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  • 1
    Electronic Resource
    Electronic Resource
    Effects of the pyrimidine-containing cytochrome P-450 inhibitor, fenarimol, on the formation of 20-OH ecdysone in flies (1991)
    Springer
    Cellular and molecular life sciences 47 (1991), S. 261-263 
    Details
    ISSN: 1420-9071
    Keywords: Calliphora vicina ; Neobellieria bullata ; fenarimol ; synthesis of 20-hydroxy ecdysone ; cytochrome P-450 inhibitor ; microsomal ecdysone 20-monooxygenase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The effect of fenarimol, a pyrimidine-containing cytochrome P-450 inhibitor, was tested in vitro on brain-ring gland complexes ofCalliphora vicina (Dipt., Calliphoridae), and on microsomes prepared from the fat body of 0-h wandering stage larvae ofNeobellieria bullata (Dipt., Sacrophagidae). Fenarimol had no influence on the formation of ecdysone, but it was an effective inhibitor of cytochrome P-450-dependent ecdysone 20-monooxygenase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01958154
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  • 2
    Electronic Resource
    Electronic Resource
    Immunocytochemical localisation of an FMRFamide-like peptide in the filarial nematodesDirofilaria immitis andBrugia pahangi (1992)
    Springer
    Parasitology research 78 (1992), S. 252-256 
    Details
    ISSN: 1432-1955
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Immunocytochemical techniques were used to detect FMRFamide-like immunoreactivity in adults of the filarial nematodesDirofilaria immitis andBrugia pahangi. An FMRFamide-like peptide was also located in third-and fourth-stage larvae ofd. immitis. Positive immunoreactivity was observed in all parasites examined, irrespective of developmental stage. The major areas of positive immunoreactivity were located in the anterior nerve ring, lateral/dorso-ventral nerves, cephalic papillary ganglia and lateral ganglia. No staining was seen in the intestine or gonads of any parasite. These results indicate that filarial worms possess a peptidergic component in their nervous system. The possible role of an FMRFamide-like peptide in the control of certain physiological events is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00931735
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  • 3
    Electronic Resource
    Electronic Resource
    The effect of ecdysteroids on the microfilarial production ofBrugia pahangi and the control of meiotic reinitiation in the oocytes ofDirofilaria immitis (1991)
    Springer
    Parasitology research 77 (1991), S. 65-71 
    Details
    ISSN: 1432-1955
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The effects of the ecdysteroids ecdysone and 20-hydroxyecdysone on microfilarial release inBrugia pahangi and on meiotic reinitiation in the oocytes ofDirofilaria immitis were studied. Ecdysone was found to stimulate microfilarial release at 2×10−6 M, but this effect was reduced at higher and lower concentrations. 20-Hydroxyecdysone was found to have no such effect. InD. immitis, ecdysone at 10−5 M was also found to overcome the period of meiotic arrest that occurs during the pachytene stage of prophase 1. This effect was reduced when 10−6 M ecdysone was used. These results help support the theory that the ecdysteroids play a hormonal role in filarial worms similar to that found in insects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00934388
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  • 4
    Electronic Resource
    Electronic Resource
    Evidence for the release of 20-hydroxyecdysone 25-glucoside by adult femaleParascaris equorum (Nematoda) in vitro (1991)
    Springer
    Parasitology research 77 (1991), S. 271-272 
    Details
    ISSN: 1432-1955
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00930872
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  • 5
    Electronic Resource
    Electronic Resource
    Metabolism of [3H]-ecdysone in Schistocerca gregaria; formation of ecdysteroid acids together with free and phosphorylated ecdysteroid acetates (1984)
    New York, NY [u.a.] : Wiley-Blackwell
    Archives of Insect Biochemistry and Physiology 1 (1984), S. 385-407 
    Details
    ISSN: 0739-4462
    Keywords: ecdysone metabolism ; Schistocerca ; HPLC ; ecdysteroid acids ; acetates ; phosphates ; Chemistry ; Food Science, Agricultural, Medicinal and Pharmaceutical Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: The metabolism of [3H]-ecdysone has been investigated at times of low and high endogenous ecdysteroid tit re, in early and late fifth-instar Schistocerca gregaria larvae, respectively. Ecdysone-3-acetate, 20-hydroxyecdysone, and 20,26-dihydroxyecdysone were identified as metabolites in both the free form and as polar conjugates. Comparison of the intact polar conjugates of the ecdysteroid acetates on two HPLC systems with the corresponding authentic compounds indicated that they were 3-acetylecdysone-2-phosphate and 3-acetyl-20-hydroxyecdysone-2-phosphate. Other major polar metabolites were identified as ecdysonoic acid and 20-hydroxyecdysonoic acid. Ecdysone metabolism in fifth-instar S. gregaria is apparently an age-dependent process. Early in the instar, excretion of both free and conjugated ecdysteroids, as well as ecdysteroid 26-acids, occurs. At this stage the level of ecdysteroid acetates in the conjugated (phosphate) form is high, in contrast to the free ecdysteroids, where ecdysone predominates. When the endogenous hormone titre is high, the formation of ecdysteroid acetates is less, the major excreted matabolites at that stage being conjugated 20-hydroxyecdysone together with ecdysteroid-26-acids, but little free ecdysteroids. Acetylation of ecdysone occurs primarily in the gastric caecae. Ecdysone-3-acetate (mainly as polar conjugate) is also a major product of ingested ecdysone in early fifth-instar Locusta migratoria.
    Additional Material: 12 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/arch.940010409
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  • 6
    Electronic Resource
    Electronic Resource
    Absence of phytosterol dealkylation and identification of the major ecdysteroid as makisterone A in Dysdercus fasciatus (Heteroptera, Pyrrhocoridae) (1983)
    New York, NY [u.a.] : Wiley-Blackwell
    Archives of Insect Biochemistry and Physiology 1 (1983), S. 105-120 
    Details
    ISSN: 0739-4462
    Keywords: phytosterol dealkylation ; ecdysteroids ; makisterone A ; Heteroptera ; Dysdercus ; gas-liquid chromatography/mass spectrometry ; cotton stainer bug ; ecdysone ; 20-hydroxyecdysone ; Chemistry ; Food Science, Agricultural, Medicinal and Pharmaceutical Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: The absence of phytosterol dealkylation in the cotton stainer bug, Dysdercus fasciatus, has been established and the major ecdysteroid in the fifth-stage larvae identified. The demonstration that the free and esterified sterols in D fasciatus consisted of 95-96% sitosterol and 4-5% campesterol, a similar composition to the cottonseed diet, together with the lack of conversion of [14C]sitosterol into cholesterol, establishes that phytosterol dealkylation does not occur in this insect species. The ecdysteroid titer determined by radioimmunoassay in the fifth instar of D fasciatus shows a distinct peak at day 6, the instar lasting for 7 days. Makisterone A was purified by HPLC from insects at a time of high ecdysteroid titer and identified as a major component by both fast atom bombardment and electron impact mass spectrometry. Gas-liquid chromatography/mass spectrometry (selected ion monitoring) confirmed the occurrence of makisterone A and revealed the presence of two unidentified compounds. One of these occurs in a similar amount to makisterone A and may be 26-hydroxymakisterone A, whereas only a minute amount of the other compound, which may be 20-deoxymakisterone A, was present; further identification of the latter compounds is necessary. C27 ecdysteroids (eg, ecdysone and 20-hydroxyecdysone) and C29 ecdysteroids (eg, podecdysone A) were undetectable. The specificity of the enzymes of ecdysteroid biosynthesis is discussed.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/arch.940010111
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