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  • 1
    Electronic Resource
    Electronic Resource
    Mechanism of the Toxic Effects of Hyperbaric Oxygen (1967)
    [s.l.] : Nature Publishing Group
    Nature 215 (1967), S. 1196-1196 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In the experiments described here, the reduction of NAD was studied by coupling it to a system which utilizes NADH, namely the synthesis of glutamate from a-oxoglutarate and ammonia4. Table 1 shows that oxygen at 3 atm. has no effect on the synthesis of glutamate, even after pre-incubation for 60 ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/2151196a0
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Plasma lipid peroxides and antioxidants in human septic shock (1991)
    Springer
    Intensive care medicine 17 (1991), S. 40-44 
    Details
    ISSN: 1432-1238
    Keywords: Septic shock ; Lipid peroxidation ; Alphatocopherol ; Selenium ; Oxygen free radicals ; Outcome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In order to assess if an oxidant/antioxidant imaalance is involved in human septic shock and its outcome, we measured plasma levels of the lipid peroxides malondialdehyde—as thiobarbituric acid reactive substance—conjugated dienes and fluorescent products, together with the antioxidants alpha-tocopherol, glutathione peroxidase activity and selenium in 12 patients with septic shock and compared them with values of normal controls. At first measurements, malondialdehyde (median 3.9 μmol/l; range 2–38.8) and fluorescent products (median 21.2%; range 9.4–134) were elevated (p〈0.05), alpha-tocopherol (median 15 μmol/l; range 7–25) and selenium (median 0.76 μg/ml; range 0.49–1.09) were depressed (p〈0.05). Conjugated dienes and glutathione peroxidase activity were in the normal range. In non-survivors (n=5) initial levels of malondialdehyde and fluorescent products (median 11 versus 3.1 μmol/l; 74 versus 135 respectively) were higher than in survivors (p〈0.05) and initial selenium levels were lower (median 0.58 versus 0.92 μg/l;p〈0.05). These results are consistent with the concept that an oxidant/antioxidant imbalance—as indicated by elevated plasma lipid peroxides and depressed antioxidants—is involved in human septic shock and a fatal outcome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01708408
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of single and repeated doses of oral omeprazole on gastric acid and pepsin secretion and fasting serum gastrin and serum pepsinogen I levels (1986)
    Springer
    Digestive diseases and sciences 31 (1986), S. 561-566 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of omeprazole on gastric acid and pepsin secretion and fasting serum gastrin and serum pepsinogen I levels was studied in 12 healthy volunteers. Omeprazole, 40 mg enteric-coated granules, or placebo was given once daily for nine days in a double-blind crossover study design. Twenty-four hours after a single dose of omeprazole, mean basal and mean pentagastrin-stimulated acid output decreased significantly. This effect was more pronounced after nine days of treatment. Basal pepsin output was significantly reduced only in those subjects with basal anacidity during omeprazole treatment. Stimulated pepsin output was slightly reduced after a single dose but unaltered after nine days of omeprazole. Fasting serum gastrin and serum pepsinogen I levels increased significantly during omeprazole treatment. It is concluded that omeprazole is a potent and selective inhibitor of gastric acid secretion, probably without a direct effect on pepsin secretion. However, in cases of basal anacidity during omeprazole administration, basal pepsin secretion is reduced. During omeprazole treatment, fasting serum levels of gastrin and pepsinogen I rise.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01318685
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    Paper (German National Licenses)
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