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  • 1
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 225 (1970), S. 802-806 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The primary structure of porcine elastase has been determined by classical procedures of enzymatic digestion and chemical sequence analysis and shown to be closely related to those of chymotrypsins A and B and trypsin. Differences in side-chains offer an explanation of the differences in substrate ...
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 225 (1970), S. 806-811 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] X-ray diffraction data have been collected from four isomorphous crystalline derivatives of the proteolytic enzyme elastase, and a map of the three-dimensional electron density of the tosyl derivative has been calculated by Fourier synthesis of 2,750 independent terms. It shows clearly the ...
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 225 (1970), S. 811-816 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Amino-acid sequence studies and crystallographic evidence are used to construct an atomic model of elastase, which is compared with the structure of α-chymotrypsin. The single polypeptide chain of elastase is folded into two distinct and structurally similar halves displaying opposite ...
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 364 (1984), S. 520-520 
    ISSN: 1435-2451
    Keywords: Pathogenesis ; Hypovolemic, cardiogenic, septicemic shock ; Pathogenese ; Hypovolämischer, kardiogener, septischer Schock
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Voraussetzung für eine gezielte Behandlung des Schocks ist stets die Kenntnis der auslösenden Ursache und der daraus folgenden Reaktionen sowohl von seiten der Hämodynamik als auch im cellulären Bereich. Da die bekannte Schocksymptomatik eher Ausdruck der exzessiven Sympathicusaktivierung als der auslösenden Störung ist, liefern dieüblichen klinischen Zeichen oft keine ausreichende Grundlage für eine genaue Diagnose. Das Verständnis der Pathophysiologie, die zu der Schocksymptomatik führt, ist eine wesentliche Voraussetzung für die Diagnose und das Überleben des Patienten.
    Notes: Summary The treatment of shock is always based on consideration of the underlying disorder, the body's response, and the attending threats to cellular oxygenation and metabolism. Since the well-known shock syndrome is evidence of sympathetic discharge rather than of the disorder evoking it, obvious clinical features are often insufficient for precise diagnosis. An understanding of the pathophysiology leading to the shock syndrome is basic to diagnosis and to the patient's survival.
    Type of Medium: Electronic Resource
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