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  • 1
    Electronic Resource
    Electronic Resource
    Rating Child Psychiatric Caseness From Detailed Case Histories (1996)
    Oxford, UK : Blackwell Publishing Ltd
    The @journal of child psychology and psychiatry 37 (1996), S. 0 
    Details
    ISSN: 1469-7610
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: Novel operationalized criteria were used to rate detailed psychiatric case histories on 151 schoolchildren with hemiplegia. Ratings of psychiatric caseness or non-caseness were reliable and valid; the method may be widely applicable. Caseness was defined both narrowly (in terms of social incapacity for the child) and broadly (in terms of disruption lo others and distress too). Both definitions could be applied reliably lo children of normal intelligence but broadly defined caseness was more reliable lor children with low intelligence. Barely half of the psychiatric cases met operatinnalized criteria for one or more DSM-IV or ICD-10 diagnosis. The others mostly had partial or mixed syndromes that could, with clinical judgement, be assigned lo ‘not otherwise specified’ diagnoses. Even with clinical judgement, however, a substantial minority of children with low intelligence had clinically significant but undiagnosable abnormalities in social relatedness,
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1469-7610.1996.tb01418.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The Development and Well-Being Assessment: Description and Initial Validation of an Integrated Assessment of Child and Adolescent Psychopathology (2000)
    Oxford, UK : Blackwell Publishing Ltd.
    The @journal of child psychology and psychiatry 41 (2000), S. 0 
    Details
    ISSN: 1469-7610
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: The Development and Well-Being Assessment (DAWBA) is a novel package of questionnaires, interviews, and rating techniques designed to generate ICD-10 and DSM-IV psychiatric diagnoses on 5-ldyear-olds. Nonclinical interviewers administer a structured interview to parents about psychiatric symptoms and resultant impact. When definite symptoms are identified by the structured questions, interviewers use open-ended questions and supplementary prompts to get parents to describe the problems in their own words. These descriptions are transcribed verbatim by the interviewers but are not rated by them. A similar interview is administered to 1 l-16-year-olds. Teachers complete a brief questionnaire covering the main conduct, emotional, and hyperactivity symptoms and any resultant impairment. The different sorts of information are brought together by a computer program that also predicts likely diagnoses. These computer-generated summary sheets and diagnoses form a convenient starting point for experienced clinical raters, who decide whether to accept or overturn the computer diagnosis (or lack of diagnosis) in the light of their review of all the data, including transcripts. In the present study, the DAWBA was administered to community (N= 491) and clinic (N= 39) samples. There was excellent discrimination between community and clinic samples in rates of diagnosed disorder. Within the community sample, subjects with and without diagnosed disorders differed markedly in external characteristics and prognosis. In the clinic sample, there was substantial agreement between DAWBA and case note diagnoses, though the DAWBA diagnosed more comorbid disorders. The use of screening questions and skip rules greatly reduced interview length by allowing many sections to be omitted with very little loss of positive information. Overall, the DAWBA successfully combined the cheapness and simplicity of respondent-based measures with the clinical persuasiveness of investigator-based diagnoses. The DAWBA has considerable potential as an epidemiological measure, and may prove to be of clinical value too.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1469-7610.2000.tb02345.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Are Only Children Different? A Study of Child Psychiatric Referrals. A Research Note (1996)
    Oxford, UK : Blackwell Publishing Ltd
    The @journal of child psychology and psychiatry 37 (1996), S. 0 
    Details
    ISSN: 1469-7610
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: For this study, 683 only children seen in a psychiatric clinic were compared with 2364 children from two-child families seen in the same clinic. From the age of 5 years, there were no differences between the two groups. Among the under-5s, a higher proportion of only children had problems which did not warrant a psychiatric diagnosis, and their parents were more often rated as being over-protective. Our findings suggest, however, that the parents of only children differ from other parents not in being more over-protective but in being more willing or able to seek medical advice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1469-7610.1996.tb01468.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Mercuric resistance genes in gram-positive oral bacteria (2004)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 236 (2004), S. 0 
    Details
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Mercury-resistant bacteria isolated from the oral cavities of children carried one of two types of merA gene that appear to have evolved from a common ancestor. Streptococcus oralis, Streptococcus mitis and a few other species had merA genes that were very similar to merA of Bacillus cereus strain RC607. Unlike the B. cereus RC607 merA gene, however, the streptococcal merA genes were not carried on Tn5084-like transposons. Instead, comparisons with microbial genomic sequences suggest the merA gene is located on a novel type II transposon. Coagulase-negative staphylococci and Streptococcus parasanguis had identical merA genes that represent a new merA variant.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1574-6968.2004.tb09649.x
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  • 5
    Electronic Resource
    Electronic Resource
    Locomotion and feeding of Acanthamoeba at the water–air interface of ponds (2001)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 194 (2001), S. 0 
    Details
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Acanthamoeba trophozoites attach to and effect amoeboid locomotion at the water–air interface of ponds. Their locomotory rate (∼0.8 μm s−1) and manner of independent movement at this interface is similar to that over solid substrata. Adhesion forces developed between amoebae and the water–air interface are greater than gravity and thus amoebae are also transported passively without detachment. Amoebae docked with the water–air interface remain and flourish here as they are shown, by using green fluorescent protein-labelled Aeromonas hydrophila, to feed on bacteria that occur at the interface, digesting them intracellularly.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1574-6968.2001.tb09459.x
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  • 6
    Electronic Resource
    Electronic Resource
    Stability of plasmid vector plJ303 in Streptomyces lividans TK24 during laboratory-scale fermentations (1993)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 41 (1993), S. 148-155 
    Details
    ISSN: 0006-3592
    Keywords: plasmid stability ; Streptomyces lividans ; fermentation ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Plasmid plJ303 stability in Streptomyces lividans cultures has been studied by measuring plasmid copy number under various growth conditions. An increase in mean plasmid copy number was normally seen during early rapid growth in both shaken culture and stirred vessel fermentations at 28°C. Maximum copy numbers were consistently attained in early stationary phase followed by a decline (of variable amount) upon further incubation. The imposition of environmental stress (high growth temperature, i.e., 37°C, and low dissolved oxygen tension, i.e., 〈5% air saturation) led to a plasmid copy number of zero and a 50% reduction, respectively. Interestingly, the relative proportions of plasmid topoisomers changed with time since progressively more supercoiled forms were observed throughout the stationary phase. Plasmid dimers were also observed in some cultures, and no evidence of structural plasmid instability was found. In general, this host-vector system seemed remarkably stable under normal growth conditions. However, copious organic acid production by the host was observed and was thought to be undesirable for good heterologous gene expression of a secreted protein. © 1993 John Wiley & Sons, Inc.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260410119
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