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  • 1
    Electronic Resource
    Electronic Resource
    k-Binding and Degradation of [3H]Dynorphin A (1–8) and [3H]Dynorphin A (1–9) in Suspensions of Guinea Pig Brain Membranes (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 45 (1985), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Following incubation of [3H]dynorphin A (1–8) and [3H]dynorphin A (1–9) with suspensions of guinea pig brain membranes, analysis of the supernatants by HPLC has shown that both peptides are degraded at 25°C and at 0°C. Bestatin and captopril reduce degradation at 0°C but for a similar degree of protection at 25°C argininecontaining dipeptides are also required. The effects of these peptidase inhibitors on the degradation profiles indicate that [3H]dynorphin A (1–8) has three main sites of cleavage: the Tyr1-Gly2, Arg6-Arg7, and Leu5-Arg6 bonds. With [3H]dynorphin A (1–9) as substrate the Arg7-Ile8 and Ile8-Arg9 bonds are also liable to cleavage. In binding assays, in contrast to the effects of peptidase inhibitors on the degradation of unbound [3H]dynorphin A (1–8) and [3H]dynorphin A (1–9), bestatin and captopril have little effect on the binding characteristics of the tritiated dynorphin A fragments at the k-site at 0°C. However, at 25°C binding is low in the absence of peptidase inhibitors. When binding at μ- and δ-sites is prevented, the maximal binding capacities of [3H]dynorphin A (1–8), [3H]dynorphin A (1–9), and [3H](–)-bremazocine at the k-site are similar; [3H]dynorphin A (1–9) has 5–10 times higher affinity for the k-site than [3H]dynorphin A (1–8). Comparison of the effects of peptidase inhibitors on unbound dynorphin A fragments with their effects in binding assays suggests that the bound peptides are protected from the action of peptidases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1985.tb05520.x
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  • 2
    Electronic Resource
    Electronic Resource
    EDI - Changing Business Practice (1994)
    Bradford : Emerald
    Logistics information management 7 (1994), S. 35-40 
    Details
    ISSN: 0957-6053
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Economics
    Notes: The need to hasten the exchange of business information over the yearshas resulted in ever-changing business practices culminating in theadvent of electronic data interchange (EDI). Looks at the progress ofEDI, the evolution of the syntax used for EDI messages and the servicesavailable for the electronic transmission of EDI data. As EDI softwarehas become more sophisticated so have its applications and these trendsare illustrated by a series of case studies involving largemultinationals with dedicated IT departments as well as smallorganizations, often with no computer knowledge at all. The automotiveindustry is one sector which is earnestly implementing EDI to maximizeits full potential. There is an increasing trend towards the formationof EDI communities to keep costs down and for the mutual benefit ofcommunity members. Opportunities available to future generations of EDIusers include continuous dialogue simulating conversation betweencomputers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1108/09576059410066417
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Age-associated changes in the electrophoretic pattern of the high molecular weight non-histone proteins from mouse liver, hepatoma and spleen chromatin (1980)
    Springer
    Age 3 (1980), S. 74-77 
    Details
    ISSN: 1574-4647
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The water-soluble fractions of non-histone chromatin (NHC) proteins were isolated from 0.35M NaCl extracts of liver and spleen chromatin of young and old CBA mice and hepatomas of old mice. SDS-disc electrophoretic patterns of proteins with higher molecular weight were compared. Tissue specificity and age changes of the patterns have been found; however, in spleen chromatin the differences of NHC proteins associated with aging were insignificant. Age-associated changes of NHC proteins in liver (increase of number of minor protein fractions) are not found in chromatin from hepatomas which indicates that the changes of the pattern of NHC proteins in aged liver cells are probably reversible.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02431731
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    The effects of vitamin B6 deficiency on the bone marrow of the rat1 (1978)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 191 (1978), S. 47-53 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Bone marrow from adult rats fed a vitamin B6 deficient diet for two weeks was found to have reduced numbers of neutrophils, erythroid cells and small lymphocytes. The numbers of transitional cells were not reduced. Since the small lymphocyte population in the bone marrow consists of B cells and null cells in approximately the same proportion, it was concluded that both cell types were reduced as a result of the deficiency. A complete recovery in the cellularity of the bone marrow was brought about by returning the vitamin B6 deficient animals to a normal diet for four weeks. Other effects of the two-week vitamin B6 deficient diet included a failure to gain weight, a decrease in thymus weight and a reduction in the numbers of white blood cells in the peripheral blood. All of these defects were corrected after the animals had been fed a normal diet for four weeks.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091910105
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    Paper (German National Licenses)
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