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  • 1
    Electronic Resource
    Electronic Resource
    Ecdysone and the onion (1992)
    [s.l.] : Nature Publishing Group
    Nature 357 (1992), S. 539-539 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The axiom that more than half of the secret of finding something is knowing where to look was well illustrated by two meetings Molecular Biology of Ecdysone Response Philadelphia, 11 March 1992. Tenth Ecdysone Workshop, University of Liverpool, 6-9 April, 1992. devoted to the molecular analysis ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/357539a0
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  • 2
    Electronic Resource
    Electronic Resource
    Sequential gene activation by ecdysteroids in polytene chromosomes ofDrosophila melanogaster (1982)
    Springer
    Development genes and evolution 191 (1982), S. 103-111 
    Details
    ISSN: 1432-041X
    Keywords: Drosophila ; Polytene Chromosomes ; Ecdysteroids ; Fat Body
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Changes in polytene chromosome 3 L puffing patterns in the fat body ofDrosophila melanogaster larvae and prepupae are compared to those in the salivary gland. While some general features are common to the two tissues, there are differences which reflect their different developmental roles. In vitro experiments with fat body chromosomes show that they have a distinct response to ecdysteroids which is different from that of salivary gland chromosomes, and which does not,in this culture system, reproduce the changes observed in normal development. In short term culture experiments, the fat body chromosomes appear more sensitive to ecdysteroids than the salivary gland chromosomes and, although 20-OH ecdysone is more active than ecdysone in these assays, the possibility is not excluded that ecdysone has a role in normal development as it appears to alter gene activity at physiological levels in these cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00848447
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  • 3
    Electronic Resource
    Electronic Resource
    The polytene chromosomes in the fat body nuclei ofDrosophila melanogaster (1980)
    Springer
    Chromosoma 79 (1980), S. 241-250 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract A photo-map of the polytene chromosomes of fat body nuclei from third instar larvae ofDrosophila melanogaster has been constructed and keyed to the revised salivary gland maps of Bridges (1938), Bridges and Bridges (1939) and Bridges (1941a, b, 1942). Apparent variations in banding pattern are discussed in the light of current studies on polytene chromosome structure and function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01175189
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  • 4
    Electronic Resource
    Electronic Resource
    GEBF-I in Drosophila species and hybrids: The co-evolution of an enhancer and its cognate factor (1992)
    Springer
    Molecular genetics and genomics 235 (1992), S. 104-112 
    Details
    ISSN: 1617-4623
    Keywords: Drosophila species ; Enhancer binding factor ; Gel retardation ; Hybrid larvae ; Glue genes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The activation of the Drosophila melanogaster salivary gland secretion protein gene Sgs-3 is marked by important changes in chromatin structure in the distal regulatory region at − 600 by from the Sgs-3 start site. A stage- and tissue-specific glue enhancer binding factor, GEBF-I, binds in vitro to sequences from this region. Previous studies have revealed considerable variation in the DNA sequences of comparable regions in the related Drosophila species, D. simulans, D. erecta and D. yakuba. We detected GEBF-I-like proteins in these species, which appear to evolve as rapidly as the corresponding DNA sequences, and studied in detail the binding characteristics of the GEBF-I proteins of the two most closely related species, D. melanogaster and D. simulans. In crosses between these species, certain strains produce hybrid larvae which, unexpectedly, synthesised a single intermediate form of the protein. This suggests that the factor is subject to species-specific post-transcriptional modifications. In these hybrid larvae, which carry one D. melanogaster and one D. simulans Sgs-3 gene, the hybrid GEBF-I protein appears equally effective in the induction of both target genes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00286187
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  • 5
    Electronic Resource
    Electronic Resource
    Allelic variation at the nucleotide level in Drosophila glue genes (1985)
    Springer
    Molecular genetics and genomics 201 (1985), S. 265-268 
    Details
    ISSN: 1617-4623
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary We have sequenced a 4.7 kb genomic fragment from the chromosomal region 68C of the Drosophila melanogaster wild-type strain Formosa which contains the salivary gland secretion protein genes sgs3 and sgs7. A comparison of this sequence with that from the same region of Oregon R (Garfinkel et al. 1983) shows that the major difference in this segment is a 300 bp region, corresponding to 20 of the 15 bp tandemly repeated units which compose the central coding region of sgs3 Oregon, which is absent in the Formosa strain. The order of the remaining repeated units, common to the two strains, suggests that this region is relatively stable and does not undergo frequent rearrangements or mutations. The 5′ and 3′ flanking sequences of the transcribed regions, which represent ca. seventy percent of our sequencing data, appear to be as strongly conserved as the transcribed sequences themselves. In the course of in vitro manipulations of the Formosa sequence, we have isolated two spontaneous deletions of repeated units in the coding region of sgs3 and discuss possible mechanisms leading to variation in sgs3 alleles.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00425669
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  • 6
    Electronic Resource
    Electronic Resource
    Regulatory elements and interactions in the Drosophila 68C glue gene cluster (1989)
    Chichester [u.a.] : Wiley-Blackwell
    Developmental Genetics 10 (1989), S. 189-197 
    Details
    ISSN: 0192-253X
    Keywords: Drosophila ; transformation ; Glue gene ; Gene cluster ; Gene regulation ; Sgs-3 ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: We reviewed studies on the developmental regulation of the 68C glue gene cluster of Drosophila melanogaster. Extensive transformation analyses of Sgs-3 have shown that four regions necessary for normal expression can be distinguished. The first ( + 10 to -50) contains the transcription start site and TATA motif. This region can be replaced functionally by corresponding sequences from the hsp70 gene, but it is sensitive to point mutations in the TATA sequence. The second region (-50 to -98) contains more than one upstream sequence that, in combination with the other elements, leads to stage and tissue-specific expression. The third region (centered at -600) contains an element that enhances transcript levels some 20-fold. The final region (between -1.65 and -2.35 kb) contains elements having modest (twofold to threefold) effects on expression, one of which is contained in the coding sequences of Sgs-7, a second member of the cluster.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/dvg.1020100308
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  • 7
    Electronic Resource
    Electronic Resource
    Into the lair of the gene (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Archives of Insect Biochemistry and Physiology 3 (1986), S. 143-155 
    Details
    ISSN: 0739-4462
    Keywords: Drosophila ; P elements ; regulatory sequences ; polytene chromosomes ; Chemistry ; Food Science, Agricultural, Medicinal and Pharmaceutical Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: A new picture of gene and chromosome structure is emerging in Drosophila that differs considerably from that largely derived from polytene chromosome banding patterns and saturation mutagenesis. In particular, gene transfer has enabled us to more clearly limit the functional unit of a number of genes. Gene regulation may be studied at the molecular level with such techniques. The possible complexity of regulatory elements that may pose problems in their analysis is discussed.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/arch.940030715
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