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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 31 (1975), S. 573-575 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Bei normaler Ernährung und täglichem Trinken von beliebigen Mengen 40% igem Zuckerrohrschnaps wurden bei weissen Laboratoriumsratten diverse anatomische und ultrastrukturelle Lungenveränderungen nachgewiesen: Hypertrophie und Hyperplasie der Pneumocyten vom Typ 2, Anhäufung intraalveolärer Makrophagen und Verdickung der Alveolarwände.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 31 (1975), S. 82-83 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Bei Ratten, die während 4 Monaten ad libitum 40% igen Zuckerrohrschnaps getrunken hatten, wurden tiefgreifende Degenerationserscheinungen des adrenergischen Nervenplexus der Atrioventrikularklappen festgestellt.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Inflammation research 34 (1991), S. 295-301 
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Fragments of rat mesentery were examined using acetylthiocholine to detect cholinergic nerve fibers and toluidine blue to identify mast cells. 59.2±2.6 percent of mast cells were at less than one-half mean cell diameter (4–5 μm), from the nerve fibers. Under the electron microscope, the membrane of mast cells was within less than 50 nm from axon membranes, suggesting a synaptic type of connection. Average mast cell area in fasted rats increased following feeding, stimulation of the left abdominal vagus nerve or exposure of the animal to the smell of food. It returned to control values within 60–80 min. Granule exocytosis was not observed. Mast cell swelling was prevented by atropine and induced by intravenously administered carbamylcholine. It appears that in rat mesentery, impulses travelling via cholinergic, parasympathetic fibers innervating mast cells, cause mast cell swelling. Compound 48/80 administered to rats at doses causing little degranulation and minimum release of histamine, caused extensive, reversible swelling of mesentery mast cells.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 32 (1976), S. 206-208 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The effect of long-term alcohol ingestion on the norepinephrine concentration of the heart was investigated in rats. The alcoholic animals showed a highly significant increase in cardiac norepinephrine concentration as compared with the corresponding controls. It is further suggested that continued exposure to high levels of norepinephrine may play a role in the development of cardiomyopathy in chronic alcoholism.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 32 (1976), S. 614-616 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Chronic administration of alcohol to well-nourished rats led to striking changes in the small intestinal cell population. The present experiments corroborate the view that alcohol is directly toxic to the small intestine.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 29 (1973), S. 1272-1274 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Elektronenoptischer Nachweis, dass Skorpiongift (Tityus serrulatus) nach i.p. Verabreichung an der quergestreiften Muskulatur der Küchenschabe eine starke nekrosierende Wirkung ausübt.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Mittels Fluoreszenztechnik wurde ein mikrochemischer Nachweis der Freisetzung von Katecholamin an adrenergischen Strukturen in den Arterioventrikularklappen des Rattenherzens nach Verabreichung von Skorpiongift (Tityus serrulatus) erbracht.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Neurological sciences 15 (1994), S. 145-149 
    ISSN: 1590-3478
    Keywords: cerebral ischemia ; etiology ; cardiopathy ; foramen ovale ; paradoxical ; embolism ; young ; echocardiography ; contrast
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario La prevalenza della pervietà del forame ovale (PFO) è stata studiata, per mezzo della Eco-cardiografia transtoracica con iniezione di mezzo di contrasto, in una serie continua di 48 pazienti di età inferiore ai 50 anni, affetti da episodi acuti di ischemia cerebrale focale. La presenza di PFO è stata dimostrata in 11 soggetti (23%). Nel gruppo dei più giovani (sotto i 30 anni) la prevalenza di questa anomalia cardiaca è risultata molto più alta che in quello dei più anziani (58% contro 11%, p=0,0022). Inoltre, non vi era alcun caso di PFO tra i 19 soggetti in cui è stata dimostrata una evidente causa extracardiaca del disturbo cerebrovascolare, mentre la PFO era presente nel 38% degli altri 29 casi (p=0.0015). In conclusione, la presenza di PFO deve essere ricercata con cura nei pazienti cerebrovascolari ischemici di età inferiore a 30 anni così come in quelli tra i 30 ed i 50 in cui non sia dimostrabile una verosimile causa dell'episodio ischemico cerebrale.
    Notes: Abstract By means of transthoracic contrast echocardiography, the prevalence of a patent foramen ovale (PFO) was studied, in a continuous series of 48 patients aged less than 50 years with a recent episode of acute cerebral ischemia. A PFO was found in 11 subjects (23%). In the subgroup of younger patients (aged less than 30 years), the prevalence was much higher than in those aged 30 or more (58% against 11%, p=0.0022). In the 19 patients with clear evidence of extracardiac causal factors of cerebral ischemia, there was no PFO; of the remaining 29 subjects, a PFO was present in 11 (38%) (p=0.0015). In conclusion, the possibile presence of a PFO must be carefully investigated in subjects with cerebral ischemia aged less than 30, as well as in subjects aged between 30 and 50 in whom there is no acceptable explanation for their cerebral ischemic episode.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Research in experimental medicine 185 (1985), S. 283-290 
    ISSN: 1433-8580
    Keywords: Experimental nephropathy ; Forssman antibody ; Mesangial nephropathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In the present work the involvement of the kidneys of guinea pigs injected with rabbit anti-sheep red blood cell antiserum (Forssman antibody) was studied. The antibody was introduced by a catheter into the abdominal aorta close to the openings of renal arteries. Glomerular lesions were observed 6h following the injection: increased cellularity at the expense of polymorphonuclear and mononuclear cells, widened mesangial regions, deposits of fuchsinophilic material in the mesangium and capillary loops. By immunofluorescence the antibody was detected in the mesangial region extending to adjacent capillary loops, but it was not possible to demonstrate the presence of complement with certainty. The presence of subepithelial nodules on the glomerular basement membrane and deposits in the mesangium was demonstrated by electron microscopy. These findings suggest that this glomerulopathy induced by Forssman antibody may be a simple and reproducible model for the study of mesangial lesions.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1435-1463
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Catecholamine levels and weight of heart were studied in rats subjected to protein-calorie malnutrition and after a period of nutritional rehabilitation. Rats given a protein deficient diet (4% protein) for periods of 6 and 12 weeks showed a severe restriction of body weight gain. Nevertheless, even though the measured heart weight of deficient rats was significantly lower than the respective controls (16% protein), the deficient rats incurred “real” cardiac enlargement since the mean heart weight of the equal body weight controls was significantly different from that of the deficient animals. The mean heart weight of rats fed a high-protein diet for 6 weeks thereupon a 6-week period of protein deprivation was still less than that of controls, and the heart ratio was still greater than that of controls. However, the heart weight of rehabilitated rats was not significantly different from that of equal body weight controls. Serum protein and albumin levels in deficient rats were significantly decreased in comparison to rats fed a high-protein diet. While the serum protein levels of rehabilitated rats were lower than those of controls, the albumin levels were not different. The protein-calorie malnourished rats, which received a low-protein diet for 6 and 12 weeks, showed a significant increase in myocardium noradrenaline concentration. After a period of nutritional rehabilitation this change did not persist. These catecholaminergic alterations in heart may be responsible, at least in part, for the different cardiac abnormalities described as a result of protein-calorie dietary deficiency. It may also explain the “real” cardiac enlargement observed in deficient rats, according to the hypothesis that noradrenaline may be the ultimate myocardial hypertrophy hormone.
    Type of Medium: Electronic Resource
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