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  • 1
    Electronic Resource
    Electronic Resource
    Trophic effects of neurotensin in massive bowel resection in the rat (1994)
    Springer
    Digestive diseases and sciences 39 (1994), S. 59-64 
    Details
    ISSN: 1573-2568
    Keywords: neurotensin ; enteroglucagon ; bowel resection ; intestinal adaptation ; rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The trophic effect of the administration of exogenous neurotensin on the intestinal mucosa was studied in rats following an 80% bowel resection. Villus length and mucosal DNA content were assessed in the jejunal and ileal mucosa of the remnant intestine 14 days after resection. The data obtained in an 80% resected control group (80% group) and an experimental group receiving an infusion of neurotensin (300 µg/kg/day) for 14 days subcutaneously (80%+NT group) were compared. The results indicate that the administration of exogenous neurotensin (80%+NT) increases villus length (jejunum: 920±77 vs 861±25 µm and ileum length: 975±23 vs 875±99 µm) to an extent greater than that observed in the 80% resected group not receiving exogenous neurotensin. The levels of mucosal DNA per milligram of protein increased significantly in both groups but was paradoxically less in the 80%+NT group than in the 80% resection group (jejunum: 8±0.56 vs 10.18±0.80; ileum; 8.63±0.43 vs 10.05±0.46). These data suggest that the administration of exogenous neurotensin to the rat potentiates the growth of intestinal villi and accelerates the intestinal trophic response seen following massive bowel resection. The increase in circulating enteroglucagon levels noted after neurotensin administration (80%+NT: 547±48 pg/ml vs 80%: 341±41 pg/ml) suggests that some of the trophic effects of neurotensin may be mediated, at least in part, by enteroglucagon. These data also suggest a potential role for the use of neurotensin in the initial treatment of individuals with short bowel syndrome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02090061
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Plasma enteroglucagon levels in different models of intestinal resection in the rat (1994)
    Springer
    Digestive diseases and sciences 39 (1994), S. 65-68 
    Details
    ISSN: 1573-2568
    Keywords: enteroglucagon ; intestinal resection ; rat ; intestinal adaptation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To assess the influence of the different intestinal segments on the plasma enteroglucagon level, three models of intestinal resection in the rat were studied (jejunal, ileal, 90%). The basal values for this peptide and those obtained after an infusion of intraduodenal glucose were compared. The results obtained in basal/post-glucose infusion were: 50% proximal (jejunum): 220/728 pg/ml; 50% distal (ileum): 10/233 pg/ml; and the middle 90%: 108/297 pg/ml. The glucose infusion produced a maximal response, permitting a better evaluation of the differences among the three resection models. The highest levels corresponded to the group in which the entire ileum was conserved.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02090062
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Effect of colistin on reduction of biliary flow induced by endotoxin ofE. coli (1982)
    Springer
    Digestive diseases and sciences 27 (1982), S. 875-879 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In order to evaluate whether an antiendotoxin agent can inhibit the action of endotoxin ofEscherichia coli on biliary flow, we used 18 models of isolated perfused pig liver divided into four groups: (A) five perfused livers (control), (B) five perfused livers with 2 mg/100 ml of endotoxin added, (C) five perfused livers with 2 mg/100 ml of endotoxin added and treated with 1,500,000 IU of colistin, and (D) three perfused livers with 1,500,000 IU of colistin with no endotoxin. The livers were isolated and perfused according to a technique previously described by our laboratory. The viability of the perfusions was controlled by means of the mitochondrial respiration test. Transaminase and LDH levels were measured in the perfusion circuit. A significant reduction of the biliary flow was found in the group with endotoxin ofEscherichia coli (P〈0.002). There was no reduction of biliary flow after addition of 1,500,000 IU of colistin (P〈 0.001). No significant changes were observed in the other parameters measured, and no increase of the bile flow was observed in the colistin group. From our results we conclude that colistin is an inhibitorin vitro of the diminished biliary flow induced by endotoxin ofEscherichia coli.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01316569
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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