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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK; Malden, USA : Munksgaard International Publishers
    Journal of cutaneous pathology 31 (2004), S. 0 
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background:  p63 is a p53 homolog and a marker expressed in replicating keratinocytes. Survivin is a recently characterized inhibitor of apoptosis protein that is abundantly expressed in most solid and hematologic malignancies. Telomerase reverse transcriptase (TERT) is the major determinant of human telomerase activity, and its expression is indicative of unlimited replication. We herein evaluated the expression profiles of p63, p53, survivin, and hTERT in usual skin cancers, including squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) and putative preneoplastic epidermal lesions, including actinic keratosis (AK), Bowen's diasease, and porokeratosis.Methods:  Immunohistochemistry using antibodies against p63, p53, survivin, and hTERT was performed. Semi-quantitative evaluation (–, +, 2+, 3+) was carried out.Results:  BCCs showed diffuse p63 expression and SCCs heterogeneous p63 expression with negativity in terminally differentiated squamous cells. All preneoplastic epidermal lesions showed p63 expression in all cell layers. p53 was found in seven of 10 cases of BCCs, all 10 cases of SCCs, and nine of 10 cases of Bowen's disease. AK and porokeratosis revealed focal to moderate p53 expression. Survivin was found in eight of 10 cases of SCCs and eight of 10 cases of Bowen's disease. Six of 10 cases of BCCs revealed weak survivin positivity. AK and porokeratosis showed survivin expression confined to the basal layer. hTERT expression was found in most cases of skin cancers and preneoplastic lesions.Conclusions:  p63 expression may be a marker of basal/progenitor cells and a diagnostic marker in skin tumors. p63 expression is not related to p53 expression in these tumors. This study points to a putative role of survivin and hTERT in the development of certain skin cancers. In addition, our data support the concept of porokeratosis being a premalignant condition.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-4803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract YBa2Cu3O7-δ (Y123)-Ag composite superconducting wires were fabricated by the plastic extrusion method which involves plastic paste making, die extrusion, binder burn-out and the firing process. The as-extruded Y123-Ag wires were so flexible that they can be easily fabricated into a desirable shape. The current-carrying properties of the wire are dependent on sample size, sintering temperature and silver content. The critical current density, Jc, of the Y123 wire with a large cross-section was lower than that of the wires with a small cross-section, probably due to the large self-induced magnetic field. Jc of the Y123-Ag wires increased with increasing sintering temperature but abruptly decreased above 910°C, which is close to the eutectic temperature of the Y–Ba–Cu–O system. A silver addition of 10–20 wt% slightly increased Jc of the Y123 (at 77 K and 0 T, it was 140 and 250 A cm-2 for the undoped Y123 wire and the Y123 wire with 20 wt% Ag addition, respectively), but further silver addition had a deleterious effect on Jc (180 A cm-2 for 30 wt% Ag addition). The small increment in Jc in the Y123 wire with 10–20 wt% Ag addition appears to be due to the enhanced densification and the associated microstructural variation. The decreased Jc of the Y123 wire with 30 wt% Ag addition is considered to be due to the formation of non-superconducting phase, Y2BaCuO5 (Y211), BaCuO2 and CuO phases via the decomposition of the Y123 phase.
    Type of Medium: Electronic Resource
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