ISSN:
1432-069X
Keywords:
Topical treatment
;
13-cis-Retinoic acid
;
Darier's disease
;
Ichthyosis
;
Cytokeratins
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract In a bilaterally paired double-blind comparison study, a cream containing 0.1% 13-cis-retinoic acid (13-cis-RA) and cream base only were applied over 4 weeks in seven patients with non-erythrodermic lamellar ichthyosis (NELI), two patients with Darier's disease and one patient with autosomal dominant ichthyosis vulgaris (ADIV). In two patients with NELI and two patients with Darier's disease a half-side effect was observed in favour of the side treated with 13-cis-RA. In three patients an induction of cytokeratin-4, and in one of these patients expression of cytokeratin-13, were observed after therapy. Topical 13-cis-RA-appears to be a promising approach in the treatment of disorders of keratinization. The selective modulation of the cytokeratin pattern may provide an immunohistochemical tool to investigate the mode of action of retinoids.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00372013
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