Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    ISSN: 1520-6041
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    facet.materialart.
    Unknown
    Berlin : Periodicals Archive Online (PAO)
    Orientalistische Literaturzeitung. 40 (1937) 379 
    ISSN: 0030-5383
    Topics: Linguistics and Literary Studies , Ethnic Sciences , History
    Notes: Besprechungen
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    ISSN: 0031-8914
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    facet.materialart.
    Unknown
    Boston : Periodicals Archive Online (PAO)
    Business History Review. 52:1 (1978:Spring) 113 
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    facet.materialart.
    Unknown
    Boston : Periodicals Archive Online (PAO)
    Business History Review. 53:4 (1979:Winter) 580 
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 268 (1980), S. 129-140 
    ISSN: 1432-069X
    Keywords: Epidermis ; Enrichment ; Binding ; 8-MOP ; 5-MOP ; Epidermis ; Anreicherung ; Bindung ; 8-MOP ; 5-MOP
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In dieser Arbeit wird eine einfache Methode zur Messung der Anreicherung von verschiedenen Substanzen im epidermalen Gewebe beschrieben. Die Gewebeprobe (2–10 mg) wird in einer physiologischen Lösung mit der radioaktivmarkierten Substanz bis zum Gleichgewicht inkubiert (12–36 h). Die Radioaktivität der Lösung wird vor und nach der Inkubation gemenssen. Die Differenz zwischen den beiden Messungen wird als Maß für die Anreicherung der Substanz im Gewebe genommen. Unter Berücksichtigung der spezifischen dichte der Epidermis, die bei Vorversuchen an isolierter menschlicher Epidermis als 1,2 g/cm3 bestimmt wurde, wird die Konzentration der Substanz in der Epidermis berechnet. Die nach dieser indirekten Methode berechnete Konzentration stimmt mit der tatsächlich gefundenen Konzentration der Substanz in der Epidermis nach alkalischer Hydrolyse überein. Die Anreicherung im epidermalen Gewebe wurde an alpha-Östradiol, Thiopyronin, 5-MOP, 8-MOP und Theophyllin untersucht. Außer bei Theophyllin wurde bei allen anderen untersuchten Substanzen eine 10–500 fach höhere Konzentration im Gewebe gefunden. Die Analyse der Ergebnisse, um eine reversible Bindung von einer Verteilung der Substanz zwischen den Zellkomponenten zu unterscheiden, zeigte sich im Falle von Thiopyronin und 8-MOP eine reversible Bindung mit einer Dissoziationskostanten von 10-7 und 10-5, hinsichtlich von 5-MOP und alpha-Östradiol eine partielle Verteilung. Diese Methode kann als eine schnelle Screening-Methode oder als eine quantitative Analyse zur Charkterisierung der Anreicherung von Substanzen im Gewebe angewendet werden.
    Notes: Summary A rapid and simple method is described for measuring the enrichment of small molecules in epidermal tissue. To measure such an enrichment, a small tissue sample (2–10 mg) is allowed to equilibrate with a buffered solution of a labelled substance for periods of 12–36 h. The concentration of the radioactive molecule in the tissue is measured as a decrease of radioactivity in the solution. Concentration measurements in the tissue itself can be performed, but are not required to detect enrichment in the tissue or to assess its magnitude. The specific density of appendage free human epidermis has been determined and was found to be 1.20 g/cm3. Using this value, tissue weight can be translated into volume and concentration changes in the solution can be recalculated to yield the concentration of the substance in the tissue itself. Close agreement was found between the calculated tissue concentration and the values actually measured, following digestion of the epidermis with NaOH and measuring the activity in the tissue digest. The enrichment of five substances in human epidermis was measured: α-estradiol, thiopyronine, 8-methoxypsoralen (8-MOP), 5-methoxypsoralen (5-MOP), and theophylline. Of these substances, the first four are concentrated by human epidermis and the concentrations reached within the tissue are 10–500 times higher than the concentration of the same substance in the surrounding buffer. The enrichment data has been analysed in an attempt to distinguish between reversible affinity binding to specific tissue sites and partitioning of the substances between buffer and tissue components (lipids, membranes, etc.). In the case of thiopyronine and 8-MOP, reversible binding is indicated with dissociation constants of 10-7 M and 10-5 M, respectively, while partitioning distribution could account for the behavior of 5-MOP and α-estradiol. The method can be used either as a rapid screening method or as a quantitative analysis for the characterization of tissue enrichment with specific drugs.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Abdominal imaging 21 (1996), S. 105-116 
    ISSN: 1432-0509
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Abdominal imaging 22 (1997), S. 91 -95 
    ISSN: 1432-0509
