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Digitale Medien

Prospects for a small molecule able to induce somatic growth through the growth hormone receptor (1999)

Waters, M. J. ; Behncken, S. N. ; Conway-Campbell, B. ; [weitere]

Springer

International journal of peptide research and therapeutics 6 (1999), S. 353-357

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Details

ISSN: 1573-3904

Schlagwort(e): cytokine receptor ; dimerization ; growth hormone ; mutagenesis ; small mimetic

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie

Notizen: Summary This article reviews the prospects for a small-molecule agonist of the growth hormone receptor in the light of current successes in identifying small agonist molecules for other homomeric class 1 cytokine receptors. A variety of mutagenic analyses on both hormone and receptor, studies with monoclonal antibody agonists of the GH receptor, and the use of a constitutively dimerized GH receptor chimera which displays constitutive activity lead us to believe that such a development is possible. However, it is likely that a precise alignment of the lower cytokine receptor homology domains will be necessary in order to facilitate cross-activation of cytoplasmic Janus kinases bound to Box 1.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF02443432

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