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  • 1
    Electronic Resource
    Electronic Resource
    Effect of CpG methylation on gene expression in transfected plant protoplasts
    Amsterdam : Elsevier
    Gene 94 (1990), S. 189-193 
    Details
    ISSN: 0378-1119
    Keywords: CpNpG methylation ; DNA methylation ; M . HpaII/HhaI methylation ; M . SssI methylation ; microinjected Xenopus oocytes ; plant cell transfection ; plant promoter regulation
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0378-1119(90)90386-6
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Mode of action of the Spiroplasma CpG methylase M.SssI
    Amsterdam : Elsevier
    FEBS Letters 313 (1992), S. 243-247 
    Details
    ISSN: 0014-5793
    Keywords: M.Hhal methylase ; M.Hpall methylase ; M.SssI methylase ; Processive methylation
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(92)81201-V
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Monogenic determinants of familial Alzheimer's disease: presenilin-2 mutations (1998)
    Springer
    Cellular and molecular life sciences 54 (1998), S. 910-919 
    Details
    ISSN: 1420-9071
    Keywords: Key words. Alzheimer's disease; presenilin-2; presenilin-1; APP; Aβ; sel-12; apoptosis.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. Presenilin-2 (PS2) is one of three genes [amyloid precursor protein (APP), presenilin-1 (PS1) and PS2] shown to cause familial Alzheimer's disease (FAD), and is highly homologous to PS1. Currently demonstrated functions of PS2 include interactions with APP and Aβ, and participation in apoptotic pathways. PS2 FAD mutations influence APP processing in a manner predicted to promote amyloid formation and also enhance the proapoptotic effect of wild-type PS2. Other possible functions of PS2 are related to its homology to Notch pathway genes in Caenorhabditis elegans, suggesting it may have a developmental role. PS2-associated AD is the most reminiscent of the sporadic form of the disease in terms of older age of onset and longer disease duration. Since PS2 mutations are incompletely penetrant and age of onset in carriers is highly variable (40 – 88 years), elucidation of PS2 mechanisms may reveal factors which modify AD and are therapeutically relevant to sporadic AD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000180050220
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Isolation and characterization of the full-length 3′ untranslated region of the human von Hippel-Lindau tumor suppressor gene (1996)
    Springer
    Human genetics 〈Berlin〉 98 (1996), S. 666-671 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract We have isolated the 3′ untranslated region (3′UTR) of the human von Hippel-Lindau (VHL) tumor suppressor gene from a P1 phage containing the entire VHL genomic sequence. Several putative noncanonical (ATTAAA) poly(A) signals were identified, and the functional significance of these signals was examined by preparing VHL mammalian expression constructs with this DNA fragment and the previously isolated partial cDNA. Northern blot analysis from transfected renal carcinoma cells showed that both the endogenous and transgene VHL transcripts were the same length. Use of VHL transgene deletion mutants indicated that an ATTAAA sequence located between nucleotide (nt) +4237 and nt +4379 most likely serves as an active poly(A) signal in renal carcinoma cells, yielding a 3.6-kb 3′UTR. This work indicates that, together with the 5′UTR and the coding region, these sequences comprise the full-length human VHL cDNA. Sequence analysis revealed a 300- to 600-bp region conserved in human, murine, and rat VHL UTRs. In addition, the human 3′UTR was extremely rich in Alu repetitive elements.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004390050281
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    Paper (German National Licenses)
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