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Impaired Mitogen-Induced Interferon-γ Production in Rheumatoid Arthritis and Related Diseases (1988)

STOLZENBURG, T. ; BINZ, H. ; FONTANA, A. ; [et al.]

Oxford, UK : Blackwell Publishing Ltd

Scandinavian journal of immunology 27 (1988), S. 0

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ISSN: 1365-3083

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Peripheral blood lymphocytes from patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), progressive systemic sclerosis (PSS). Reiter's disease, osteoarthritis, and from healthy volunteers were investigated for interferon-γ (IFN-γ) production after mitogen activation. Phytohaemagglutinin stimulation revealed an impaired IFN-γ production in RA, SLE, and PSS but normal levels to Reiter's disease and osteoarthritis. In RA this deficiency was also seen after pokeweed mitogen. OKT3, and concanavalin A activation. No major differences were found in interleukin 2 (IL-2) production and cell proliferation. The IL-2 receptor expression was reduced on stimulated RA lymphocytes. The deficient IFN-γ production was compensated in RA by co stimulation of PHA or OKT3 with phorbol myristic acetate (PMA). In addition, the combination of the calcium ionophore A 23187 and PMA induced a strong IFN-γ secretion in all patient groups and in the controls.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1365-3083.1988.tb02324.x

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Elemental composition of aerosols in a small mixed land use watershed (1981)

Stolzenburg, T. R. ; Andren, A. W.

Springer

Water, air & soil pollution 15 (1981), S. 263-270

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ISSN: 1573-2932

Source: Springer Online Journal Archives 1860-2000

Topics: Energy, Environment Protection, Nuclear Power Engineering

Notes: Abstract The hypothesis of uniform elemental composition of continental aerosol is supported with data from samples taken in and around Milwaukee, Wisconsin. Simple dilution by regional atmospheric mixing processes is proposed to explain variations in absolute concentrations of the aerosol while the elemental composition remains essentially unchanged. There are, however, certain elements (Fe, Zn, and Mn) which show a marked enrichment in close proximity to industrial activities.