ISSN:
1432-2072
Keywords:
Choline Acetyltransferase Inhibitor
;
Scopolamine
;
Psycho-pharmacology
;
Potentiation
;
Drug Metabolism
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract A selective inhibitor of choline acetyltransferase, 4-(1-naphthylvinyl) pyridine hydrochloride (NVP), was compared with a central cholinergic antagonist, scopolamine, in a number of behavioral procedures in rats. Scopolamine (1 mg/kg, i.p.) caused alterations in performance of animals trained on nondiscriminated avoidance, punishment discrimination and conditioned suppression behavior, and had no effect on discrete avoidance behavior after doses as high as 8 mg/kg. After nonataxic doses (10–50 mg/kg, i.p.), NVP had no inhibitory effects in these behavioral schedules, and only after higher doses (100–200 mg/kg, i.p.) was an inhibitory effect on discrete avoidance obtained. It is suggested that less than complete inhibition of choline acetyltransferase does not provide sufficient attenuation of central cholinergic function to mimic the behavioral effects of a cholinergic antagonist. NVP was found to potentiate the pharmacological effects of chlorpromazine and physostigmine, suggesting an inhibitory action on drug metabolizing enzymes; it also had a protective effect upon maximal electroshock seizures in mice.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00414412
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