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  • 1
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Chromosome studies of peripheral blood lymphocytes were originally done on 4,342, 7-8-yr-old, children from the Collaborative Perinatal Study through the collaboration of cyto-genetic laboratories in five cities. The culture and harvest methods are described elsewhere5. Most of the data presented ...
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Thirteen phenotypically abnormal patients with previously identified de novo or familial, apparently balanced, chromosome rearrangenents were reexamined with highresolution techniques. No definite imbalance could be demonstrated in any of the cases. However, some breakpoints were reassigned to more specific sub-bands and others to totally different bands. The study confirmed translocation reciprocity in some cases in which metaphase banding techniques failed to allow such determination. In one patient an apparent extra dark band was observed which could be explained by limited uncoiling, intraband exchange or small band duplication. In two patients limited uncoiling was observed in one derivative chromosome. Tissue-limited mosaicism was discovered in cultured fibroblasts from one of the seven patients evaluated.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    International urogynecology journal 1 (1990), S. 12-18 
    ISSN: 1433-3023
    Keywords: Pathophysiology ; Stress incontinence ; Urinary incontinence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Urinary continence in the female is maintained as long as intraurethral pressure exceeds bladder pressure. The elements which maintain this condition at rest and during stress include: internal urethral sphincter, external urethral sphincter, anatomic support of the urethrovesical junction, and intact innervation. Urethral junction and presence of genuine stress incontinence may be best assessed by measurement of resting and stress urethral closure pressure profiles using multichannel urodynamic testing. The findings subsequent to urethral closure pressure profilometry influence the kind of therapy selected, including types of surgery, when this treatment option is chosen.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1433-3023
    Keywords: Genuine stress incontinence ; Low urethral closure pressure ; Suburethral sling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Forty-eight patients with genuine stress incontinence and low urethral closure pressure have undergone a suburethral sling procedure using polytetrafluoroethylene. Forty-five of the 48 patients have been followed up beyond 3 months, allowing assessment of postoperative complications. Ten patients required intermittent self-catheterization, 6 continuing beyond 3 months secondary to obstructed voiding or vesical dysfunction. Six slings were removed due to graft infection and/or vaginal mucosa erosion. All patients who were continent prior to removal remained so afterwards. Two slings were loosened secondary to obstructed voiding (1 patient experienced improved voiding, the other continued intermittent catheterization). Sixty-two per cent (28/45) of the patients followed, developed at least one documented urinary tract infection. Thirty-four of the 45 patients followed, underwent postoperative multichannel urodynamic testing. Ten patients (29%) demonstrated postoperative detrusor instability (5 were new onset, 5 were persistent). Six improved with medication and bladder retraining drills. Twenty-eight of the 34 patients tested (82.4%) were objectively cured of genuine stress incontinence. In spite of the complications noted, this suburethral sling procedure offers a high success rate and is a viable alternative in treating patients with genuine stress incontinence and low urethral closure pressure. Modifications in surgical technique have been made to reduce postoperative complications in the future.
    Type of Medium: Electronic Resource
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