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  • 1
    Electronic Resource
    Electronic Resource
    Development and Validation of the Mini-Osteoporosis Quality of Life Questionnaire (OQLQ) in Osteoporotic Women with Back Pain due to Vertebral Fractures. Osteoporosis Quality of Life Study Group (1999)
    Springer
    Osteoporosis international 10 (1999), S. 207-213 
    Details
    ISSN: 1433-2965
    Keywords: Key words: Clinical settings – Osteoporosis – Quality of life – Shortened questionnaire – Vertebral fractures
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: The objective of the study was to evaluate a shortened osteoporosis quality of life questionnaire (OQLQ) in osteoporotic women with back pain due to vertebral fractures. From the longer 30-item OQLQ (four to nine items per domain) we created the mini-OQLQ by choosing the two items with the highest impact in each of five domains (symptoms, physical function, activities of daily living, emotional function, leisure). We administered the OQLQ, the Sickness Impact Profile, the SF-36 and the Brief Pain Index to patients at baseline, after 2 weeks and after 6 months. The intraclass correlations between baseline and the 2-week follow-up for the five mini-OQLQ domains ranged from 0.72 to 0.86. Cross-sectional correlations between the domains of the mini-OQLQ and other health instruments were moderate to large (0.35–0.80) and greater than predicted. The mini-OQLQ items showed moderate to large correlations with items omitted from the shortened questionnaire (0.44–0.88). Correlations between the OQLQ domains and the other three instruments were greater than those of the mini-OQLQ, and partial correlations between OQLQ items omitted from the mini-OQLQ and the other three instruments after considering mini-OQLQ items were substantial (0.19–0.71) and statistically significant. Sample sizes of less than 200 per group should be required to detect minimally important differences in parallel-group clinical trials. Longitudinal correlations between the mini-OQLQ and the other measures were often significant but generally lower than predicted (0.10–0.49). The partial correlations revealed that the omitted items explained a significant portion of the longitudinal variance in each domain. We conclude that in a selected group of patients with back pain caused by vertebral fractures, the mini-OQLQ demonstrated good discriminative and adequate evaluative properties. The mini-questionnaire should be useful in clinical settings.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001980050217
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  • 2
    Electronic Resource
    Electronic Resource
    Health-Related Quality of Life and Participation in Osteoporosis Clinical Trials (1998)
    Springer
    Calcified tissue international 62 (1998), S. 189-192 
    Details
    ISSN: 1432-0827
    Keywords: Key words: Clinical trials — Osteoporosis — Health-related quality of life — Quality of life — OQLQ.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. Although osteoporosis affects millions of elderly women, the quality of their lives is extremely complex and is only recently being appreciated. We recently used a disease-specific Osteoporosis Quality of Life questionnaire (OQLQ) to measure quality of life for 105 elderly osteoporotic women, and reported that by path analysis, spinal fractures, health perception, and several sociodemographic factors accounted for 63% of the variance in quality of life. On the other hand, bone density, Colles fracture, hip fractures, pharmacologic agents, exercise, and several sociodemographic variables were not significant factors. Of particular note was the positive, indirect effect (via health perception and spinal fractures) that participation in a clinical trial (17.5% of the patients) had on life quality. In order to determine how involvement in a research study might affect health perception in this same cohort we examined OQLQ scores in the five domains of the OQLQ for the 18 postmenopausal osteoporotic women enrolled in two different phase III clinical trials with oral bisphosphonates and 87 osteoporotic women treated conventionally (estrogen, bisphosphonate, calcitonin, calcium/vitamin D) in our metabolic bone clinic. Research and clinical patients did not differ in age, femoral BMD, or number of spinal fractures. However, women in research trials had significantly greater aggregate OQLQ scores (5.67 versus 4.23, P 〈 0.0001) and perceived health (7.28 versus 5.85, P= 0.001) than clinical patients. These differences were highly significant (P 〈 0.001) for domains of quality of life including physical function, activities of daily living, symptoms, and leisure/social activity and marginally significant for the emotional function domain (P= 0.05). Hence, by regression-based path analysis and subgroup analysis of cross-sectional data, participation in a clinical trial had a significant and positive impact on health-related quality of life. If these findings are confirmed by other studies, identifying those factors inherent in clinical studies that positively impact the lives of osteoporotic patients should become as important a priority as development of new therapies for this chronic disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002239900415
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Influence of root zone oxygen stress on potassium and ammonium absorption by Myrobalan plum rootstock (1984)
    Springer
    Plant and soil 80 (1984), S. 345-353 
    Details
    ISSN: 1573-5036
    Keywords: Ammonium ; Anaerobiosis ; Ion absorption ; Ion efflux ; Myrobalan plum rootstock ; Oxygen stress ; Potassium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary Growth chamber experiments were conducted with ‘French’ prune (Prunus domestica L.) scions grafted on Myrobalan 29C (P. cerasifera Ehrh.) rootstocks grown in nutrient solution to characterize K and NH4 uptake before, during, and after anaerobiosis. Conditions of oxygen stress were imposed by removing the source of aeration and bubbling solutions with nitrogen gas. At solution oxygen concentrations less than 1%, K leaked from plant roots. After 18 h of anaerobic conditions, aeration was restored and K depletion from solution occurred within 2 h. Uptake of K the following day was similar to that before oxygen stress was imposed. Under similar conditions with solution oxygen concentrations less than 1%, both K and NH4 uptake were inhibited. Potassium leakage from roots was significantly greater than that of NH4. The presence of NH4 had no significant effect on K leakage from roots. Signs of wilting during oxygen stress appeared first on those trees that received NH4. Potassium uptake by rootstocks in the presence of NH4 was inhibited prior to and following anaerobiosis. However, the extent of NH4-induced inhibition of K uptake before anaerobiosis was similar to the K uptake inhibition after anaerobiosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02140041
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    Paper (German National Licenses)
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