ISSN:
1573-7233
Keywords:
prostacyclin
;
thromboxane A2
;
6-keto-PGF1α
;
2,3-dinor-6-keto-PGF1α
;
2,3-dinor-TXB2
;
nafazatrom
;
breast cancer
;
ovarian cancer
;
cervix cancer
;
leiomyonas
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Studies investigating the role of thromboxane A2 and prostacyclin in cancer of the female breast and genital tract are reviewed. Whereas thromboxane A2 was found to promote the tumour growth and metastasis, prostacyclin exerted a protective effect in maintaining vascular and platelet homeostasis. Thus, monitoring of prostacyclin and thromboxane levels in plasma and urine of cancer patients may be essential for the evaluation of tumour growth and metastasis. Of all modulators of thromboxane and prostacyclin biosynthesis, nafazatrom was found to exhibit promising results for the treatment of advanced breast cancer, although its use in the routine therapy is questionable at this stage.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01307190
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