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  • 1
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The effect of intermittent light stimulation (ILS) on the distribution of thiamine derivatives in three brain areas (occipital, motor, and premotor) was compared in photosensitive and nonphotosensitive baboons. ILS induces paroxysmal discharges in the motor and premotor areas of photosensitive animals only. In baboons submitted to ILS, thiamine triphosphate (TTP) decreases in both photosensitive and nonphotosensitive animals; thiamine monophosphate (TMP) increases in photosensitive animals, which present ILS-induced paroxysmal discharges, whereas it is unaffected in nonphotosensitive animals. The variations are the most significant in the occipital (visual) cortex. A consumption of TTP may result from electrical activity induced by light stimulation in the occipital area. No correlation between ILS-induced paroxysmal activity and a decrease in TTP contents was found. However, photosensitive animals are affected differently from nonphotosensitive animals, as their content of TMP in the cerebral cortex increases on stimulation. However, as long as the exact role of thiamine compounds in relation to membrane excitability in the nervous system remains unknown, it is impossible to conclude whether the differences observed in the metabolism of thiamine compounds are the cause or the consequence of the photosensitivity in the baboon Papio papio.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 0022-328X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Regulatory Peptides 2 (1981), S. 383-390 
    ISSN: 0167-0115
    Keywords: FK 33,824 ; baboons ; enkephalins ; epilepsy ; hippocampus ; morphine ; seizures
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1106
    Keywords: Huntington's disease ; Excitotoxins ; Primates ; Caudate-putamen ; Neuronal transplantation ; Cross-species ; Fetal striatum ; Morphology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Ibotenic acid was injected unilaterally into the baboon caudate-putamen (CP) to achieve a neural degeneration model in the primate, with a neuropathology similar to Huntington's disease. Four to six weeks later injections of cell suspensions of striatal precursor cells, obtained by dissection of the fetal rat striatal region (13–15 days gestational age), were made into the excitotoxically lesioned CP of 3 baboons immunosuppressed by Cyclosporin A. Morphological analysis indicated that in one of the baboons, which had the largest lesion of the CP and the shortest survival time (6 weeks after implantation), there was a surviving striatal implant. The implanted neurons grew in high densities in cellular aggregates within the host gliotic CP. These neurons had a neuronal size phenotypical for rat striatum, i.e. on average about a 25% smaller neuronal cell diameter than a similar population in the baboon caudate-putamen. Glial-fibrillary-acid-protein immunoreactivity was present on large astrocytes within the striatal implant, with a distinct border towards the lesion-induced astrogliosis of the host. Neuronal markers for acetylcholinesterase and Leu-enkephalin were distributed in a typical patchy manner in the striatal implants along with fiber staining for tyrosine-hydroxylase-like immunoreactivity (TH) possibly derived from afferent host dopaminergic axons. Some of these fibers in the implants came from intrinsic TH-positive neuronal somata, probably of neocortical fetal origin and transiently expressing the enzyme. In conclusion, the results indicate that neuronal replacement can be achieved by crossspecies implantation of fetal striatal precursor cells to the previously neuron depleted primate CP under immunosuppression but that the survival and growth of such implants may be variable and subject to unfavourable trophic conditions.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Neurological sciences 8 (1987), S. 437-447 
    ISSN: 1590-3478
    Keywords: Photic epilepsy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario I dati raccolti in 30 anni di studi nell’uomo e in differenti animali, ma specialmente sui babbuini Paio Papio tendono a dimostrare che la corteccia gioca un ruolo determinante sulle scariche ittali e interittali indotte dalla stimolazione luminosa intermittente nell’epilessia fotosensitiva. Due regioni corticali hanno un ruolo preminente: quella frontorolandica e la occipitale. La corteccia può, infatti, trasmettere o controllare gli afferenti visivi alla regione frontorolandica e può determinare scariche intermittenti in alcune specifiche condizioni nel babbuino e in alcuni, particolari pazienti fra gli uomini. La via cortico-corticale trasporta gli impulsi visivi alla corteccia frontorolandica ed è certamente modulata dalle strutture profonde come il sistema reticolare e il talamo. Per il momento non si può dire di più in quanto occorrono ulteriori e complementari esperimenti.
    Notes: Abstract The data gathered in 30 years’ study in man and in several animal species, but especially in the Papio papio baboon, tend to show that the cortex plays a decisive part in the seizure and interval discharges induced by intermittent light stimulation in photic epilepsy. two regions of the cortex predominate: the frontorolandic and occipital regions. The cortical cortex can, indeed, transmit or control the visual input to the frontorolandic region and can cause intermittent discharges in certain specific conditions in baboons and in certain human patients. The corticocortical pathway conveys the visual impulses to the frontorolandic cortex and is certainly modulated by deep structures like the reticular systems and the thalamus. At present no more can be said since further research is needed.
    Type of Medium: Electronic Resource
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