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  • 1
    Electronic Resource
    Electronic Resource
    Spinal bone mass after long-term treatment with L-Thyroxine in postmenopausal women with thyroid cancer and chronic lymphocytic thyroiditis (1994)
    Springer
    Calcified tissue international 54 (1994), S. 16-19 
    Details
    ISSN: 1432-0827
    Keywords: Bone loss ; L-Thyroxine ; Thyroid cancer ; Chronic lymphocytic thyroiditis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract This study investigated the effect of long-term treatment upon bone density with L-Thyroxine in postmenopausal women compared with untreated postmenopausal women with climacteric symptoms. We measured spinal bone density in three groups (n=84) of postmenopausal women: (A) those treated with TSH-suppressive dosis of L-Thyroxine for a medium of 5 years after removal of thyroid cancer; (B) those on L-Thyroxine treatment for a median of 9 years after being diagnosed with chronic lynfocitic thyroiditis (CLT); and (C) those with no thyroid disease or other known pathology and without any treatment. There were no differences in dietary calcium intake and daily activity between untreated and L-Thyroxine-treated women. Measurements of bone mineral density were performed at spine level L1–L4 using a dual X-ray densitometer and serum thyroid-stimulating hormone (TSH), thyroid hormones, and bone markers (serum osteocalcin, procollagen I, urinary calcium), and PTH levels were assayed and found to be within normal ranges. Women receiving L-Thyroxine after thyroid cancer had slightly higher FT4 levels compared with women who had CLT and lower TSH levels, with serum T4 and T3 levels normal and similar in both groups. No significant differences were found in spinal bone density after L-Thyroxine treatment between Groups A and B and compared with Group C. Bone loss according to 2 SD below reference standards (age and sex matched) was found in the 12.9% of L-Thyroxine-treated patients versus 22.6% of untreated women. No correlation was found between bone loss and thyroid hormone levels and duration of treatment. Our data suggest that long-term L-Thyroxine therapy in postmenopausal women maintaining near physiological levels of thyroid hormones is not associated with significant axial bone loss, therefore other factors should be considered when this occurs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00316283
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    ISO Spectroscopy of Ultraluminous Infrared Galaxies (1999)
    Springer
    Astrophysics and space science 266 (1999), S. 85-90 
    Details
    ISSN: 1572-946X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Spectroscopy from the Infrared Space Observatory ISO has for the first timeprovided the sensitivity to exploit the diagnostic power ofmid-infrared fine structure lines and PAH features for the study ofultraluminous infrared galaxies (LIR 〉1012 L ⊙). We report on observations obtainedwith SWS, ISOPHOT-S, and the CVF option of ISOCAM. From both fine structure lines and PAH features, we find that the majority of ULIRGs is predominantlypowered by star formation. Our total sample of about 75 ULIRGs allows tosearch for trends within the class of ULIRGs: The fraction of AGNs increaseswith luminosity above ∼ 3 × 1012L⊙ but there is no obvioustrend for ULIRGs to be more AGN-like with more advanced merger phase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1002689312663
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Morphology and Evolution of Ultraluminous IR Galaxies (1999)
    Springer
    Astrophysics and space science 269-270 (1999), S. 399-402 
    Details
    ISSN: 1572-946X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Ultraluminous infrared galaxies (ULIRGs) are probably the local analogues of a major mode of galaxy formation in the early universe. Here we give a brief progress report on our on-going programme to study the nature and evolution of ULIRGs. Our near-IR imaging of a large sample of these highly disturbed merger systems provides a data base of morphological parameters like tidal features or projected separation of the nuclei. Together with ISO Mid-IR spectroscopy these morphological parameters allow us to explore the merger dynamics and evolution of ULIRGs as they may progress from starburst to buried AGN to exposed QSO. We find that the fraction of ULIRGs predominantly powered by AGNs increases with luminosity above ∼ 3 × 1012 L⊙, but that there is no obvious trend for ULIRGs to be more AGN-like with more advanced merger phase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1017017618384
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Bone Changes in Pre- and Postmenopausal Women with Thyroid Cancer on Levothyroxine Therapy: Evolution of Axial and Appendicular Bone Mass (1998)
    Springer
    Osteoporosis international 8 (1998), S. 311-316 
    Details
    ISSN: 1433-2965
    Keywords: Key words:Bone mass – Bone metabolism – LT4 treatment – Subclinical hyperthyroidism – Thyroid cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: The effects of suppressive doses of levothyroxine (LT4) on bone mass are controversial. Our aim was to evaluate the effects on axial and appendicular bone mineral density (BMD) and bone metabolism of long-term LT4 suppressive therapy in women by means of cross-sectional and longitudinal studies, and also to assess the potential influence of menopausal status and LT4 dose. Seventy-six women (aged 47 + 13 years, 37 pre- and 39 postmenopausal) on suppressive therapy (67 + 34 months duration, mean LT4 dose 168 + 41 mg/day) from our Thyroid Cancer Unit without previous hyperthyroidism or concomitant hypoparathyroidism were studied. Serum TSH, T3 free T4, calcium, phosphorus, alkaline phosphatase, BGP, iPTH and urinary calcium (uCA) were measured. BMD was measured by dual-energy X-ray absorptiometry (DXA) at lumbar spine, femoral neck, Ward's triangle, ultradistal and distal third radius and expressed as a Z-score. In a subset of 27 women aged 46 + 15 years (14 pre- and 13 postmenopausal) a second densitometry scan was performed 27 + 5 months later. Patients on suppressive therapy showed a small reduction in BMD at the distal third radius (Z-score: 70.77 + 0.98; 95% confidence interval: 71.11, 70.44) without differences between pre- and postmenopausal women. Significant relations with the regimen of suppressive therapy and bone turnover markers were detected except at the lumbar spine. In the longitudinal study a significant although mild reduction in femoral neck BMD was found that correlated with prior T3 and iPTH. In conclusion, our data show a small detrimental effect of cautious LT4 suppressive therapy on bone mass assessed by DXA; it remains to be established whether this increases the prevalence of fractures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001980050069
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    Paper (German National Licenses)
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