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  • 1
    Electronic Resource
    Electronic Resource
    Component-specific effects of physostigmine on the cat visual evoked potential (1993)
    Springer
    Experimental brain research 95 (1993), S. 271-276 
    Details
    ISSN: 1432-1106
    Keywords: Acetylcholine ; Physostigmine ; Visualevoked potential ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Pattern visual evoked potentials (VEPs) were recorded from the pial surface of the cat primary visual cortex prior to and following the intravenous administration of physostigmine, an agent which blocks the enzyme responsible for the breakdown of synaptically released acetylcholine. The control VEP was composed of a small initial positive deflection (P1), a subsequent large negative wave (N1) and a second large positive wave (P2). Following physostigmine, the amplitude of P1-N1 was diminished whereas that of N1-P2 increased. These effects were long lasting and were blocked by prior treatment with scopolamine, a result consistent with mediation by a muscarinic cholinergic pathway. Waveform subtraction revealed that the physostigmine-sensitive component had a slow, negative polarity waveform while the physostigmine-insensitive component was also slow, but positive in polarity. The fundamental nature of these components remains to be assessed. Nevertheless, the results indicate that waveforms of different polarity combine algebraically to yield the conventional VEP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00229785
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Familial amyloidotic polyneuropathy: transthyretin (prealbumin) variants in kindreds of Italian origin (1988)
    Springer
    Human genetics 〈Berlin〉 80 (1988), S. 341-343 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary As part of an epidemiological study that aims to characterize chemically the mutation(s) in transthyretin (TTR) related to familial amyloidotic polyneuropathy (FAP) of different ethnic origins, studies were carried out on TTR from two FAP kindreds of Italian origin. Two different criteria were employed in the characterization of TTR from these kindreds: (1) immunoblotting of cyanogen bromide fragments for screening of TTR(Met30) and (2) isoelectric focusing. TTR(Met30) was not detected but other substitutions were demonstrated using isoelectric focusing techniques. One of the variants found is a basic TTR variant. The substitutions occurring in the variant TTRs of these two kindreds are not known and are presently under study.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00273648
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    PME of Unverricht-Lundborg type in the Mediterranean region: linkage and linkage disequilibrium confirm the assignment to the EPM1 locus (1994)
    Springer
    Human genetics 〈Berlin〉 93 (1994), S. 668-674 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Seven phenotypically homogeneous Mediterranean myoclonus families were studied using DNA markers from the genetically defined EPM1 region on chromosome 21. No recombinations between the disease phenotype and the markers studied were detected. Within the EPM1 region, the highest lod score value of 5.07 (at Θ = 0.00) was reached at locus PFKL. Significant allelic association (P = 0.02) between the disease mutation and PFKL was detected suggesting a founder effect in Mediterranean myoclonus. However, haplotype data using four marker loci residing within 300kb of each other and of EPM1 suggest the occurrence of more than one mutation. The data are compatible with Mediterranean myoclonus being caused by mutations in the EPM1 gene and strengthen the concept that a large subset of progressive myoclonus epilepsies conforms with Unverricht-Lundborg disease and that this subset is an etiologically homogeneous entity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00201568
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    The effects of physostigmine on the response characteristics of the cat visual evoked potential (1993)
    Springer
    Documenta ophthalmologica 84 (1993), S. 257-265 
    Details
    ISSN: 1573-2622
    Keywords: Acetylcholine ; Cat ; Physostigmine ; Scopolamine ; Visual cortex ; Visual evoked potential (VEP)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Steady—state pattern visual evoked potentials were recorded from the surface of the cat primary visual cortex before and after the intravenous administration of physostigmine, an agent that blocks the enzyme responsible for the breakdown of synaptically released acetylcholine. Under pentobarbital anesthesia, physostigmine increased the amplitude and changed the phase of the second response harmonic of the visual evoked potential, whereas the amplitude and phase of the fourth harmonic were not affected. These effects persisted for 15 to 45 minutes and were blocked by prior treatment with scopolamine or atropine. In addition, scopolamine or atropine administered 5 to 10 minutes after physostigmine returned the visual evoked potential to the baseline state. In comparison, when nitrous oxide was used, physostigmine caused a marked reduction in visual evoked potential amplitude, an effect that was reversed by subsequent atropine. These results indicate that the cholinergic system influences the visual evoked potential via a muscarinic pathway and that this influence is strongly affected by the anesthetic regimen used.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01203658
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    Paper (German National Licenses)
    Fulltext
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