ISSN:
1573-4919
Keywords:
magnesium-deficiency
;
rats
;
tumor necrosis factor
;
thalidomide
;
interleukin-1
;
myocardial necrosis
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
Notes:
Abstract The effect of thalidomide on circulating cytokines and myocardial lesion formation was investigated in Mg-deficient rats. After two weeks on a Mg-deficient diet, rats show an increase in circulating levels of tumor necrosis factor-alpha and interleukin 1. Thalidomide (1 mg/day) caused a complete inhibition of the increase in circulating tumor necrosis factor-alpha levels, without having an effect on interleukin 1. However, a marked increase in cardiomyopathic lesion formation was observed in Mg-deficient animals treated with thalidomide; possible mechanisms for thalidomide's enhancement of myocardial injury are discussed. (Mol Cell Biochem129: 195–200, 1993)
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00926368
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