    Keywords: Key words: Pelvic organs, MR—Pelvis, MR—Pelvic organ, neoplasms—Fistula, colonic—Fistula, enterovesical—Fistula, enterocutaneous.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Background: This multi-institutional study examines appearances of pelvic fistulas on magnetic resonance (MR) images. Methods: MR images of 46 patients with documented fistulas from five teaching hospitals were retrospectively reviewed. All patients underwent T1-weighted (T1WI), T2-weighted (T2WI), and intravenous gadolinium chelate-enhanced T1-weighted (Gd-T1WI) images. Imaging sequences were separately and then collectively reviewed. The following determinations were made: fistula detection, fistula morphology and signal intensity, and the presence of associated abnormalities. Fistulas were classified into two categories: (1) fistulas that communicate with the bladder and (2) fistulas that do not communicate with the bladder. Fistulas within these two groups were subclassified further. The presence of fistulas was documented by surgery (five patients), endoscopy (six patients), fistulogram (20 patients), or physical exam (15 patients). Results: Among the 46 patients, 53 fistulas were documented by means other than MR. Overall T1WI, T2W1 and Gd-T1WI images demonstrated 23, 31, and 39 of 53 fistulas, respectively. Gd-T1W1 detected significantly more fistulas than T1W1 (p 〈 0.05). Bladder fistulas were better shown on Gd-T1WI (8/15 fistulas) than on T1WI and T2WI (2/15 and 3/15) (p 〈 0.05). Nonbladder fistulas were demonstrated by T1WI, T2WI, and Gd-T1WI images in 21, 28, and 31 of 38 fistulas, respectively. Among all fistulas, perianal fistulas (a subcategory of nonbladder fistula) had the highest detection by T1WI, T2WI, and Gd-T1WI in 19, 20 and 22 of 23 fistulas, respectively. On T1WI, 19 of 23 detected fistulas were low in signal intensity. On T2WI, 28 of 39 detected fistulas were high in signal intensity. On Gd-T1WI images, 29 of 40 fistulas were low in signal intensity, with enhanced tract wall. Conclusion: Bladder fistulas were best shown on Gd-T1WI, which was significantly greater than on T1WI or T2WI. Nonbladder fistulas were comparably shown by all techniques, with all performing modestly well. Perianal fistulas were shown equally well by all MR sequences and were the fistulas demonstrated with the highest sensitivity on MR images.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Abdominal imaging 22 (1997), S. 277 -280 
    ISSN: 1432-0509
    Keywords: Key words: Computed tomography (CT)—Contrast media—Liver—Blood supply—Portal vein—Flow dynamics.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Background: The purpose of this study was to evaluate the effect of portal flow augmentation on hepatic computed tomographic (CT) enhancement. Methods: Thirteen patients undergoing follow-up CT of the liver within 6 months of initial study ingested 470 mL of Ensure® 30 min before the second examination. Contrast medium injection and scanning parameters were identical for both studies. Results: The time to peak and the maximum and mean liver enhancements were 68 s, 56 HU, and 46 HU, respectively, for the examinations without Ensure® and 68 s, 53 HU, and 44 HU for the examinations with Ensure®. No significant difference was found between the two groups when mean liver enhancement was calculated over 3-s time intervals. Conclusion: Portal venous flow augmentation induced by a meal had no effect on liver enhancement.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 10
    ISSN: 1432-0509
    Keywords: Key words: Magnetic resonance (MR)—Contrast enhancement—Contrast media—Experimental studies—Gadolinium.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: To quantify enhancement parameters of the upper abdominal organs over time during magnetic resonance (MR) examinations and to evaluate the effect of a dose reduction of contrast medium on these parameters. Methods: Ten volunteers underwent two separate dynamic enhanced MR examinations with 0.1 and 0.075 mmol/kg of contrast medium, respectively. Breath-hold gradient-echo T1-weighted images were acquired every second for 118 s followed by delayed images. The percentages of enhancement, the time to maximum enhancement, and the area under the time-versus-enhancement curve were calculated for each organ. Results: The mean times to maximum percentage of enhancement were less than 25 s for the pancreas, kidneys, and spleen and 50 s for the liver. The mean values of maximum percentage of enhancement for the standard/reduced doses were 72%/62% (pancreas), 165%/155% (kidneys), 114%/87% (spleen), and 67%/53% (liver). This difference was significant when liver enhancement was considered (p= 0.02). In addition, when the areas under the time-versus-enhancement curves were compared, the difference between the standard dose and reduced dose was significant for all organs tested (p 〈 0.05). Conclusions: Dynamic scanning of the upper abdomen should start early after contrast injection. Injection parameters should be standardized to capture arterial and venous enhancements in liver examinations. A 25% dose reduction did not significantly affect peak enhancement (except for the liver) but did significantly reduce overall enhancement.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...