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  • 1
    Electronic Resource
    Electronic Resource
    Fracture prevalence and bone mineral mass in osteoporosis measured with computed tomography and dual energy photon absorptiometry (1986)
    Springer
    Skeletal radiology 15 (1986), S. 191-197 
    Details
    ISSN: 1432-2161
    Keywords: Densitometry ; Bone mineral content ; Osteoporosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In 174 adults presenting with backache, bone densitometry was performed on the lumbar spine, both femoral necks, and one femoral shaft employing dual energy photon absorptiometry (DPA); in 112 of these, densitometry was under-taken on L4 using single energy quantitative computer assisted tomography (CT). Radiographs of the spine were obtained in all patients and those with known or suspected malignant disease were excluded. The subjects were divided into two groups according to the presence (n=128) or absence (n=44) of signs of vertebral collapse or compression. The predictive value of the densitometric results for the presence of vertebral fractures was calculated and used as an estimate of fracture risk. While CT showed somewhat higher predictive values than DPA of the spine or combinations of DPA results from spine and femoral necks, the difference was not significant. It is concluded that with both CT and DPA the probability of the presence or absence of fracture can be raised to 75–80% when the probability prior to the investigation is 50% and when the threshold values of the measurements are chosen so that their sensitivity and specificity are about equal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00354059
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  • 2
    Electronic Resource
    Electronic Resource
    Assessment of osteoporotic spine deformity (1990)
    Springer
    Skeletal radiology 19 (1990), S. 91-97 
    Details
    ISSN: 1432-2161
    Keywords: Osteoporosis ; Spine fracture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract For the objective assessment of the severity and progression of osteoporotic deformities of the spine, a mathematical model has been developed which permits evaluation of a single set of radiographs of the spine without reference to absolute values of vertebral height. The model was based on measurements of anterior, central and posterior heights of the vertebrae Th4 to L5 of 50 subjects, aged 20 to 50 years, without a history or radiologic signs of osteoporosis or other metabolic bone disease and without traumatic deformities. The model follows a simple sinusoidal function which describes the general form of the spine, adapted to the individual's height and build. A spine fracture index (SFI) is produced and the method allows calculation of the total number of vertebral deforming events (VDE), and vertebral deformation score (VDS) in an objective manner. The method has been used prospectively in 178 spine radiographs of 109 subjects (60 healthy early postmenopausal women and 49 with osteoporosis). Sensitivity and specificity of SFI in identifying osteoporotic patients were 94 and 88% respectively. In all 109 persons, densitometry of the spine was performed by dual photon absorptiometry at the same time. In the osteoporotic patients the examination was repeated once or twice during fluoride therapy for osteoporosis. The SFI and the total score of VDE and VDS correlated significantly with lumbar bone mineral content (r = -0.38 P < 0.001). The method offers the advantage of being objective, not dependent on projection errors, and adaptable to the shape of the individual spine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00197612
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Quantitative-histological comparison of bone biopsies taken from patients with osteoporosis, and primary and secondary hyperparathyroidism (1976)
    Springer
    Calcified tissue international 22 (1976), S. 404-406 
    Details
    ISSN: 1432-0827
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02064113
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Clinical use of a parathyroid hormone determination (1976)
    Springer
    Calcified tissue international 22 (1976), S. 412-414 
    Details
    ISSN: 1432-0827
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02064115
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    The value of local99mTc (Sn)-MDP bone to soft tissue uptake ratio in osteoporosis, before and during fluoride therapy (1990)
    Springer
    European journal of nuclear medicine 16 (1990), S. 157-160 
    Details
    ISSN: 1619-7089
    Keywords: Bone Scintigraphy ; Uptake ratio ; Osteoorosis ; Fluoride
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The reproducibility and diagnostic value of local bone to soft tissue uptake ratio of99mTc(Sn)-MDP as a bone tracer was examined in a prospective study in 35 patients who were under investigation and/or treatment for postmenopausal osteoporosis. The ratio of tracer uptake in the second lumbar vertebra (L2) and both femoral shafts was calculated from the number of counts in suitable regions of interest. Results obtained with settings and calculations in the routine practice were compared to the results obtained by revision of all raw data in one run by one person. The results were compared to the serum alkaline phosphatase activity (AP) and to local bone mineral mass as determined by dual photon absorptiometry (DPA). In 15 patients serial measurements during fluoride therapy were also compared to serum osteocalcin values and to bone histomorphomatric data. The precision error of the calculation of uptake ratios from raw counts (including selection of region of interest) was 13.9% for the femoral shaft and 14.7% for L2. The mean difference between left and right femoral shaft in individuals was not significant and its variance was smallP 〉 0.1). There was a weak but significant linear correlation between local uptake ratio in the spine and AP in the total material (r=0.328P 〈 0.01). However, changes in local uptake ratio during therapy with fluoride in 15 patients were too small to be of any value and did not correlate with changes in alkaline phosphatase or osteocalcin or trabecular surface covered with osteoblasts. We conclude therefore that local uptake ratio of bone seeking isotopes has no value in assessing general metabolic bone activity in osteoportic patients, for diagnostic purposes or in the follow up of their response to therapy, except for the detection of local untoward reactions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01146854
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  • 6
    Electronic Resource
    Electronic Resource
    Epidemiology of hip fractures in The Netherlands: Women compared with men (1992)
    Springer
    Osteoporosis international 2 (1992), S. 279-284 
    Details
    ISSN: 1433-2965
    Keywords: Age-adjusted ; Age-specific ; Hip fractures ; Incidence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In this retrospective study the epidemiology of hip fractures in The Netherlands was evaluated. The number of hip fractures over the period 1972–1987 was collected from the Dutch Centre for Health Care Information (Stichting Informatiecentrum voor de Gezondheidszorg, SIG). The demographic data were collected from the Dutch Centre for Statistics (Centraal bureau voor de Statistiek, CBS). The age-adjusted incidence of hip fractures for both women and men 50 years of age and over, increased linearly over the period 1972–1987. There was also a linear rise in the age-adjusted incidence of hip fractures in women and men 65 years of age and over, but the rise in incidence was equal in both sexes. After the age of 50 years women and men showed an equal proportional increase in the age-specific incidence of hip fractures by 5-year age groups. This proportional increase was independent of the calendar year studied during the period 1972–1987. The increase over time in the age-adjusted incidence of hip fractures in inhabitants 50 years of age and over is the result of changes that act well before the age of 50 years, because the proportional increase in the age-specific incidence of these fractures after the age of 50 years did not change over the period studied. The cohort analysis showed that the age-specific incidence of hip fractures in more recently born birth cohorts is higher than that in birth cohorts born long ago. This observation agrees with the other observations. However the cohort analysis also showed evidence that the increase in the age-specific incidence of hip fractures, with increasing age groups might be smaller in more recently born birth cohorts. Therefore the age-specific incidence of hip fractures in the oldest age group, i.e. in inhabitants 85 years of age and over, might become equal for all birth cohorts. It is concluded that preventive measures and various interventions should be started before the age of 50 years in both women and men.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01623183
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