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  • 1
    Electronic Resource
    Electronic Resource
    The rna2 mutation of yeast affects the processing of actin mRNA as well as ribosomal protein mRNAs (1983)
    Springer
    Molecular genetics and genomics 192 (1983), S. 101-103 
    Details
    ISSN: 1617-4623
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The temperature sensitive rna2 mutation of Saccharomyces cerevisiae causes a rapid and dramatic decrease in the abundance of most ribosomal protein mRNAs [6, 14]. We and others have recently shown that the processing of ribosomal protein mRNAs is defective at the nonpermissive temperature, suggesting that inefficient mRNA processing might be responsible for the decline in ribosomal protein mRNA levels [2, 4, 8, 11]. Actin is the only known intron-containing non-ribosomal protein yeast nuclear gene [5, 10]. We show here that the processing of actin mRNA is also defective at the nonpermissive temperature in rna2-containing strains. The observation supports the notion that all intron-containing genes are affected in a similar fashion by the rna2 mutation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00327653
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  • 2
    Electronic Resource
    Electronic Resource
    Yeast myosin heavy chain mutant: Maintenance of the cell type specific budding pattern and the normal deposition of chitin and cell wall components requires an intact myosin heavy chain gene (1990)
    New York, NY : Wiley-Blackwell
    Cell Motility and the Cytoskeleton 17 (1990), S. 301-308 
    Details
    ISSN: 0886-1544
    Keywords: yeast ; myosin ; budding ; cell wall ; cytoskeleton ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Recent studies with myosin heavy chain mutants in the slime mold Dictyostelium discoideum and the yeast Saccharoymyces cerevisiae indicate that the myosin heavy chain gene is not essential for cell survival under laboratory growth conditions. However, cells lacking a normal myosin heavy chain gene demonstrate substantial alterations in growth and cell division. In this study, we report that a disruption mutant in the rod portion of the yeast myosin heavy chain gene, MYOl, produces abnormal chitin distribution and cell wall organization at the mother-bud neck in a high proportion of dividing cells. It is suggested that this phenotype is the cause of the cell division defect and the osmotic sensitivity of yeast MYOl mutants. In the absence of a normal MYOl polypeptide, yeast cells alter their cell type specific budding pattern. It is concluded that an intact myosin heavy chain gene is required to maintain the cell type specific budding pattern and the correct localization and deposition of chitin and cell wall components during cell growth and division.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cm.970170405
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Electrochemical oxidation of dacarbazine and its major metabolite (AIC) on carbon electrodes (1989)
    Weinheim : Wiley-Blackwell
    Electroanalysis 1 (1989), S. 529-534 
    Details
    ISSN: 1040-0397
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The electrochemical behavior of the antitumor agent dacarbazine (DTIC) and its major metabolite, 5-aminoimidazole-4-carboxamide (AIC), on carbon paste electrodes has been studied. Linear sweep voltammetry (LSV) and differential pulse voltammetry (DPV) have been applied, showing that both molecules are active in oxidation. Both compounds are oxidized in a two-electron process, presenting a charge transfer coefficients (β) of 0.44 ± 0.03 and 0.48 ± 0.03 for DTIC and AIC, respectively, which indicate slow processes. The oxidation mechanisms proposed for each of these compounds seem to yield the same final product, the 5-hydroxyimidazol-4-carboxamide. DPV proved to be a valuable analytical technique that is suitable for distinguishing and analyzing both compounds when the most adequate medium (0.1 M HCIO4) and operating conditions are chosen.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/elan.1140010609
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    Paper (German National Licenses)
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