ISSN:
1432-2307
Keywords:
Generalized mastocytosis
;
Systemic mast cell disease
;
Splenic mastocytosis
;
Mastocytosis with acute leukaemia
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Three cases of splenic involvement in three different types of generalized mastocytosis (systemic mast cell disease) are reported. The macroscopic, histological and ultrastructural modifications of the spleen are described. Each case exhibited a different morphological pattern. Giemsa staining, fluorescence after acridine orange staining and naphthol ASD chloracetate esterase reaction are shown to be valuable for diagnosis. By comparison, immunohistochemistry seemed not to be very useful, because no specific antigens are expressed. These findings are compared to previously published cases. Their value for the diagnosis and the prognosis are discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01606518
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