative to the equilibrium with238U. These are related to uptake of234Th onto sinking particles. Residence times of234Th in solution and of particulate234Th were 130–247 days and 8.1–6.6 days, respectively. A high particle flux (1.23–5.03 g m−2 d−1) was calculated at this station. At the other two sites (11c and 15c),234Th depth profiles are irregular, probably due to the release of dissolved234Th by decomposing particles at certain depths, or to the contribution from lateral advection. Bulk mass fluxes measured by floating traps at stations 11c and 15c are very low (66–138 mg m−2 d−1). Also fluxes of organic carbon and nitrogen, and biogenic silica are reported for these two sites. The calculated fluxes are discussed with respect to methodologies and to the dynamics of the ice margin retreat.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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