Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Potent carcinogenicity of nitrosodiethanolamine in rats (1980)
    [s.l.] : Nature Publishing Group
    Nature 288 (1980), S. 589-590 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Sixty male and sixty female Fischer 344 rats of the colony of the Frederick Cancer Research Center, bred and raised in SPF conditions, were housed in plastic cages with wire-mesh bottoms (five rats per cage). The animals were 6-7 weeks old at the beginning of the experiment, and were randomized ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/288589a0
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Protection by methylcholanthrene against hepatic carcinogenesis in rats ingesting N-4-(4′-fluorobiphenyl) acetamide (1976)
    Springer
    Cellular and molecular life sciences 32 (1976), S. 217-218 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Methylcholanthrene protected against the development of carcinomas of the liver in Fischer rats ingesting N-4-(4′-fluorobiphenyl)acetamide.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01937774
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Decreased incidence of renal cell carcinoma in rats with one kidney ingesting N-4-(4′-fluorobiphenyl) acetamide (1976)
    Springer
    Cellular and molecular life sciences 32 (1976), S. 218-219 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Buffalo strain male rats, 12 weeks of age, ingesting 0.04% N-4-(4′-fluorobiphenyl)acetamide in a semisynthetic diet with both kidneys intact were more susceptible to the development of hyperplasia and carcinomas of the kidney than were rats with a uninephrectomy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01937775
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Thyroiditis in Buffalo strain rats ingesting 7,12-dimethylbenz(a)anthracene (1969)
    Springer
    Cellular and molecular life sciences 25 (1969), S. 753-753 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Bei männlichen und weiblichen Ratten des Buffalo-Stammes trat nach Verabreichung von 7,12-Dimethylbenzanthracen eine Thyroiditis auf.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01897607
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Atrial thrombosis involving the heart of F-344 rats ingesting quinacrine hydrochloride (1984)
    Springer
    Archives of toxicology 56 (1984), S. 38-42 
    Details
    ISSN: 1432-0738
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Quinacrine hydrochloride is toxic for the heart of F-344 rats. Rats treated with 500 ppm quinacrine hydrochloride in the diet all developed a high incidence of left atrial thrombosis. The lesion was associated with cardiac hypertrophy and dilatation and focal myocardial degeneration. Rats died from cardiac hypertrophy with severe acute and chronic congestion of the lungs, liver, and other organs. Seventy percent of rats given 250 ppm quinacrine hydrochloride and 1,000 ppm sodium nitrite simultaneously in the diet had thrombosis of the atria of the heart, while untreated control rats in this laboratory did not have atrial thrombosis. Sodium nitrite in combination with quinacrine hydrochloride appeared to have no additional effect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00316350
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Interstitial cell carcinomas of the testis in Balb/C male mice ingesting methoxychlor (1979)
    Springer
    Journal of cancer research and clinical oncology 93 (1979), S. 173-179 
    Details
    ISSN: 1432-1335
    Keywords: Methoxychlor ; Testicular carcinomas ; Balb/c mice ; Interstitial cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Balb/c and C3H strains male and female mice ingested 750 ppm methoxychlor or 100 ppm DDT in the diet for 2 years. Balb/c strain male mice ingesting methoxychlor developed a highly significant incidence of interstitial cell carcinomas of the testis. Balb/c strain male mice ingesting DDT and C3H strain male mice receiving methoxychlor or DDT did not have testicular tumors. The carcinomas of the testis varied from well-differentiated to poorly differentiated and undifferentiated and were capable of metastasis. Carcinomas of the testis have been described in Balb/c strain male mice, but not C3H, given estrogens. The carcinogenicity for testis of Balb/c strain male mice is most likely related to the estrogenic activity of methoxychlor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00406575
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Carcinogenesis in F-344 rats by nitrosobis(2-oxopropyl)amine and related compounds administered in drinking water (1984)
    Springer
    Journal of cancer research and clinical oncology 107 (1984), S. 178-182 
    Details
    ISSN: 1432-1335
    Keywords: Carcinogenesis ; F-344 Rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Three asymmetric nitrosamines related to nitrosobis-(2-oxopropyl)-amine (BOP) were given to female F 344 rats in drinking water to assess the significance of other alkyl groups on the carcinogenic expression by the 2-oxopropyl group. Nitroso-oxopropylethanolamine (OPE) was weakly carcinogenic, leading to little life-shortening and to induction of tumors (most of them liver neoplasms) in less than half of the treated animals. BOP under these conditions induced a high incidence of hepatocellular carcinomas and hemangiosarcomas of the liver together with lung adenomas in most animals. At the same dose rate nitrosohydroxypropyl-oxopropylamine (HPOP) induced hepatocellular carcinomas, lung carcinomas, and carcinomas of the esophagus with a high incidence; life-shortening was greater with HPOP than with BOP. At a higher dose rate HPOP again induced a high incidence of esophageal carcinomas, and of liver neoplasms, but more animals had hemangiosarcomas than hepatocellular carcinomas. Nitrosodihydroxypropyl-oxopropylamine (DHPOP) increased the mortality rate due to tumors by much more than the other three compounds, but induced mainly tumors of the upper gastrointestinal tract and no neoplasms in the liver. These results do not support the concept that BOP acts through reduction to HPOP, but suggest rather that the nature of the substituents other than 2-oxopropyl in the analogs of BOP has a profound influence on the potency and organ-specificity of the carcinogen. It is probable that pharmacokinetics and the specificity of activation of the particular molecular structures play an important role.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01032604
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Increased incidence of carcinoma of the breast in Buffalo strain rats with one kidney ingesting N-4-(4′-fluorobiphenyl)acetamide (1976)
    Springer
    Journal of cancer research and clinical oncology 87 (1976), S. 173-179 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The role of the kidney in carcinogenesis of the breast was studied in inbred Buffalo strain female rats ingesting 0.04% N-4-(4′-fluorobiphenyl) acetamide. The experimental groups consisted of intact female rats 5 weeks of age with both kidneys intact and female rats with a uninephrectomy. The incidence of carcinomas of the breast and the number of rats with multiple carcinomas, poorly and undifferentiated carcinomas was greater in rats with a uninephrectomy. N-4-(4′-fluorobiphenyl)acetamide and its active metabolites apparently were not excreted as rapidly in the rats with one kidney as in the animals with both kidneys intact. The metabolites were then returned to the breast and/or other organs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00284374
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...