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  • 1
    Electronic Resource
    Electronic Resource
    Marked individual variability in heart rate ‘normalization’ by ethanol (1978)
    Springer
    Psychopharmacology 58 (1978), S. 95-98 
    Details
    ISSN: 1432-2072
    Keywords: Ethanol ; Mice ; Humans ; Heart rate ; Response variability ; Normalization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In order to test Kissin's (1974) concept of ‘normalization’ by ethanol (deviant prealcohol parameter values becoming less deviant after alcohol) in nonalcoholics, data on unselected mice and nonalcoholic humans were analyzed. These data were on heart rates (HR) of 1055 HS mice and 24 young adults, measured before and after receiving a dose of ethanol (mice: 1.4g/kg, i.p.; humans: 1.3g/kg, oral). Both mice and humans, on the average, show marked ‘normalization’, initially low HR usually increasing after alcohol, and initially high HR usually decreasing. The correlation between (1) deviation in HR from the prealcohol mean and (2) change in HR after alcohol was-0.803 for mice and-0.538 for humans. There is very great individual variability, however, in the degree of this normalizing response, some individuals normalizing strongly and others not at all. Although first described in alcoholics, strong normalization by alcohol of several psychophysiological parameters is now known to occur in mice and seems likely to occur in some nonalcoholic humans. The possible relevance of these results to predisposition to alcoholism remains to be shown.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00426796
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  • 2
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    CAUCASIAN ADMIXTURE IN TWO OJIBWA INDIAN COMMUNITIES IN ONTARIO (1972)
    Baltimore : Periodicals Archive Online (PAO)
    Human Biology. 44:4 (1972:Dec.) 655 
    Details
    ISSN: 0018-7143
    Topics: Biology
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:5243-1972-044-04-000005
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  • 3
    Electronic Resource
    Electronic Resource
    Mechanism for heritability of intelligence (1984)
    [s.l.] : Nature Publishing Group
    Nature 311 (1984), S. 417-417 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR - I wish to suggest a partial answer to the important question of what mechanism in the central nervous system may account for the heritability of intelligence1. Although we are far from having a generally agreed definition of intelligence, let alone an understanding of the mechanism ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/311417b0
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  • 4
    Electronic Resource
    Electronic Resource
    An Association between ABO Blood Groups and Fertility in a Normal American Population (1959)
    [s.l.] : Nature Publishing Group
    Nature 184 (1959), S. 611-612 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE possibility of fertility differences associated with ABO blood group phenotype has been investigated in married couples in two populations1-2, using couples unselected with respect to their fertility. In 161 white American couples who had completed their families, fertility differences ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/184611a0
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  • 5
    Electronic Resource
    Electronic Resource
    Living in the past? (1982)
    [s.l.] : Nature Publishing Group
    Nature 298 (1982), S. 320-320 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR ? It would be unfortunate if the pungent style of S. Blinkhorn's review of The Mismeasures of Man by S. J. Gould, (Nature 8 April, p.506) should weaken the force of his criticism. Like Blinkhorn I think there is much to object to in this book and, for T. J. M. Schpf (Nature 13 May, p.98), I ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/298320d0
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  • 6
    Electronic Resource
    Electronic Resource
    Number of Gene Loci required for Accurate Estimation of Ancestral Population Proportions in Individual Human Hybrids (1973)
    [s.l.] : Nature Publishing Group
    Nature 244 (1973), S. 575-576 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] To make the argument as simple as possible and avoid intractable complexities (which we discuss later), I postulate an ideal estimation situation. Because real estimation will not be as favourable, the estimate from the ideal model of the number of loci will necessarily represent the minimum. We ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/244575a0
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  • 7
    Electronic Resource
    Electronic Resource
    Reply to the comments by Mayerová, Müller, Wiberg, Wolf, and Fraccaro Hum Genet 66:110–112 (1984)
    Springer
    Human genetics 〈Berlin〉 66 (1984), S. 113-114 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00286585
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  • 8
    Electronic Resource
    Electronic Resource
    Narrow-sense heritability estimates for nerve conduction velocity and residual latency in mice (1988)
    Springer
    Behavior genetics 18 (1988), S. 595-603 
    Details
    ISSN: 1573-3297
    Keywords: nerve conduction velocity ; residual latency ; mice ; humans ; heritability ; intelligence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract Conduction velocity (CV) and residual latency (RL; delay at the neuromuscular junction) were determined in the tail nerves of 1366 HS mice distributed in 230 families. The mean CV was 25.76 m/s, with a range from 17.44 to 34.62 m/s. The mean RL was .93 ms, with a range from .63 to 1.32 ms. Estimates of narrow-sense heritabilities (h n 2 ) were obtained by regressing midoffspring means on midparent means. Theh n 2 estimate for CV was .228±.053 (p〈.0001); that for RL was .069±.053 (p=.20). The CV estimate agrees with previous estimates from mice; reasons are given whyh n 2 in humans should be appreciably greater. Since human intelligence appears to be correlated with information processing speed, and brain CV should be a component of this speed, CV may have some important implications for intelligence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01082311
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  • 9
    Electronic Resource
    Electronic Resource
    Nerve conduction velocity in mice: A new method with results and analysis of variation (1983)
    Springer
    Behavior genetics 13 (1983), S. 257-265 
    Details
    ISSN: 1573-3297
    Keywords: mice ; nerve conduction velocity ; heritability ; anesthesia ; temperature control
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract A new method for measuring nerve conduction velocity (CV) in the tails of awake mice in a temperature-controlled environment is described and applied. Sixty male HS mice, with an average age of 65.6 days, had a mean (±SE) CV of 21.01±0.29 ms−1. Thirty-five male mice in four inbred strains (DBA/1J, C3H/HeJ, C57BL/6J, A/J), aged 60 to 66 days, had higher mean CVs. These inbred strains differ among themselves in mean CV. Repeated testing shows that CV is a stable trait over time, especially in genetically heterogeneous mice. Broad-sense heritability for CV probably exceeds 0.4, greater than previously reported.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01071871
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  • 10
    Electronic Resource
    Electronic Resource
    Between- and within-race variation in acute cardiovascular responses to alcohol: Evidence for genetic determination in normal males in three races (1986)
    Springer
    Behavior genetics 16 (1986), S. 585-598 
    Details
    ISSN: 1573-3297
    Keywords: alcohol ; heart rate ; blood pressure ; race ; genetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract Cardiovascular responses (changes in heart rate, systolic and diastolic blood pressure) of 103 normal young adult males (46 European, 30 Japanese, 27 Chinese) to a test drink of alcohol were analyzed. The two Oriental groups did not differ in their mean responses (measured as postdrink value minus baseline value). When these two groups were pooled as “Orientals,” they differed very significantly from Europeans in their responses. Each of the three groups showed marked between-individual variability in alcohol response for each cardiovascular parameter, in the absence of obvious environmental differences. Repeated-measures ANOVA on these and other data, plus a direct genetic study in mice of the heritability of alcohol-induced change in heart rate, indicates that the broad-sense heritability of such changes in humans is in the region 0.3 to 0.5.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01066285
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